-
1
-
-
0034268780
-
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
-
Muramatsu, M., K. Kinoshita, S. Fagarasan, S. Yamada, Y. Shinkai, and T. Honjo. 2000. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102: 553-563.
-
(2000)
Cell
, vol.102
, pp. 553-563
-
-
Muramatsu, M.1
Kinoshita, K.2
Fagarasan, S.3
Yamada, S.4
Shinkai, Y.5
Honjo, T.6
-
2
-
-
0023431206
-
Diversity and the genesis of high affinity antibodies
-
Milstein, C. 1987. Diversity and the genesis of high affinity antibodies. Biochem. Soc. Trans. 15: 779-787.
-
(1987)
Biochem. Soc. Trans.
, vol.15
, pp. 779-787
-
-
Milstein, C.1
-
3
-
-
0034264851
-
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2)
-
Revy, P., T. Muto, Y. Levy, F. Geissmann, A. Plebani, O. Sanal, N. Catalan, M. Forveille, R. Dufourcq-Labelouse, A. Gennery, et al. 2000. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2). Cell 102: 565-575.
-
(2000)
Cell
, vol.102
, pp. 565-575
-
-
Revy, P.1
Muto, T.2
Levy, Y.3
Geissmann, F.4
Plebani, A.5
Sanal, O.6
Catalan, N.7
Forveille, M.8
Dufourcq-Labelouse, R.9
Gennery, A.10
-
4
-
-
0035817384
-
Somatic hypermutation shapes the antibody repertoire of memory B cells in humans
-
DOI 10.1084/jem.194.3.375
-
Meffre, E., N. Catalan, F. Seltz, A. Fischer, M. C. Nussenzweig, and A. Durandy. 2001. Somatic hypermutation shapes the antibody repertoire of memory B cells in humans. J. Exp. Med. 194: 375-378. (Pubitemid 32730811)
-
(2001)
Journal of Experimental Medicine
, vol.194
, Issue.3
, pp. 375-378
-
-
Meffre, E.1
Catalan, N.2
Seltz, F.3
Fischer, A.4
Nussenzweig, M.C.5
Durandy, A.6
-
5
-
-
12744259733
-
Activation-induced deaminase: Controversies and open questions
-
Barreto, V. M., A. R. Ramiro, and M. C. Nussenzweig. 2005. Activation-induced deaminase: controversies and open questions. Trends Immunol. 26: 90-96.
-
(2005)
Trends Immunol.
, vol.26
, pp. 90-96
-
-
Barreto, V.M.1
Ramiro, A.R.2
Nussenzweig, M.C.3
-
6
-
-
1342282983
-
DNA Substrate Length and Surrounding Sequence Affect the Activation-induced Deaminase Activity at Cytidine
-
DOI 10.1074/jbc.M311616200
-
Yu, K., F. T. Huang, and M. R. Lieber. 2004. DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine. J. Biol. Chem. 279: 6496-6500. (Pubitemid 38248783)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.8
, pp. 6496-6500
-
-
Yu, K.1
Huang, F.-T.2
Lieber, M.R.3
-
7
-
-
4444239054
-
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled
-
Shen, H. M., and U. Storb. 2004. Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled. Proc. Natl. Acad. Sci. USA 101: 12997-13002.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12997-13002
-
-
Shen, H.M.1
Storb, U.2
-
8
-
-
0031569118
-
Analysis of the Frequency and Pattern of Somatic Mutations Within Nonproductively Rearranged Human Variable Heavy Chain Genes
-
Dörner, T., H. P. Brezinschek, R. I. Brezinschek, S. J. Foster, R. Domiati-Saad, and P. E. Lipsky. 1997. Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J. Immunol. 158: 2779-2789. (Pubitemid 127470537)
-
(1997)
Journal of Immunology
, vol.158
, Issue.6
, pp. 2779-2789
-
-
Dorner, T.1
Brezinschek, H.-P.2
Brezinschek, R.I.3
Foster, S.J.4
Domiati-Saad, R.5
Lipsky, P.E.6
-
11
-
-
0036786471
-
The role of polymerase η in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant
-
Yavuz, S., A. S. Yavuz, K. H. Kraemer, and P. E. Lipsky. 2002. The role of polymerase η in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant. J. Immunol. 169: 3825-3830.
