Derivatives of (-)-7-methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2. 1]heptane are potential ligands for positron emission tomography imaging of extrathalamic nicotinic acetylcholine receptors

Journal of Medicinal Chemistry

Volumn 50, Issue 16, 2007, Pages 3814-3824

  Gao, Yongjun ^a   Horti, Andrew G ^a   Kuwabara, Hiroto ^a   Ravert, Hayden T ^a   Hilton, John ^a   Holt, Daniel P ^a   Kumar, Anil ^a   Alexander, Mohab ^a   Endres, Christopher J ^a   Wong, Dean F ^a   Dannals, Robert F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYL 2 [5 (PYRIDINYL)PYRIDIN 3 YL] 7 AZABICYCLO[2.2.1]HEPTANE DERIVATIVE; 7 METHYL 2 EXO [3' (2 FLUOROPYRIDIN 5 YL)] 5' PYRIDINYL] 7 AZABICYCLO[2.2.1]HEPTANE F 18; CARBON 11; FLUORINE 18; NICOTINIC RECEPTOR; NORBORNANE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BABOON; BINDING AFFINITY; CHIRALITY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RODENT; THALAMUS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; LIGANDS; MALE; MICE; PAPIO ANUBIS; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548090573     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070224t     Document Type: Article

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