Biases in Ig λ Light Chain Rearrangements in Human Intestinal Plasma Cells

Journal of Immunology

Volumn 172, Issue 4, 2004, Pages 2360-2366

  Su, Wen ^a   Boursier, Laurent ^a   Padala, Archana ^a   Sanderson, Jeremy D ^b   Spencer, Jo ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN LAMBDA CHAIN;

AGED; ARTICLE; B LYMPHOCYTE; CASE REPORT; CONTROLLED STUDY; FEMALE; GENE REARRANGEMENT; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; LYMPH FOLLICLE; LYMPHOID TISSUE; MALE; NUCLEOTIDE SEQUENCE; PEYER PATCH; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; UNINDEXED SEQUENCE;

EID: 0842321783     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.4.2360     Document Type: Article

References (34)

1. Oettinger, M. A., D. G. Schatz, C. Gorka, and D. Baltimore. 1990. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517.
2. Willefford, D. M., W. Swat, and F. W. Alt. 1996. Developmental regulation of V(D)J recombination and lymphocyte differentiation. Curr. Opin. Genet. Dev. 6:603.
3. Melchers, F., H. Karasuyama, D. Haasner, S. Bauer, A. Kudo, N. Sakaguchi, B. Jameson, and A. Rolink. 1993. The surrogate light chain in B-cell development. Immunol. Today 14:60.
4. Siminovitch, K. A., A. Bakhshi, P. Goldman, and S. J. Korsmeyer. 1985. A uniform deleting element mediates the loss of κ genes in human B cells. Nature 316:260.
5. Oberdoerffer, P., T. I. Novobrantseva, and K. Rajewsky. 2003. Expression of a targeted λ1 light chain gene is developmentally regulated and independent of Ig κ rearrangements. J. Exp. Med. 197:1165.
6. Casellas, R., M. Jankovic, G. Meyer, A. Gazumyan, Y. Luo, R. Roeder, and M. Nussenzweig. 2002. OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin κ genes. Cell 110:575.
7. Hieter, P. A., S. J. Korsmeyer, T. A. Waldmann, and P. Leder. 1981. Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells. Nature 290:368.
8. van der Burg, M., B. H. Barendregt, T. Szczepanski, E. R. van Wering, A. W. Langerak, and J. J. van Dongen. 2002. Immunoglobulin light chain gene rearrangements display hierarchy in absence of selection for functionality in precursor-B-ALL. Leukemia 16:1448.
9. Brauninger, A., T. Goossens, K. Rajewsky, and R. Kuppers. 2001. Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human. Eur. J. Immunol. 31:3631.
10. McCormack, W. T., L. W. Tjoelker, C. F. Barth, L. M. Carlson, B. Petryniak, E. H. Humphries, and C. B. Thompson. 1989. Selection for B cells with productive IgL gene rearrangements occurs in the bursa of Fabricius during chicken embryonic development. Genes Dev. 3:838.
11. Sinkora, M., J. Sun, J. Sinkorova, R. K. Christenson, S. P. Ford, and J. E. Butler. 2003. Antibody repertoire development in fetal and neonatal piglets. VI. B cell lymphogenesis occurs at multiple sites with differences in the frequency of inframe rearrangements. J. Immunol. 170:1781.
12. Famer, N. L., T. Dorner, and P. E. Lipsky. 1999. Molecular mechanisms and selection influence the generation of the human VλJλ repertoire. J. Immunol. 162:2137.
13. Kuppers, R., and R. Dalla-Favera. 2001. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20:5580.
14. Goossens, T., U. Klein, and R. Kuppers. 1998. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc. Natl. Acad. Sci. USA 95:2463.
15. zur Stadt, U., G. Hoser, A. Reiter, K. Welte, and K. W. Sykora. 1997. Application of long PCR to detect t(8;14)(q24;q32) translocations in childhood Burkitt's lymphoma and B-ALL. Ann. Oncol. 8(Suppl.)1:31.
