Identification of a human valacyclovirase: Biphenyl hydrolase-like protein as valacyclovir hydrolase

Journal of Biological Chemistry

Volumn 278, Issue 28, 2003, Pages 25348-25356

  Kim, Insook ^d   Chu, Xiao Yan ^a   Kim, Seonyoung ^b   Provoda, Chester J ^d   Lee, Kyung Dall ^d   Amidon, Gordon L ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ALLERGAN INC   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; CLONING; DRUG THERAPY; HYDROLYSIS;

BIOAVAILABILITY;

ENZYMES;

4 CHLOROMERCURIBENZOIC ACID; ACICLOVIR; BESTATIN; BIPHENYL HYDROLASE LIKE PROTEIN; CAPTOPRIL; DYFLOS; EDETIC ACID; ESTER DERIVATIVE; HYDROLASE; PARAOXON; PHYSOSTIGMINE; PRODRUG; PROTEIN DERIVATIVE; RECOMBINANT PROTEIN; SERINE DEHYDRATASE; UNCLASSIFIED DRUG; VALACICLOVIR; VALACYCLOVIR HYDROLASE; VALACYCLOVIRASE; VALGANCICLOVIR; ZIDOVUDINE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME PURIFICATION; HUMAN; HUMAN CELL; HYDROLYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

NON-PROGRAMMATIC;

ACYCLOVIR; AMINO ACID SEQUENCE; BLOTTING, WESTERN; CARBOXYLIC ESTER HYDROLASES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLASES; HYDROLYSIS; INTESTINES; KINETICS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; VALINE;

ANIMALIA;

EID: 0037815496     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M302055200     Document Type: Article

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