Lambda light chain revision in the human intestinal IgA response

Journal of Immunology

Volumn 181, Issue 2, 2008, Pages 1264-1271

  Su, Wen ^a   Gordon, John N ^b   Barone, Francesca ^a   Boursier, Laurent ^a   Turnbull, Wayne ^a   Mendis, Surangi ^a   Dunn Walters, Deborah K ^a   Spencer, Jo ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN HEAVY CHAIN; SIGNAL PEPTIDE; DNA BINDING PROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; NUCLEAR PROTEIN; RAG2 PROTEIN, HUMAN;

ANTIBODY RESPONSE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; GENE; GENE INACTIVATION; GENE LOCUS; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CELL; LAMBDA LIGHT CHAIN; LIGHT CHAIN; NUCLEOTIDE SEQUENCE; PLASMA CELL; PRIORITY JOURNAL; PROTEIN STRUCTURE; UNINDEXED SEQUENCE; ANTIBODY SPECIFICITY; B LYMPHOCYTE; CYTOLOGY; GENE REARRANGEMENT; GENETICS; IMMUNOGLOBULIN GENE; IMMUNOLOGY; INTESTINE MUCOSA; METABOLISM; SOMATIC HYPERMUTATION;

ANTIBODY DIVERSITY; ANTIBODY SPECIFICITY; B-LYMPHOCYTES; DNA-BINDING PROTEINS; GENE REARRANGEMENT, B-LYMPHOCYTE, LIGHT CHAIN; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; INTESTINAL MUCOSA; NUCLEAR PROTEINS; PLASMA CELLS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 49049109922     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.2.1264     Document Type: Article

References (39)

