Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death

European Journal of Medicinal Chemistry

Volumn 43, Issue 3, 2008, Pages 668-674

  León, Rafael ^a,b   de los Ríos, Cristóbal ^a,b   Marco Contelles, José ^a   López, Manuela G ^b   García, Antonio G ^b,c   Villarroya, Mercedes ^b  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

Author keywords

2 Amino 4 aryl 7,7 dimethyl 5 oxo 1,4,5,6,7,8 hexahydro 3 quinolinenitriles; 6 Amino 1,4 dihydropyridines; Ethyl 6 amino 4 aryl 5 cyano 1,4 dihydro 2 methyl 3 pyridinecarboxylic acids; Neuroprotection; Voltage dependent calcium channels

Indexed keywords

2 AMINO 4 ARYL 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDRO 3 QUINOLINECARBONITRILE DERIVATIVE; 2 AMINO 4 ARYL 7,7 DIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDRO 3 QUINOLINENITRILE DERIVATIVE; 6 AMINO 1,4 DIHYDROPYRIDINE DERIVATIVE; CALCIUM; CALCIUM CHANNEL; DIHYDROPYRIDINE DERIVATIVE; ETHYL 6 AMINO 4 ARYL 5 CYANO 1,4 DIHYDRO 2 METHYL 3 PYRIDINE CARBOXYLIC ACID DERIVATIVE; HYDROGEN PEROXIDE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN NERVE CELL; CALCIUM METABOLISM; CELL DEATH; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROPROTECTION;

EID: 40049111197     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.001     Document Type: Article

References (24)

1. W.G. Mayler Calcium Antagonists 1989 Academic Press London
2. F. Bossert W. Vater Med. Res. Rev. 9 1989 291 324
3. K.M.M. Murphy R.J. Gould B.L. Largent S.H. Snyder Proc. Natl. Acad. Sci. U.S.A. 80 1983 860 864
4. D.R. Ferry H. Glossmann Naunyn.-Schmiedeberg's Arch. Pharmacol. 321 1982 80 83
5. T.M. Itil S.T. Michael F. Hoffmeister A. Kunitz E. Eralp Curr. Ther. Res. 35 1984 405 422
6. S. Goldmann J. Stoltefuss Angew. Chem., Int. Ed. Engl. 30 1991 1559 1578
7. M. Schramm G. Thomas R. Towart G. Franckowiak Nature 303 1983 535 537
8. R. Budriesi A. Bisi P. Ioan A. Rampa S. Gobbi F. Belluti L. Piazzi P. Valenti A. Chiarini Bioorg. Med. Chem. 13 2005 3423 3430
9. A. Guzmán M. Romero A. Maddox J. Muchowski J. Org. Chem. 55 1990 5793 5797
10. J.-T. Nguyen C.A. Velázquez E.E. Knaus Bioorg. Med. Chem. 13 2005 1725 1738
11. H.-G. Heine, B. Junge, R. Schohe-Loop, H. Sommermeyer, T. Glaser, R. Wittka, J.-M.V. de Vry, EP 075820, 1996.
12. R. Troschütz Arch. Pharm. 322 1989 285 290
13. K. Urbahns, S. Goldmann, H.-G. Heine, B. Junge, R. Schohe-Loop, H. Sommermeyer, T. Glaser, R. Wittka, J.-M.V. de Vry, DE 4,430,095, 1996.
14. M. Suárez Y. Verdecia E. Ochoa N. Martín R. Martínez M. Quinteiro C. Seoane J.L. Soto H. Novoa N. Blaton O.M. Peeters C. De Ranter J. Heterocycl. Chem. 37 2000 735 742
15. K. Yamagata S. Ichinose M. Tagami Hypertens. Res. 27 2004 271 282
16. T. Yagami K. Ueda T. Sakaeda N. Itoh G. Sakaguchi N. Okamura Y. Hori M. Fujimoto Biochem. Pharmacol. 67 2004 1153 1165
17. M. Sobrado M.G. López F. Carceller A.G. García J.M. Roda Neuroscience 118 2003 107 113
18. J. Marco-Contelles R. León C. de los Ríos A. Giugletta J. Terencio M.G. López A.G. García M. Villarroya J. Med. Chem. 49 2006 7607 7610
19. A. Dondoni A. Massi E. Minghini V. Bertolasi Helv. Chim. Acta 85 2002 3331 3347
20. R.J. Balzly J. Am. Chem. Soc. 74 1952 4586 4589
21. C.S. Marvel J.K. Stille J. Org. Chem. 22 1957 1451 1457
22. S. Tu J. Zhang X. Zhu Y. Zhang Q. Wang J. Xu B. Jiang R. Jia J. Zhang F. Shi J. Heterocycl. Chem. 43 2006 985 988
23. I. Kompis P. Schonholzer Helv. Chim. Acta 60 1977 618 628
24. F. Zymalkowski H. Rimek Arch. Pharm. 294 1961 759 765