-
(2002)
J. Immunol.
, vol.169
, pp. 3825-3830
-
-
Yavuz, S.1
Yavuz, A.S.2
Kraemer, K.H.3
Lipsky, P.E.4
-
12
-
-
0029063311
-
Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
-
Brezinschek, H. P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155: 190-202.
-
(1995)
J. Immunol.
, vol.155
, pp. 190-202
-
-
Brezinschek, H.P.1
Brezinschek, R.I.2
Lipsky, P.E.3
-
15
-
-
0343618461
-
Targeting and selection of mutations in human Vλ rearrangements
-
Monson, N. L., T. Dorner, and P. E. Lipsky. 2000. Targeting and selection of mutations in human Vλ rearrangements. Eur. J. Immunol. 30: 1597-1605.
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 1597-1605
-
-
Monson, N.L.1
Dorner, T.2
Lipsky, P.E.3
-
17
-
-
2442717677
-
Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER
-
Souto-Carneiro, M. M., N. S. Longo, D. E. Russ, H. W. Sun, and P. E. Lipsky. 2004. Characterization of the human Ig heavy chain antigen binding complementarity determining region 3 using a newly developed software algorithm, JOINSOLVER. J. Immunol. 172: 6790-6802.
-
(2004)
J. Immunol.
, vol.172
, pp. 6790-6802
-
-
Souto-Carneiro, M.M.1
Longo, N.S.2
Russ, D.E.3
Sun, H.W.4
Lipsky, P.E.5
-
18
-
-
0345436074
-
Molecular mechanisms and selection influence the generation of the human VλJλrepertoire
-
Farner, N. L., T. Dörner, and P. E. Lipsky. 1999. Molecular mechanisms and selection influence the generation of the human VλJλrepertoire. J. Immunol. 162: 2137-2145.
-
(1999)
J. Immunol.
, vol.162
, pp. 2137-2145
-
-
Farner, N.L.1
Dörner, T.2
Lipsky, P.E.3
-
19
-
-
0037100321
-
Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene
-
Yavuz, A. S., P. E. Lipsky, S. Yavuz, D. D. Metcalfe, and C. Akin. 2002. Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. Blood 100: 661-665.
-
(2002)
Blood
, vol.100
, pp. 661-665
-
-
Yavuz, A.S.1
Lipsky, P.E.2
Yavuz, S.3
Metcalfe, D.D.4
Akin, C.5
-
20
-
-
34248140178
-
A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus
-
Wei, C., J. Anolik, A. Cappione, B. Zheng, A. Pugh-Bernard, J. Brooks, E. H. Lee, E. C. Milner, and I. Sanz. 2007. A new population of cells lacking expression of CD27 represents a notable component of the B cell memory compartment in systemic lupus erythematosus. J. Immunol. 178: 6624-6633. (Pubitemid 46717447)
-
(2007)
Journal of Immunology
, vol.178
, Issue.10
, pp. 6624-6633
-
-
Wei, C.1
Anolik, J.2
Cappione, A.3
Zheng, B.4
Pugh-Bernard, A.5
Brooks, J.6
Lee, E.-H.7
Milner, E.C.B.8
Sanz, I.9
-
21
-
-
0026443954
-
Somatic hypermutagenesis in immunoglobulin genes: II. Influence of neighbouring base sequences on mutagenesis
-
Rogozin, I. B., and N. A. Kolchanov. 1992. Somatic hypermutagenesis in immunoglobulin genes: II. Influence of neighbouring base sequences on mutagenesis. Biochim. Biophys. Acta 1171: 11-18.