1. Conley, M. E., and D. L. Delacroix. 1987. Intravascular and mucosal immunoglobulin A: two separate but related systems of immune defense? Ann. Intern. Med. 106: 892-899.
2. Brandtzaeg, P., I. N. Farstad, F. E. Johansen, H. C. Morton, I. N. Norderhaug, and T. Yamanaka. 1999. The B-cell system of human mucosae and exocrine glands. Immunol. Rev. 171: 45-87. (Pubitemid 29504711)
3. Fagarasan, S., M. Muramatsu, K. Suzuki, H. Nagaoka, H. Hiai, and T. Honjo. 2002. Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298: 1424-1427. (Pubitemid 35346143)
4. Holtmeier, W., A. Hennemann, and W. F. Caspary. 2000. IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated. Gastroenterology 119: 1253-1266.
5. Boursier, L., J. N. Gordon, S. Thiagamoorthy, J. D. Edgeworth, and J. Spencer. 2005. Human intestinal IgA response is generated in the organized gut-associated lymphoid tissue but not in the lamina propria: human intestinal IgA response is generated in the organized gut-associated lymphoid tissue but not in the lamina propria. Gastroenterology 128: 1879-1889.
6. Brauninger, A., T. Goossens, K. Rajewsky, and R. Kuppers. 2001. Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human. Eur. J. Immunol. 31: 3631-3637. (Pubitemid 34030976)
7. Klein, F., N. Feldhahn, J. L. Mooster, M. Sprangers, W. K. Hofmann, P. Wernet, M. Wartenberg, and M. Muschen. 2005. Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement. J. Immunol. 174: 367-375. (Pubitemid 40007424)
8. Goossens, T., A. Brauninger, U. Klein, R. Kuppers, and K. Rajewsky. 2001. Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation. Eur. J. Immunol. 31: 3638-3648. (Pubitemid 34030977)
9. Dunn-Walters, D. K., M. Hackett, L. Boursier, P. J. Ciclitira, P. Morgan, S. J. Challacombe, and J. Spencer. 2000. Characteristics of human IgA and IgM genes used by plasma cells in the salivary gland resemble those used in duodenum but not those used in the spleen. J. Immunol. 164: 1595-1601.
10. Su, W., L. Boursier, A. Padala, J. D. Sanderson, and J. Spencer. 2004. Biases in Ig lambda light chain rearrangements in human intestinal plasma cells. J. Immunol. 172: 2360-2366. (Pubitemid 38182384)
11. Banerjee, M., R. Mehr, A. Belelovsky, J. Spencer, and D. K. Dunn-Walters. 2002. Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees. Eur. J. Immunol. 32: 1947-1957. (Pubitemid 34814551)
12. González-Fernández, A., D. Gilmore, and C. Milstein. 1994. Age-related decrease in the proportion of germinal center B cells from mouse Peyer's patches is accompanied by an accumulation of somatic mutations in their immunoglobulin genes. Eur. J. Immunol. 24: 2918-2921. (Pubitemid 2150075)
13. Brandtzaeg, P., E. S. Baekkevold, and H. C. Morton. 2001. From B to A the mucosal way. Nat. Immunol. 2: 1093-1094.
14. Casola, S., K. L. Otipoby, M. Alimzhanov, S. Humme, N., Uyttersprot, J. L., Kutok, Carroll, M. C., and K. Rajewsky. 2004. B cell receptor signal strength determines B cell fate. Nat. Immunol. 5: 317-327. (Pubitemid 38332129)
15. Girschick, H. J., A. C. Grammer, T. Nanki, E. Vazquez, and P. E. Lipsky. 2002. Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus. Arthritis Rheum. 46: 1255-1263. (Pubitemid 34525833)
16. Rosenquist, R., F. Menestrina, M. Lestani, R. Kuppers, M. L. Hansmann, and A. Brauninger. 2004. Indications for peripheral light-chain revision and somatic hypermutation without a functional B-cell receptor in precursors of a composite diffuse large B-cell and Hodgkin's lymphoma. Lab. Invest. 84: 253-262. (Pubitemid 41656507)
17. Giachino, C., E. Padovan, and A. Lanzavecchia. 1998. Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes. Eur. J. Immunol. 28: 3506-3513. (Pubitemid 28510761)
18. Meru, N., A. Jung, I. Baumann, and G. Niedobitek. 2002. Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils. Blood 99: 531-537. (Pubitemid 34533089)
19. Yu, W., H. Nagaoka, M. Jankovic, Z. Misulovin, H. Suh, A. Rolink, F. Melchers, E. Meffre, and M. C. Nussenzweig. 1999. Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization. Nature 400: 682-687. (Pubitemid 129516184)
20. Clarke, S. H., L. M. Staudt, J. Kavaler, D. Schwartz, W. U. Gerhard, and M.G. Weigert. 1990. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. J. Immunol. 144: 2795-2801.
21. Kavaler, J., A. J. Caton, L. M. Staudt, and W. A. Gerhard. 1991. B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory response. Eur. J. Immunol. 21: 2687-2695.
22. Shannon, M., and R. Mehr. 1999. Reconciling repertoire shift with affinity maturation: the role of deleterious mutations. J. Immunol. 162: 3950-3956. (Pubitemid 29314774)
23. Kleinstein, S. H., Y. Louzoun, and M. J. Shlomchik. 2003. Estimating hypermutation rates from clonal tree data. J. Immunol. 171: 4639-4649. (Pubitemid 37310580)
24. Reynaud, C. A., C. Garcia, W. R. Hein, and J. C. Weill. 1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80: 115-125.
25. Mehr, R., H. Edelman, D. Sehgal, and R. Mage. 2004. Analysis of mutational lineage trees from sites of primary and secondary Ig gene diversification in rabbits and chickens. J. Immunol. 172: 4790-4796. (Pubitemid 38456400)
26. Traggiai, E., S. Becker, K. Subbarao, L. Kolesnikova, Y. Uematsu, M. R. Gismondo, B. R. Murphy, R. Rappuoli, and A. Lanzavecchia. 2004. An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat. Med. 10: 871-875. (Pubitemid 39070862)
27. + B cells. J. Clin. Invest. 99: 1614-6427.
28. Farner, N. L., T. Dorner, and P. E. Lipsky. 1999. Molecular mechanisms and selection influence the generation of the human V λ J λ repertoire. J. Immunol. 162: 2137-2145.
29. Chothia, C., A. M. Lesk, E. Gherardi, I. M. Tomlinson, G. Walter, J. D. Marks, M. B. Llewelyn, and G. Winter. 1992. Structural repertoire of the human VH segments. J. Mol. Biol. 227: 799-817.
30. Coker, H. A., S. R. Durham, and H. J. Gould. 2003. Local somatic hypermutation and class switch recombination in the nasal mucosa of allergic rhinitis patients. J. Immunol. 171: 5602-5610.
31. Casellas, R., Q. Zhang, N. Y. Zheng, M. D. Mathias, K. Smith, and P. C. Wilson. 2007. Igκ allelic inclusion is a consequence of receptor editing. J. Exp. Med. 204: 153-160. (Pubitemid 46148765)
32. Diss, T. C., H. Peng, A. C. Wotherspoon, P. G. Isaacson, and L. Pan. 1993. Detection of monoclonality in low-grade B-cell lymphomas using the polymerase chain reaction is dependent on primer selection and lymphoma type. J. Pathol. 169: 291-295.
33. Nadel, B., A. Tang, and A. J. Feeney. 1998. V(H) replacement is unlikely to contribute significantly to receptor editing due to an ineffectual embedded recombination signal sequence. Mol. Immunol. 35: 227-232. (Pubitemid 28374930)
34. Zhang, Z., X. Wu, B. H. Limbaugh, S. L. Bridges, Jr. 2001. Expression of recombination- activating genes and terminal deoxynucleotidyl transferase and secondary rearrangement of immunoglobulin κ light chains in rheumatoid arthritis synovial tissue. Arthritis Rheum. 44: 2275-2284.
35. Allen, C. D., T. Okada, H. L. Tang, and J. G. Cyster. Imaging of germinal center selection events during affinity maturation. Science 315: 528-531.
36. Suzuki, K., Y. Akahori, Y. Asano, Y. Kurosawa, and K. Shiraki. 2007. Isolation of therapeutic human monoclonal antibodies for varicella-zoster virus and the effect of light chains on the neutralizing activity. J. Med. Virol. 79: 852-862. (Pubitemid 46709382)
37. de Wildt, R. M., R. M. Hoet, W. J. van Venrooij, I. M. Tomlinson, and G. Winter. 1999. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J. Mol. Biol. 285: 895-901.
38. Girschick, H. J., A. C. Grammer, T. Nanki, M. Mayo, and P. E. Lipsky. 2001. RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. J. Immunol. 166: 377-386.
39. Hillion, S., M. Dueymes, P. Youinou, and C. Jamin. 2007. IL-6 contributes to the expression of RAGs in human mature B cells. J. Immunol. 179: 6790-6798.