-
1
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A et al. (2007) Cancer statistics, 2007. CA Cancer J Clin 57: 43-66
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
-
2
-
-
0030931974
-
A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal carcinoma
-
Machover D (1997) A comprehensive review of 5-fluorouracil and leucovorin in patients with metastatic colorectal carcinoma. Cancer 80: 1179-1187
-
(1997)
Cancer
, vol.80
, pp. 1179-1187
-
-
Machover, D.1
-
3
-
-
0031014682
-
Thymidylate synthase inhibitors in cancer therapy: Direct and indirect inhibitors
-
Rustum YM et al. (1997) Thymidylate synthase inhibitors in cancer therapy: Direct and indirect inhibitors. J Clin Oncol 15: 389-400
-
(1997)
J Clin Oncol
, vol.15
, pp. 389-400
-
-
Rustum, Y.M.1
-
4
-
-
0344109583
-
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
-
Meta-analysis Group in Cancer
-
Meta-analysis Group in Cancer (1998) Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 16: 301-308
-
(1998)
J Clin Oncol
, vol.16
, pp. 301-308
-
-
-
5
-
-
0032792959
-
Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
-
Popescu RA et al. (1999) Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 17: 2412-2418
-
(1999)
J Clin Oncol
, vol.17
, pp. 2412-2418
-
-
Popescu, R.A.1
-
6
-
-
2542615200
-
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
-
André T et al. (2004) Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Mad 350: 2343-2351
-
(2004)
N Engl J Mad
, vol.350
, pp. 2343-2351
-
-
André, T.1
-
7
-
-
34250629236
-
UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan
-
Cote JF et al. (2007) UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan. Clin Cancer Res 13: 3269-3275
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3269-3275
-
-
Cote, J.F.1
-
8
-
-
0035912144
-
Molecular predictors of survival after adjuvant chemotherapy for colon cancer
-
Watanabe T et al. (2001) Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 344: 1196-1206
-
(2001)
N Engl J Med
, vol.344
, pp. 1196-1206
-
-
Watanabe, T.1
-
9
-
-
0032950293
-
Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer
-
International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT 132) Investigators
-
International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT 132) Investigators (1999) Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. J Clin Oncol 17: 1356-1363
-
(1999)
J Clin Oncol
, vol.17
, pp. 1356-1363
-
-
-
10
-
-
0028219974
-
Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer: Advanced Colorectal Cancer Meta-Analysis Project
-
[No authors listed] (1994) Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer: Advanced Colorectal Cancer Meta-Analysis Project. J Clin Oncol 12: 960-969
-
(1994)
J Clin Oncol
, vol.12
, pp. 960-969
-
-
-
11
-
-
34548488936
-
Phase III study comparing a semimonthly with a monthly regimen of fluorouracil and leucovorin as adjuvant treatment for stage II and III colon Cancer patients: Final results of GERCOR C96.1
-
André T et al. (2007) Phase III study comparing a semimonthly with a monthly regimen of fluorouracil and leucovorin as adjuvant treatment for stage II and III colon Cancer patients: Final results of GERCOR C96.1. J Clin Oncol 25: 3732-3738
-
(2007)
J Clin Oncol
, vol.25
, pp. 3732-3738
-
-
André, T.1
-
12
-
-
0028175144
-
Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
-
Buroker TR et al. (1994) Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 12: 14-20
-
(1994)
J Clin Oncol
, vol.12
, pp. 14-20
-
-
Buroker, T.R.1
-
13
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
for the Irinotecan Study Group
-
Saltz LB et al. for the Irinotecan Study Group (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343: 905-914
-
(2000)
N Engl J Med
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
