Smoking upregulates α4β2* nicotinic acetylcholine receptors in the human brain

Neuroscience Letters

Volumn 430, Issue 1, 2008, Pages 34-37

  Wüllner, Ullrich ^a   Gündisch, Daniela ^a   Herzog, Hans ^b   Minnerop, Martina ^a,b   Joe, Alexis ^c   Warnecke, Marc ^a   Jessen, Frank ^a   Schütz, Christian ^a   Reinhardt, Michael ^c   Eschner, Wolfgang ^d   Klockgether, Thomas ^a   Schmaljohann, Joern ^a,c  

^a UNIVERSITY OF BONN   (Germany)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c Department of Nuclear Medicine ^*  (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

2 18F F A 85380; Nicotinic acetylcholine receptors; Positron emission tomography; Smoking

Indexed keywords

2[F 18]FLUORO 3 (2 AZETIDINYLMETHOXY)PYRIDINE; NICOTINE; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4BETA2; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; NICOTINIC RECEPTOR ALPHA4BETA2;

ADULT; ARTICLE; BRAIN MAPPING; BRAIN STEM; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; MALE; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; SMOKING; TOBACCO DEPENDENCE; UPREGULATION; ADDICTION; BRAIN; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY;

BEHAVIOR, ADDICTIVE; BRAIN; HUMANS; MALE; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, NICOTINIC; SMOKING; UP-REGULATION;

EID: 37549031240     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.10.011     Document Type: Article

References (23)

1. 3H]nicotine binding site in human brain. J. Neurochem. 50 (1988) 1243-1247
2. Brody A.L., Mandelkern M.A., London E.D., Olmstead R.E., Farahi J., Scheibal D., Jou J., Allen V., Tiongson E., Chefer S.I., Koren A.O., and Mukhin A.G. Cigarette smoking saturates brain alpha4 beta2 nicotinic acetylcholine receptors. Arch. Gen. Psychiatry 63 (2006) 907-915
3. Buisson B., and Bertrand D. Chronic exposure to nicotine upregulates the human a4b2 nicotinic acetylcholine receptor function. J. Neurosci. 21 (2001) 1819-1829
4. 18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter. Synapse 53 (2004) 184-189
5. 18F-fluoro-A-85380 and PET. J. Nucl. Med. 46 (2005) 240-247
6. Gotti C., Zoli M., and Clementi F. Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Trends Pharmacol. Sci. 27 (2006) 482-491
7. 18F]F-A85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. FASEB J. 17 (2003) 1331-1343
8. Kinomura S., Larsson J., Gulyas B., and Roland P.E. Activation by attention of the human reticular formation and thalamic intralaminar nuclei. Science 271 (1996) 512-515
9. Kumari V., Gray J.A., Ffytche D.H., Mitterschiffthaler M.T., Das M., Zachariah E., Vythelingum G.N., Williams S.C., Simmons A., and Sharma T. Cognitive effects of nicotine in humans: an fMRI study. Neuroimage 19 (2003) 1002-1013
10. Lee M., Martin-Ruiz C., Graham A., Court J., Jaros E., Perry R., Iversen P., Bauman M., and Perry E. Nicotinic receptor abnormalities in the cerebellar cortex in autism. Brain 125 (2002) 1483-1495
11. Levin E.D. Nicotinic receptor subtypes and cognitive function. J. Neurobiol. 53 (2002) 633-640
12. Marks M.J., Burch J.B., and Collins A.C. Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. J. Pharmacol. Exp. Ther. 226 (1983) 817-825
13. Martin-Ruiz C.M., Court J.A., Molnar E., Lee M., Gotti C., Mamalaki A., Tsouloufis T., Tzartos S., Ballard C., Perry R.H., and Perry E.K. Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease. J. Neurochem. 73 (1999) 1635-1640
14. Nashmi R., Dickinson M.E., McKinney S., Jareb M., Labarca C., Fraser S.E., and Lester H.A. Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J. Neurosci. 23 (2003) 11554-11567
15. Paterson D., and Nordberg A. Neuronal nicotinic receptors in the human brain. Prog. Neurobiol. 61 (2000) 75-111
16. 18F]F-A-85390, a novel PET ligand for a4b2 nicotinic receptors. In: Society for Neuroscience 30th Annual Meeting, vol. 26, 2000, 627,235.16 (Abstract).
17. Perry D.C., Davila-Garcia M.I., Stockmeier C.A., and Kellar K.J. Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J. Pharmacol. Exp. Ther. 289 (1999) 1545-1552
18. Schmahmann J.D. Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J. Neuropsychiatry Clin. Neurosci. 16 (2004) 367-378
19. 18F]F-A85380: optimized synthesis and in vitro evaluation in Alzheimer's disease. Appl. Rad. Iso. 61 (2004) 1235-1240
20. Tapper A.R., McKinney S.L., Nashmi R., Schwarz J., Deshpande P., Labarca C., Whiteaker P., Marks M.J., Collins A.C., and Lester H.A. Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science 306 (2004) 1029-1032
21. Todd R.D., Lobos E.A., Sun W.L., and Neuman R.J. Mutational analysis of the nicotinic acetylcholine receptor alpha 4 subunit gene in attention deficit/hyperactivity disorder: evidence for association of an intronic polymorphism with attention problems. Mol. Psychiatry 8 (2003) 103-108
22. Vallejo Y.F., Buisson B., Bertrand D., and Green W.N. Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism. J. Neurosci. 25 (2005) 5563-5572
23. Wittchen H., Zaudig M., and Fydrich T. Strukturiertes Klinisches Interview für DSMIV (SKID) (1997), Hogrefe, Göttingen