-
(1992)
Biochim. Biophys. Acta
, vol.1171
, pp. 11-18
-
-
Rogozin, I.B.1
Kolchanov, N.A.2
-
22
-
-
0031945415
-
Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human V(H)DJ(H) rearrangements
-
DOI 10.1111/j.1600-065X.1998.tb01439.x
-
Dörner, T., S. J. Foster, H. P. Brezinschek, and P. E. Lipsky. 1998. Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements. Immunol. Rev. 162: 161-171. (Pubitemid 28182133)
-
(1998)
Immunological Reviews
, vol.162
, pp. 161-171
-
-
Dorner, T.1
Foster, S.J.2
Brezinschek, H.-P.3
Lipsky, P.E.4
-
23
-
-
0031688707
-
Somatic hypermutation of human immunoglobulin heavy chain genes: Targeting of RGYW motifs on both DNA strands
-
DOI 10.1002/(SICI)1521-4141(199810)28:10<3384::AID-IMMU3384>3.0. CO;2-T
-
Dörner, T., S. J. Foster, N. L. Farner, and P. E. Lipsky. 1998. Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands. Eur. J. Immunol. 28: 3384-3396. (Pubitemid 28470285)
-
(1998)
European Journal of Immunology
, vol.28
, Issue.10
, pp. 3384-3396
-
-
Dorner, T.1
Foster, S.J.2
Farner, N.L.3
Lipsky, P.E.4
-
24
-
-
20444427642
-
DNA polymerase η contributes to strand bias of mutations of a versus T in immunoglobulin genes
-
Mayorov, V. I., I. B. Rogozin, L. R. Adkison, and P. J. Gearhart. 2005. DNA polymerase η contributes to strand bias of mutations of A versus T in immunoglobulin genes. J. Immunol. 174: 7781-7786. (Pubitemid 40806285)
-
(2005)
Journal of Immunology
, vol.174
, Issue.12
, pp. 7781-7786
-
-
Mayorov, V.I.1
Rogozin, I.B.2
Adkison, L.R.3
Gearhart, P.J.4
-
25
-
-
14244250387
-
MSH2-MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
-
Wilson, T. M., A. Vaisman, S. A. Martomo, P. Sullivan, L. Lan, F. Hanaoka, A. Yasui, R. Woodgate, and P. J. Gearhart. 2005. MSH2-MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes. J. Exp. Med. 201: 637-645.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 637-645
-
-
Wilson, T.M.1
Vaisman, A.2
Martomo, S.A.3
Sullivan, P.4
Lan, L.5
Hanaoka, F.6
Yasui, A.7
Woodgate, R.8
Gearhart, P.J.9
-
26
-
-
0035379581
-
Somatic mutation hotspots correlate with DNA polymerase η error spectrum
-
Rogozin, I. B., Y. I. Pavlov, K. Bebenek, T. Matsuda, and T. A. Kunkel. 2001. Somatic mutation hotspots correlate with DNA polymerase η error spectrum. Nat. Immunol. 2: 530-536.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 530-536
-
-
Rogozin, I.B.1
Pavlov, Y.I.2
Bebenek, K.3
Matsuda, T.4
Kunkel, T.A.5
-
27
-
-
34548526067
-
Strand-biased spreading of mutations during somatic hypermutation
-
Unniraman, S., and D. G. Schatz. 2007. Strand-biased spreading of mutations during somatic hypermutation. Science 317: 1227-1230.
-
(2007)
Science
, vol.317
, pp. 1227-1230
-
-
Unniraman, S.1
Schatz, D.G.2
-
28
-
-
20044379457
-
An update on the role of translesion synthesis DNA polymerases in Ig hypermutation
-
DOI 10.1016/j.it.2005.02.008
-
Diaz, M., and C. Lawrence. 2005. An update on the role of translesion synthesis DNA polymerases in Ig hypermutation. Trends Immunol. 26: 215-220. (Pubitemid 41556859)
-
(2005)
Trends in Immunology
, vol.26
, Issue.4
, pp. 215-220
-
-
Diaz, M.1
Lawrence, C.2
-
29
-
-
34547114028
-
-
Masuda, K., R. Ouchida, M. Hikida, T. Kurosaki, M. Yokoi, C. Masutani, M. Seki, R. D. Wood, F. Hanaoka, and O. W. J. 2007. DNA polymerases η and θ function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes. J. Biol. Chem. 282: 17387-17394.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17387-17394
-
-
Masuda, K.1
Ouchida, R.2
Hikida, M.3
Kurosaki, T.4
Yokoi, M.5
Masutani, C.6
Seki, M.7
Wood, R.D.8
Hanaoka, F.9
-
30
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
DOI 10.1038/362709a0
-
Lindahl, T. 1993. Instability and decay of the primary structure of DNA. Nature 362: 709-715. (Pubitemid 23125973)
-
(1993)
Nature
, vol.362
, Issue.6422
, pp. 709-715
-
-
Lindahl, T.1
-
31
-
-
0037026482
-
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
-
DOI 10.1038/nature00981
-
Di Noia, J., and M. S. Neuberger. 2002. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Nature 419: 43-48. (Pubitemid 34987864)
-
(2002)
Nature
, vol.419
, Issue.6902
, pp. 43-48
-
-
Di Noia, J.1
Neuberger, M.S.2
-
33
-
-
0008476550
-
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
-
McKean, D., K. Huppi, M. Bell, L. Staudt, W. Gerhard, and M. Weigert. 1984. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 81: 3180-3184. (Pubitemid 14110702)
-
(1984)
Proceedings of the National Academy of Sciences of the United States of America
, vol.81
, Issue.10 I
, pp. 3180-3184
-
-
McKean, D.1
Huppi, K.2
Bell, M.3
-
34
-
-
0035164846
-
Smaller role for pol η?