-
14
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
-
Douillard JY et al. (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial. Lancet 355 1041-1047
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
-
15
-
-
0041055512
-
Randomised multicentre trial of oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer
-
Levi F et al. (1997) Randomised multicentre trial of oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. Lancet 350: 681-686
-
(1997)
Lancet
, vol.350
, pp. 681-686
-
-
Levi, F.1
-
16
-
-
85081430317
-
Recommendation for caution with irinotecan fluorouracil and leucovorin for colorectal cancer
-
Sargent DJ et al. (2001) Recommendation for caution with irinotecan fluorouracil and leucovorin for colorectal cancer. N Eng J Med 345: 690-692
-
(2001)
N Eng J Med
, vol.345
, pp. 690-692
-
-
Sargent, D.J.1
-
17
-
-
0035281522
-
Irinotecan in the treatment of colorectal cancer: Clinical overview
-
Vanhoefer U et al. (2001) Irinotecan in the treatment of colorectal cancer: Clinical overview. J Clin Oncol 19: 1501-1518
-
(2001)
J Clin Oncol
, vol.19
, pp. 1501-1518
-
-
Vanhoefer, U.1
-
18
-
-
0031056423
-
Phase II study of trimetrexate, fluorouracil, and leucovorin for advanced colorectal cancer
-
Blanke C et al. (1997) Phase II study of trimetrexate, fluorouracil, and leucovorin for advanced colorectal cancer. J Clin Oncol 15: 915-920
-
(1997)
J Clin Oncol
, vol.15
, pp. 915-920
-
-
Blanke, C.1
-
19
-
-
0024834136
-
Fluorouracil and recombinant alfa-2a-interferon: An active regimen against advanced colorectal carcinoma
-
Wadler S et al. (1989) Fluorouracil and recombinant alfa-2a-interferon: An active regimen against advanced colorectal carcinoma. J Clin Oncol 7: 1769-1775
-
(1989)
J Clin Oncol
, vol.7
, pp. 1769-1775
-
-
Wadler, S.1
-
20
-
-
0026006962
-
Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
-
Poon M et al. (1991) Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 9: 1967-1972
-
(1991)
J Clin Oncol
, vol.9
, pp. 1967-1972
-
-
Poon, M.1
-
21
-
-
0345596364
-
Toxicity of fluorouracil with advanced colorectal cancer: Effect of administration schedule and prognostic factors
-
The Meta-Analysis Group in Cancer
-
The Meta-Analysis Group in Cancer (1998) Toxicity of fluorouracil with advanced colorectal cancer: Effect of administration schedule and prognostic factors. J Clin Oncol 16: 3537-3541
-
(1998)
J Clin Oncol
, vol.16
, pp. 3537-3541
-
-
-
22
-
-
0034596549
-
Palliative chemotherapy for advanced colorectal cancer systematic review and meta-analysis
-
for the Colorectal Cancer Collaborative Group
-
Simmonds PC et al. for the Colorectal Cancer Collaborative Group (2000) Palliative chemotherapy for advanced colorectal cancer systematic review and meta-analysis. BMJ 321: 531-535
-
(2000)
BMJ
, vol.321
, pp. 531-535
-
-
Simmonds, P.C.1
-
23
-
-
0037087563
-
Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer
-
Sloan JA et al. (2002) Women experience greater toxicity with fluorouracil-based chemotherapy for colorectal cancer. J Clin Oncol 20: 1491-1498
-
(2002)
J Clin Oncol
, vol.20
, pp. 1491-1498
-
-
Sloan, J.A.1
-
24
-
-
0028819554
-
Age and sex are independent predictors of 5-fluorouracil toxicity
-
Stein BN et al. (1995) Age and sex are independent predictors of 5-fluorouracil toxicity. Cancer 75: 11-17
-
(1995)
Cancer
, vol.75
, pp. 11-17
-
-
Stein, B.N.1
-
25
-
-
0026636184
-
Influence of sex and age on fluorouracil clearance
-
Milano G et al. (1992) Influence of sex and age on fluorouracil clearance. J Clin Oncol 10: 1171-1175
-
(1992)
J Clin Oncol
, vol.10
, pp. 1171-1175
-
-
Milano, G.1
-
26
-
-
0032211354
-
Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number
-
for the Tomudex International Study Group
-
