New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7759-7769

  León, Rafael ^a,b   Ríos, Cristóbal de los ^a,b   Marco Contelles, José ^a   Huertas, Oscar ^d   Barril, Xavier ^e   Javier Luque, F ^d   López, Manuela G ^b   García, Antonio G ^b,c   Villarroya, Mercedes ^b  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

AChE; BuChE; Inhibition mechanism; Kinetic analysis; Molecular modeling; Neuroprotection; Tacrine dihydropyridine hybrids; Voltage dependent calcium channels

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; 11 AMINO 12 (4' FLUOROPHENYL) 3,3 DIMETHYL 3,4,5,7,8,9,10,12 OCTAHYDRODIBENZO[B,G][1,8]NAPHTHYRIDINE 1 (2H) ONE; 11 AMINO 12 (4' METHOXYPHENYL) 3,3 DIMETHYL 3,4,5,7,8,9,10,12 OCTAHYDRODIBENZO[B,G][1,8]NAPHTHYRIDINE 1 (2H) ONE; 11 AMINO 3,3 DIMETHYL 12 (4' METHYLPHENYL) 3,4,5,7,8,9,10,12 OCTAHYDRODIBENZO[B,G][1,8]NAPHTHYRIDINE 1 (2H) ONE; 11 AMINO 3,3 DIMETHYL 3,4,5,7,8,9,10,12 OCTAHYDRO 12 (4' PYRIDYL) DIBENZO[B,G][1,8]NAPHTHYRIDINE 1 (2H) ONE; 11 AMINO 3,3 DIMETHYL 3,4,5,7,8,9,10,12 OCTAHYDRO 12 PHENYL DIBENZO[B,G][1,8]NAPHTHYRIDINE 1 (2H) ONE; ACETYLCHOLINESTERASE; CALCIUM; CALCIUM CHANNEL L TYPE; POTASSIUM; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUROPROTECTION; PROTON NUCLEAR MAGNETIC RESONANCE;

ACETYLCHOLINESTERASE; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL LINE, TUMOR; CELL SURVIVAL; CHOLINESTERASE INHIBITORS; DIHYDROPYRIDINES; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; NEUROPROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, INFRARED; TACRINE;

EID: 49449083916     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.005     Document Type: Article

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