Structure-affinity relationships of Val-Val and Val-Val-Val stereoisomers with the apical oligopeptide transporter in human intestinal Caco-2 cells

Journal of Drug Targeting

Volumn 5, Issue 5, 1998, Pages 317-327

  Li, Jibin ^a,d   Tamura, Kiyoshi ^b,e   Lee, Chao Pin ^c   Smith, Philip L ^c   Borchardt, Ronald T ^b   Hidalgo, Ismael J ^a,f  

^a SANOFI   (France)

^b UNIVERSITY OF KANSAS   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d AMGEN INC   (United States)

^e JAPAN TOBACCO INC   (Japan)

^f Absorption Systems   (United States)

Author keywords

Caco 2; Molecular modeling; Oligopeptide transporter; Structure transport

Indexed keywords

CARBOXYL GROUP; CARRIER PROTEIN; CEFALEXIN; OLIGOPEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL STRAIN CACO 2; COMPUTER PROGRAM; CONFORMATION; CONTROLLED STUDY; DIPOLE; HUMAN; HUMAN CELL; INTESTINE CELL; MOLECULAR MODEL; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; VARIANCE;

EID: 0031689519     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869808997860     Document Type: Article

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