hPEPT1 affinity and translocation of selected Gln-Sar and Glu-Sar dipeptide derivatives

Molecular Pharmaceutics

Volumn 2, Issue 3, 2005, Pages 242-249

  Eriksson, André Huss ^a   Elm, Peter L ^a   Begtrup, Mikael ^a   Nielsen, Robert ^b   Steffansen, Bente ^a   Brodin, Birger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

BCECF; Caco 2; Dipeptide derivatives; Epifluorescence microscopy; hPEPT1; Intracellular pH

Indexed keywords

BUTYLOXYCARBONYLGLUTAMINYL (N PIPERIDINYL)SARCOSINE O TERT BUTYL AMIDE; BUTYLOXYCARBONYLGLUTAMINYL (N,N DIMETHYL)SARCOSINE O TERT BUTYL AMIDE; BUTYLOXYCARBONYLGLUTAMYL (O ADAMANTYLMETHANOL)SARCOSINE O TERT BUTYL ESTER; BUTYOXYCARBONYLGLUTAMYL (O ISOBUTYL)SARCOSINE O TERT BUTYL ESTER; DIPEPTIDE DERIVATIVE; GLUTAMINYLSARCOSINE DERIVATIVE; GLUTAMYLSARCOSINE DERIVATIVE; PEPTIDE TRANSPORTER 1; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG SYNTHESIS; EPIFLUORESCENCE MICROSCOPY; FLUORESCENCE; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMIDES; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DIPEPTIDES; ESTERS; GLUTAMIC ACID; GLUTAMINE; HOMEODOMAIN PROTEINS; HUMANS; PRODRUGS; PROTEIN TRANSPORT; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SARCOSINE;

EID: 21444452619     PISSN: 15438384     EISSN: None     Source Type: Journal    
DOI: 10.1021/mp050015+     Document Type: Article

References (17)

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