Zalcberg J et al. for the Tomudex International Study Group (1998) Haematological and non-haematological toxicity after 5-fluorouracil and leucovorin in patients with advanced colorectal cancer is significantly associated with gender, increasing age and cycle number. Eur J Cancer 34: 1871-1875
-
(1998)
Eur J Cancer
, vol.34
, pp. 1871-1875
-
-
Zalcberg, J.1
-
27
-
-
1442332174
-
Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer findings from Intergroup Trial 0114
-
Meyerhardt JA et al. (2004) Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer findings from Intergroup Trial 0114. J Clin Oncol 22: 648-657
-
(2004)
J Clin Oncol
, vol.22
, pp. 648-657
-
-
Meyerhardt, J.A.1
-
28
-
-
0037313036
-
Impact of diabetes mellitus on outcomes in patients with colon cancer
-
Meyerhardt JA et al. (2003) Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol 21: 433-440
-
(2003)
J Clin Oncol
, vol.21
, pp. 433-440
-
-
Meyerhardt, J.A.1
-
29
-
-
0037036689
-
Outcomes and toxicity in African-American and Caucasian patients in a randomized adjuvant chemotherapy trial for colon cancer
-
McCollum AD et al. (2002) Outcomes and toxicity in African-American and Caucasian patients in a randomized adjuvant chemotherapy trial for colon cancer. J Natl Cancer Inst 94: 1160-1167
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1160-1167
-
-
McCollum, A.D.1
-
30
-
-
33749350447
-
Increased prevalence of dihydropyrimidine dehydrogenase deficiency in African-Americans compared with Caucasians
-
Mattison LK et al. (2006) Increased prevalence of dihydropyrimidine dehydrogenase deficiency in African-Americans compared with Caucasians. Clin Cancer Res 12: 5491-5495
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5491-5495
-
-
Mattison, L.K.1
-
31
-
-
0026793052
-
Purification and characterization of dihydropyrimidine dehydrogenase from human liver
-
Lu Z et al. (1992) Purification and characterization of dihydropyrimidine dehydrogenase from human liver. J Biol Chem 267: 17102-17109
-
(1992)
J Biol Chem
, vol.267
, pp. 17102-17109
-
-
Lu, Z.1
-
32
-
-
0031790577
-
The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology
-
Diasio RB (1998) The role of dihydropyrimidine dehydrogenase (DPD) modulation in 5-FU pharmacology. Oncology 12 (Suppl 7): S23-S27
-
(1998)
Oncology
, vol.12
, Issue.SUPPL. 7
-
-
Diasio, R.B.1
-
33
-
-
0023187085
-
Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
-
Heggie GC et al. (1987) Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 47: 2203-2206
-
(1987)
Cancer Res
, vol.47
, pp. 2203-2206
-
-
Heggie, G.C.1
-
34
-
-
0025058867
-
Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
-
Harris BE et al. (1990) Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 50: 197-201
-
(1990)
Cancer Res
, vol.50
, pp. 197-201
-
-
Harris, B.E.1
-
35
-
-
0028805308
-
Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy
-
Lu Z et al. (1995) Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy. Clin Pharmacol Ther 58: 512-522
-
(1995)
Clin Pharmacol Ther
, vol.58
, pp. 512-522
-
-
Lu, Z.1
-
36
-
-
0034488052
-
Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: Identification of new mutations in the DPD gene
-
van Kuilenburg AB et al. (2000) Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: Identification of new mutations in the DPD gene. Clin Cancer Res 6: 4705-4712
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4705-4712
-
-
van Kuilenburg, A.B.1
-
37
-
-
0034808681
-
Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 50-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls
-
Raida M et al. (2001) Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 50-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls. Clin Cancer Res 7: 2832-2839
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2832-2839
-
-
Raida, M.1
-
38
-
-
0000163968
-
Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity
-
Milano G et al. (1999) Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity. Br J Cancer 79: 627-630
-
(1999)
Br J Cancer
, vol.79
, pp. 627-630
-
-
Milano, G.1
-
39
-
-
0032795865
-
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil
-
Johnson MR et al. (1999) Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res 5: 2006-2011
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2006-2011
-
-
Johnson, M.R.1
-
40
-
-
0034901306
-
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil >A mutation causing DPD deficiency
-
van Kuilenburg AB et al. (2001) Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: Frequency of the common IVS14+1G>A mutation causing DPD deficiency Clin Cancer Res 7: 1149-1153
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1149-1153
-
-
van Kuilenburg, A.B.1
-
41
-
-
0029973215
-
Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity
-
Wei X et al. (1996) Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity. J Clin Invest 98: 610-615
-
(1996)
J Clin Invest
, vol.98
, pp. 610-615
-
-
Wei, X.1
-
42
-
-
0023902287
-
Familial deficiency of dihydropyrimidine dehydrogenase
-
Diasio RB et al. (1988) Familial deficiency of dihydropyrimidine dehydrogenase. J Clin Investig 81: 47-51
-
(1988)
J Clin Investig
, vol.81
, pp. 47-51
-
-
Diasio, R.B.1
-
43
-
-
47849131155
-
The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer
-
doi: 10.1038/sj.tpj.6500476
-
Capitain O et al. (2007) The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer. Pharmacogenomics J [doi: 10.1038/sj.tpj.6500476]
-
(2007)
Pharmacogenomics J
-
-
Capitain, O.1
-
44
-
-
0023134446
-
Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA
-
Kaneda S et al. (1987) Role in translation of a triple tandemly repeated sequence in the 5'-untranslated region of human thymidylate synthase mRNA. Nucleic Acids Res 15: 1259-1270
-
(1987)
Nucleic Acids Res
, vol.15
, pp. 1259-1270
-
-
Kaneda, S.1
-
45
-
-
0029122937
-
Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase
-
Horie N et al. (1995) Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5'-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 20 191-197
-
(1995)
Cell Struct Funct
, vol.20
, pp. 191-197
-
-
Horie, N.1
-
46
-
-
0034548477
-
Novel thymidylate synthase enhancer region alleles in African populations
-
Marsh S et al. (2000) Novel thymidylate synthase enhancer region alleles in African populations. Hum Mutat 16: 528
-
(2000)
Hum Mutat
, vol.16
, pp. 528
-
-
Marsh, S.1
-
47
-
-
0035750549
-
Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy
-
Pullarkat ST et al. (2001) Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 1: 65-70
-
(2001)
Pharmacogenomics J
, vol.1
, pp. 65-70
-
-
Pullarkat, S.T.1
-
48
-
-
4444339951
-
Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
-
Lecomte T et al. (2004) Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 10: 5880-5888
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5880-5888
-
-
Lecomte, T.1
-
49
-
-
8344245563
-
Thymidylate synthase expression in normal colonic mucosa: A predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy
-
Santini D et al. (2004) Thymidylate synthase expression in normal colonic mucosa: A predictive marker of toxicity in colorectal cancer patients receiving 5-fluorouracil-based adjuvant chemotherapy. Oncology 67: 135-142
-
(2004)
Oncology
, vol.67
, pp. 135-142
-
-
Santini, D.1
-
50
-
-
0035313224
-
Biological and clinical implications of the MTHFR C677T polymorphism
-
Ueland PM et al. (2001) Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 22: 195-201
-
(2001)
Trends Pharmacol Sci
, vol.22
, pp. 195-201
-
-
Ueland, P.M.1
-
51
-
-
0035552975
-
Polymorphisms in the methylenetetrahydrofolate reductase gene: Clinical consequences
