A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.

Molecular pharmaceutics

Volumn 1, Issue 2, 2004, Pages 117-127

  Kim, Insook ^a   Song, Xueqin ^a   Vig, Balvinder S ^a   Mittal, Sachin ^a   Shin, Ho Chul ^a   Lorenzi, Philip J ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; BPHL PROTEIN, HUMAN; CARBOXYLESTERASE; DRUG DERIVATIVE; GANCICLOVIR; HYBRID PROTEIN; PRODRUG; VALACICLOVIR; VALGANCICLOVIR; VALINE;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; DRUG DESIGN; ENZYME ACTIVATION; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENETIC VARIABILITY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

ACYCLOVIR; AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; CARBOXYLIC ESTER HYDROLASES; CLONING, MOLECULAR; DRUG DESIGN; ENZYME ACTIVATION; ESCHERICHIA COLI; GANCICLOVIR; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PRODRUGS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; VALINE; VARIATION (GENETICS);

MLCS; MLOWN;

EID: 18044367552     PISSN: 15438384     EISSN: None     Source Type: Journal    
DOI: 10.1021/mp0499757     Document Type: Article

References (0)