Column-switching HPLC for the analysis of plasma in PET imaging studies

Nuclear Medicine and Biology

Volumn 27, Issue 6, 2000, Pages 627-630

  Hilton, John ^a   Yokoi, Fuji ^a   Dannals, Robert F ^a   Ravert, Hayden T ^a   Szabo, Zsolt ^a   Wong, Dean F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Column switch; HPLC; PET; Plasma

Indexed keywords

3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; CARBON 11; DRUG METABOLITE; RACLOPRIDE;

ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NONHUMAN; PLASMA PROTEIN BINDING; PLASMA VOLUME; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCAINE; DOPAMINE AGENTS; IMIDAZOLES; ISOQUINOLINES; LIGANDS; PYRIDINES; RACLOPRIDE; SENSITIVITY AND SPECIFICITY; SOLVENTS; TETRABENAZINE; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED; UREA;

EID: 0033753706     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00125-6     Document Type: Article

References (3)

1. The disposition of formaldehyde and formate arising from drug N-demethylations dependent on cytochrome P-450 in hepatocytes and in perfused rat liver
2. Automated determination of drugs in blood samples after enzymatic hydrolysis using precolumn switching and post-column reaction detection
3. Evaluation of liquid chromatographic behavior of restricted-access media precolumns in the course of direct injection of large volumes of plasma samples in column-switching systems