-
Schwahn B and Rozen R (2001) Polymorphisms in the methylenetetrahydrofolate reductase gene: Clinical consequences. Am J Pharmacogenomics 1: 189-201
-
(2001)
Am J Pharmacogenomics
, vol.1
, pp. 189-201
-
-
Schwahn, B.1
Rozen, R.2
-
52
-
-
0032573077
-
A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells
-
Bagley PJ and Selhub J (1998) A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 95: 13217-13220
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13217-13220
-
-
Bagley, P.J.1
Selhub, J.2
-
53
-
-
0035886707
-
Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancer
-
Stevenson JP et al. (2001) Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancer. J Clin Oncol 19: 4081-4087
-
(2001)
J Clin Oncol
, vol.19
, pp. 4081-4087
-
-
Stevenson, J.P.1
-
54
-
-
0033998678
-
MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil
-
Toffoli G et al. (2000) MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil. Ann Oncol 11 373-374
-
(2000)
Ann Oncol
, vol.11
, pp. 373-374
-
-
Toffoli, G.1
-
55
-
-
4243254839
-
Pharmacogenetics in cancer chemotherapy: 677C-T methylenetetra-hydrofolate reductase (MTHFR) gene polymorphism and toxicity after cyclophosphamide, methotrexate, and 5-fluorouracil (CMF)
-
4555s
-
Toffoli G et al. (2000) Pharmacogenetics in cancer chemotherapy: 677C-T methylenetetra-hydrofolate reductase (MTHFR) gene polymorphism and toxicity after cyclophosphamide, methotrexate, and 5-fluorouracil (CMF). Clin Cancer Res 6: 4555s
-
(2000)
Clin Cancer Res
, vol.6
-
-
Toffoli, G.1
-
56
-
-
33746102909
-
Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen
-
Ichikawa W et al. (2006) Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen. Clin Cancer Res 12: 3928-3934
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3928-3934
-
-
Ichikawa, W.1
-
57
-
-
48749116309
-
Pharmacokinetics (PK) and pharmacodynamics (PD) of capecitabine in two phase I studies
-
abstract #1509, Philadelphia, PA. Alexandria, VA: ASCO Publications
-
Twelves C et al. (1996) Pharmacokinetics (PK) and pharmacodynamics (PD) of capecitabine in two phase I studies [abstract #1509]. In Proceedings of the American Society of Clinical Oncology Annual Meeting: 1996 May 18-21, Philadelphia, PA. Alexandria, VA: ASCO Publications
-
(1996)
Proceedings of the American Society of Clinical Oncology Annual Meeting: 1996 May 18-21
-
-
Twelves, C.1
-
58
-
-
48749112446
-
Toxicity of oral fluoropyrimidines is predictable by dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cell
-
abstract #617, Orlando, FL. Alexandria, VA: ASCO Publications
-
Terashima M et al. (2002) Toxicity of oral fluoropyrimidines is predictable by dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cell [abstract #617]. In Proceedings of the American Society of Clinical Oncology Annual Meeting: 2002 May 18-21, Orlando, FL. Alexandria, VA: ASCO Publications
-
(2002)
Proceedings of the American Society of Clinical Oncology Annual Meeting: 2002 May 18-21
-
-
Terashima, M.1
-
59
-
-
33845691987
-
The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil
-
Jensen SA et al. (2007) The prognostic significance of thymidylate synthase and dihydropyrimidine dehydrogenase in colorectal cancer of 303 patients adjuvantly treated with 5-fluorouracil. Int J Cancer 120: 694-701
-
(2007)
Int J Cancer
, vol.120
, pp. 694-701
-
-
Jensen, S.A.1
-
60
-
-
33645742923
-
A phase II study of fixed-dose capecitabine and assessment of predictors of toxicity in patients with advanced/ metastatic colorectal cancer
-
Sharma R et al. (2006) A phase II study of fixed-dose capecitabine and assessment of predictors of toxicity in patients with advanced/ metastatic colorectal cancer. Br J Cancer 94: 964-968
-
(2006)
Br J Cancer
, vol.94
, pp. 964-968
-
-
Sharma, R.1
-
61
-
-
0026600884
-
Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice
-
Kim R et al. (1992) Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice. Int J Cancer 50: 760-766
-
(1992)
Int J Cancer
, vol.50
, pp. 760-766
-
-
Kim, R.1
-
62
-
-
0027447420
-
The current status of camptothecin analogues as antitumor agents
-
Slichenmyer WJ et al. (1993) The current status of camptothecin analogues as antitumor agents. J Natl Cancer Inst 85: 271-291
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 271-291
-
-
Slichenmyer, W.J.1
-
63
-
-
0028225471
-
Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials
-
Tanizawa A et al. (1994) Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials. J Natl Cancer Inst 86: 836-842
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 836-842
-
-
Tanizawa, A.1
-
64
-
-
0024537205
-
Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity
-
Hertzberg RP et al. (1989) Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity. J Med Chem 32: 715-720
-
(1989)
J Med Chem
, vol.32
, pp. 715-720
-
-
Hertzberg, R.P.1
-
65
-
-
0025996996
-
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11
-
Kawato Y et al. (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51: 4187-4191
-
(1991)
Cancer Res
, vol.51
, pp. 4187-4191
-
-
Kawato, Y.1
-
66
-
-
0027584926
-
Cytogenetic effects of CPT-11 and its active metabolite, SN-38 on human lymphocytes
-
Kojima A et al. (1993) Cytogenetic effects of CPT-11 and its active metabolite, SN-38 on human lymphocytes. Jpn J Clin Oncol 23: 116-22
-
(1993)
Jpn J Clin Oncol
, vol.23
, pp. 116-122
-
-
Kojima, A.1
-
67
-
-
0027242140
-
Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11
-
Araki E et al. (1993) Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11. Jpn J Cancer Res 84: 697-702
-
(1993)
Jpn J Cancer Res
, vol.84
, pp. 697-702
-
-
Araki, E.1
-
68
-
-
0025129894
-
An early phase II study of CPT-11: A new derivative of camptothecin, for the treatment of leukemia and lymphoma
-
Ohno R et al. (1990) An early phase II study of CPT-11: A new derivative of camptothecin, for the treatment of leukemia and lymphoma. J Clin Oncol 8: 1907-1912
-
(1990)
J Clin Oncol
, vol.8
, pp. 1907-1912
-
-
Ohno, R.1
-
69
-
-
0025851286
-
Phase I study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer
-
Negoro S et al. (1991) Phase I study of weekly intravenous infusions of CPT-11, a new derivative of camptothecin, in the treatment of advanced non-small-cell lung cancer. J Natl Cancer Inst 83 1164-1168
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 1164-1168
-
-
Negoro, S.1
-
70
-
-
0028843263
-
Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11
-
Sasaki Y et al. (1995) Pharmacological correlation between total drug concentration and lactones of CPT-11 and SN-38 in patients treated with CPT-11. Jpn J Cancer Res 86: 111-116
-
(1995)
Jpn J Cancer Res
, vol.86
, pp. 111-116
-
-
Sasaki, Y.1
-
72
-
-
0032519431
-
Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of UGT 1AQ in the glucuronidation of its active metabolite (SN38) in human liver microsomes
-
Iyer L et al. (1998) Genetic predisposition to the metabolism of irinotecan (CPT-11): Role of UGT 1AQ in the glucuronidation of its active metabolite (SN38) in human liver microsomes. J Clin Invest 101: 847-854
-
(1998)
J Clin Invest
, vol.101
, pp. 847-854
-
-
Iyer, L.1
-
73
-
-
0030030762
-
Genetic variation in bilirubin UDP-glycuronyltransferase gene promoter and Gilbert's syndrome
-
Monaghan G et al. (1996) Genetic variation in bilirubin UDP-glycuronyltransferase gene promoter and Gilbert's syndrome. Lancet 347: 578-581
-
(1996)
Lancet
, vol.347
, pp. 578-581
-
-
Monaghan, G.1
-
74
-
-
0032493441
-
Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter - a balanced polymorphism for regulation of bilirubin metabolism?