16. Boursier, L., D. K. Dunn-Walters, and J. Spencer. 2000. Sequence analysis of light chain genes from human plasma cells demonstrates that λ genes are almost all in-frame and highly mutated and most κ genes are highly mutated when in-frame and minimally mutated when out-of-frame. Eur. J. Immunol. 30:2908.
17. Dunn-Walters, D. K., P. G. Isaacson, and J. Spencer. 1996. Sequence analysis of rearranged IgVH genes from microdissected human Peyer's patch marginal zone B cells. Immunology 88:618.
18. Dunn-Walters, D. K., P. G. Isaacson, and J. Spencer. 1997. Sequence analysis of human IgVH genes indicates that ileal plasma cells are derived from Peyer's patches. Eur. J. Immunol. 27:463.
19. Kroese, F. G., E. C. Butcher, A. M. Stall, P. A. Lalor, S. Adams, and L. A. Herzenberg. 1989. Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity. Int. Immunol. 1:75.
20. Boursier, L., I. N. Farstad, J. R. Mellembakken, P. Brandtzaeg, and J. Spencer. 2002. IgVH gene analysis suggests that peritoneal B cells do not contribute to the gut immune system in man. Eur. J. Immunol. 32:2427.
21. Dunn-Walters, D. K., P. G. Isaacson, and J. Spencer. 1995. Analysis of mutations in IgVH genes of microdissected marginal zone B cells suggests that the marginal zone of human spleen is a reservoir of memory B cells. J. Exp. Med. 182:559.
22. Brauninger, A., R. Kuppers, T. Spieker, R. Siebert, J. G. Strickler, B. Schlegelberger, K. Rajewsky, and M. L. Hansmann. 1999. Molecular analysis of single B cells from T-cell-rich B-cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells. Blood 93:2679.
23. Ignatovich, O., I. M. Tomlinson, P. T. Jones, and G. Winter. 1997. The creation of diversity the human immunoglobulin Vλ repertoire. J. Mol. Biol. 268:69.
24. Gay, D., T. Saunders, S. Camper, and M. Weigert. 1993. Receptor editing: an approach by autoreactive B cells to escape tolerance. J Exp. Med. 177:999.
25. Tiegs, S. L., D. M. Russell, and D. Nemazee. 1993. Receptor editing in self-reactive bone marrow B cells. J Exp. Med. 177:1009.
26. de Wildt, R. M., R. M. Hoet, W. J. van Venrooij, I. M. Tomlinson, and G. Winter. 1999. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. J. Mol. Biol. 285:895.
27. Hikida, M., and H. Ohmori. 1998. Rearrangement of λ light chain genes in mature B cells in vitro and in vivo: function of re-expressed recombination-activating gene (RAG) products. J. Exp. Med. 187:795.
28. Giachino, C., E. Padovan, and A. Lanzavecchia. 1998. Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes. Eur. J. Immunol. 28:3506.
29. Girschick, H. J., A. C. Grammer, T. Nanki, M. Mayo, and P. E. Lipsky. 2001. RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. J Immunol. 166:377.
30. Lee, J., N. L. Monson, and P. E. Lipsky. 2000. The VλJλ repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing. J. Immunol. 165:6322.
31. Goossens, T., A. Brauninger, U. Klein, R. Kuppers, and K. Rajewsky. 2001. Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation. Eur. J. Immunol. 31:3638.
32. Meffre, E., N. Catalan, F. Seltz, A. Fischer, M. C. Nussenzweig, and A. Durandy. 2001. Somatic hypermutation shapes the antibody repertoire of memory B cells in humans. J. Exp. Med. 194:375.
33. Tachibana, H., H. Haruta, and K. Yamada. 1999. Light chain shifting: identification of a human plasma cell line actively undergoing light chain replacement. Blood 93:198.
34. Liu, Y. J., J. Zhang, P. J. Lane, E. Y. Chan, and I. C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951.