-
Dörner, T., and P. E. Lipsky. 2001. Smaller role for pol η? Nat. Immunol. 2: 982-984.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 982-984
-
-
Dörner, T.1
Lipsky, P.E.2
-
35
-
-
1842732235
-
Absence of DNA Polymerase η Reveals Targeting of C Mutations on the Nontranscribed Strand in Immunoglobulin Switch Regions
-
DOI 10.1084/jem.20032022
-
Zeng, X., G. A. Negrete, C. Kasmer, W. W. Yang, and P. J. Gearhart. 2004. Absence of DNA polymerase η reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J. Exp. Med. 199: 917-924. (Pubitemid 38481083)
-
(2004)
Journal of Experimental Medicine
, vol.199
, Issue.7
, pp. 917-924
-
-
Zeng, X.1
Negrete, G.A.2
Kasmer, C.3
Yang, W.W.4
Gearhart, P.J.5
-
36
-
-
0029943449
-
Mismatch repair in replication fidelity, genetic recombination, and cancer biology
-
Modrich, P., and R. Lahue. 1996. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65: 101-133. (Pubitemid 26250606)
-
(1996)
Annual Review of Biochemistry
, vol.65
, pp. 101-133
-
-
Modrich, P.1
Lahue, R.2
-
37
-
-
0037108463
-
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice
-
DOI 10.1016/S0960-9822(02)01215-0, PII S0960982202012150
-
Rada, C., G. T. Williams, H. Nilsen, D. E. Barnes, T. Lindahl, and M. S. Neuberger. 2002. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12: 1748-1755. (Pubitemid 35169790)
-
(2002)
Current Biology
, vol.12
, Issue.20
, pp. 1748-1755
-
-
Rada, C.1
Williams, G.T.2
Nilsen, H.3
Barnes, D.E.4
Lindahl, T.5
Neuberger, M.S.6
-
38
-
-
0142092610
-
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
-
DOI 10.1038/ni974
-
Imai, K., G. Slupphaug, W. I. Lee, P. Revy, S. Nonoyama, N. Catalan, L. Yel, M. Forveille, B. Kavli, H. E. Krokan, et al. 2003. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4: 1023-1028. (Pubitemid 37265924)
-
(2003)
Nature Immunology
, vol.4
, Issue.10
, pp. 1023-1028
-
-
Imai, K.1
Slupphaug, G.2
Lee, W.-I.3
Revy, P.4
Nonoyama, S.5
Catalan, N.6
Yel, L.7
Forveille, M.8
Kavli, B.9
Krokan, H.E.10
Ochs, H.D.11
Fischer, A.12
Durandy, A.13
-
39
-
-
0025344222
-
A sensitive genetic assay for the detection of cytosine deamination: Determination of rate constants and the activation energy
-
Frederico, L. A., T. A. Kunkel, and B. R. Shaw. 1990. A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy. Biochemistry 29: 2532-2537.
-
(1990)
Biochemistry
, vol.29
, pp. 2532-2537
-
-
Frederico, L.A.1
Kunkel, T.A.2
Shaw, B.R.3
-
40
-
-
33846404877
-
DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
-
DOI 10.1084/jem.20062131
-
Delbos, F., S. Aoufouchi, A. Faili, J. C. Weill, and C. A. Reynaud. 2007. DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse. J. Exp. Med. 204: 17-23. (Pubitemid 46148751)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.1
, pp. 17-23
-
-
Delbos, F.1
Aoufouchi, S.2
Faili, A.3
Weill, J.-C.4
Reynaud, C.-A.5
-
41
-
-
0032006753
-
B cell superantigens: Possible roles in immunodeficiency and autoimmunity
-
Silverman, G. J. 1998. B cell superantigens: possible roles in immunodeficiency and autoimmunity. Semin. Immunol. 10: 43-55.
-
(1998)
Semin. Immunol.
, vol.10
, pp. 43-55
-
-
Silverman, G.J.1
|