-
Beutler E et al. (1998) Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter - a balanced polymorphism for regulation of bilirubin metabolism? Proc Natl Acad Sci USA 95: 8170-8174
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8170-8174
-
-
Beutler, E.1
-
75
-
-
0036025450
-
UGT1A1°28 polymorphism as a determinant of irinotecan disposition and toxicity
-
Iyer L et al. (2002) UGT1A1°28 polymorphism as a determinant of irinotecan disposition and toxicity. Pharmacogenomics J 2: 43-47
-
(2002)
Pharmacogenomics J
, vol.2
, pp. 43-47
-
-
Iyer, L.1
-
76
-
-
0030716924
-
Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports
-
Wasserman E et al. (1997) Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports. Ann Oncol 8: 1049-1051
-
(1997)
Ann Oncol
, vol.8
, pp. 1049-1051
-
-
Wasserman, E.1
-
77
-
-
33644525291
-
Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy
-
Massacesi C et al. (2006) Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy. Cancer 106: 1007-1016
-
(2006)
Cancer
, vol.106
, pp. 1007-1016
-
-
Massacesi, C.1
-
78
-
-
0032249640
-
Irinotecan pharmacokinetics
-
Chabot GG et al. (1998) Irinotecan pharmacokinetics. Bull Cancer 11-20
-
(1998)
Bull Cancer
, pp. 11-20
-
-
Chabot, G.G.1
-
79
-
-
0032533498
-
Biliary excretion mechanism of CPT-11 and its metabolites in humans: Involvement of primary active transporters
-
Chu XY et al. (1998) Biliary excretion mechanism of CPT-11 and its metabolites in humans: Involvement of primary active transporters. Cancer Res 58: 5137-5143
-
(1998)
Cancer Res
, vol.58
, pp. 5137-5143
-
-
Chu, X.Y.1
-
80
-
-
33749160663
-
Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients
-
Romero RZ et al. (2006) Potential application of GSTT1-null genotype in predicting toxicity associated to 5-fluouracil irinotecan and leucovorin regimen in advanced stage colorectal cancer patients. Oncol Rep 16: 497-503
-
(2006)
Oncol Rep
, vol.16
, pp. 497-503
-
-
Romero, R.Z.1
-
81
-
-
0032443235
-
Irinotecan: Various administration schedules, study of drug combinations, phase I experience
-
Boige V et al. (1998) Irinotecan: Various administration schedules, study of drug combinations, phase I experience. Bull Cancer 26-32
-
(1998)
Bull Cancer
, pp. 26-32
-
-
Boige, V.1
-
82
-
-
0025020085
-
Phase I study of oxaliplatin in patients with advanced cancer
-
Extra JM et al. (1990) Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol 25: 299-303
-
(1990)
Cancer Chemother Pharmacol
, vol.25
, pp. 299-303
-
-
Extra, J.M.1
-
83
-
-
2342584118
-
Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer
-
Meyerhardt JA et al. (2004) Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer. J Clin Oncol 22: 1439-1446
-
(2004)
J Clin Oncol
, vol.22
, pp. 1439-1446
-
-
Meyerhardt, J.A.1
-
84
-
-
21744443122
-
Clinical management of oxaliplatinassociated neurotoxicity
-
Grothey A (2005) Clinical management of oxaliplatinassociated neurotoxicity. Clin Colorectal Cancer 5 (suppl 1): S38-S46
-
(2005)
Clin Colorectal Cancer
, vol.5
, Issue.SUPPL. 1
-
-
Grothey, A.1
-
85
-
-
0031741679
-
Oxaliplatin: A review of preclinical and clinical studies
-
Raymond E et al. (1998) Oxaliplatin: A review of preclinical and clinical studies. Ann Oncol 9: 1053-1071
-
(1998)
Ann Oncol
, vol.9
, pp. 1053-1071
-
-
Raymond, E.1
-
86
-
-
0142054688
-
Recurrent episodes of involuntary masticatory spasms induced by continuous infusion of oxaliplatin
-
Santini D et al. (2003) Recurrent episodes of involuntary masticatory spasms induced by continuous infusion of oxaliplatin. J Natl Cancer Inst 95: 1555-1556
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 1555-1556
-
-
Santini, D.1
-
87
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
De Gramont A et al. (2000) Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18: 2938-2947
