Juliflorine: A potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for Alzheimer's disease therapy

Biochemical and Biophysical Research Communications

Volumn 332, Issue 4, 2005, Pages 1171-1179

  Choudhary, M Iqbal ^a   Nawaz, Sarfraz Ahmad ^a   Zaheer Ul Haq, ^a   Azim, M Kamran ^a   Ghayur, M Nabeel ^b   Lodhi, M Arif ^a   Jalil, Saima ^a   Khalid, Asaad ^a   Ahmed, Amir ^a   Rode, Bernd M ^c   Atta Ur Rahman, ^a   Gilani, Anwar Ul Hassan ^b   Ahmad, Viqar Uddin ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b AGA KHAN UNIVERSITY   (Pakistan)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Calcium channel blocker; Enzyme inhibition studies; Juliflorine; Molecular docking

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; HYDROGEN; JULIFLORINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CHOLINESTERASE INHIBITION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; IC 50; MOLECULAR MODEL; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPASMOLYSIS; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ALZHEIMER DISEASE; ANIMALS; BINDING SITES; CALCIUM; CALCIUM CHANNELS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUTROPHILS; PROTEIN BINDING; PROTEIN CONFORMATION; TORPEDO; TYROSINE;

ORYCTOLAGUS CUNICULUS; PROSOPIS JULIFLORA;

EID: 20444415656     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.068     Document Type: Article

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