-
(2000)
J Clin Oncol
, vol.18
, pp. 2938-2947
-
-
De Gramont, A.1
-
89
-
-
0034613403
-
The chemotherapeutic oxaliplatin alters voltage-gated Na(+) channel kinetics on rat sensory neurons
-
Adelsberger H et al. (2000) The chemotherapeutic oxaliplatin alters voltage-gated Na(+) channel kinetics on rat sensory neurons. Eur J Pharmacol 406: 25-32
-
(2000)
Eur J Pharmacol
, vol.406
, pp. 25-32
-
-
Adelsberger, H.1
-
90
-
-
0033962280
-
Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs
-
Screnci D et al. (2000) Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs. Br J Cancer 82: 966-972
-
(2000)
Br J Cancer
, vol.82
, pp. 966-972
-
-
Screnci, D.1
-
91
-
-
34548059736
-
Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function
-
Takimoto CH et al. (2007) Oxaliplatin pharmacokinetics and pharmacodynamics in adult cancer patients with impaired renal function. Clin Cancer Res 13: 4832-4839
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4832-4839
-
-
Takimoto, C.H.1
-
92
-
-
0035003714
-
A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels
-
Grolleau F et al. (2001) A possible explanation for a neurotoxic effect of the anticancer agent oxaliplatin on neuronal voltage-gated sodium channels. J Neurophysiol 85: 2293-2297
-
(2001)
J Neurophysiol
, vol.85
, pp. 2293-2297
-
-
Grolleau, F.1
-
93
-
-
0033790788
-
Early biotransformations of oxaliplatin after its intravenous administration to cancer patients
-
Allain P et al. (2000) Early biotransformations of oxaliplatin after its intravenous administration to cancer patients. Drug Metab Dispos 28: 1379-1384
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 1379-1384
-
-
Allain, P.1
-
94
-
-
0042631396
-
Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: A National Cancer Institute Organ Dysfunction Working Group study
-
Takimoto CH et al. (2003) Dose-escalating and pharmacological study of oxaliplatin in adult cancer patients with impaired renal function: A National Cancer Institute Organ Dysfunction Working Group study. J Clin Oncol 21: 2664-2672
-
(2003)
J Clin Oncol
, vol.21
, pp. 2664-2672
-
-
Takimoto, C.H.1
-
95
-
-
0034006524
-
Clinical pharmacokinetics of oxaliplatin: A critical review
-
Graham MA et al. (2000) Clinical pharmacokinetics of oxaliplatin: a critical review. Clin Cancer Res 6: 1205-1218
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1205-1218
-
-
Graham, M.A.1
-
96
-
-
0036270715
-
Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: An active and low toxicity regimen
-
Feliu J et al. (2002) Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: An active and low toxicity regimen. Eur J Cancer 38: 1204-1211
-
(2002)
Eur J Cancer
, vol.38
, pp. 1204-1211
-
-
Feliu, J.1
-
97
-
-
0036765690
-
Tolerability of raltitrexed ('Tomudex') in elderly patients with colorectal cancer
-
Romiti A et al. (2002) Tolerability of raltitrexed ('Tomudex') in elderly patients with colorectal cancer. Anticancer Res 22: 3071-3076
-
(2002)
Anticancer Res
, vol.22
, pp. 3071-3076
-
-
Romiti, A.1
-
98
-
-
0034663174
-
Fatal liver failure after the administration of raltitrexed for cancer chemotherapy: A report of two cases
-
Raderer M et al. (2000) Fatal liver failure after the administration of raltitrexed for cancer chemotherapy: A report of two cases. Cancer 89: 890-892
-
(2000)
Cancer
, vol.89
, pp. 890-892
-
-
Raderer, M.1
-
99
-
-
0030823834
-
Overview of the tolerability of 'Tomudex' (raltitrexed): Collective clinical experience in advanced colorectal cancer
-
Zalcberg J (1997) Overview of the tolerability of 'Tomudex' (raltitrexed): Collective clinical experience in advanced colorectal cancer. Anticancer Drugs 8 (suppl 2): S17-S22
-
(1997)
Anticancer Drugs
, vol.8
, Issue.SUPPL. 2
-
-
Zalcberg, J.1
-
100
-
-
0041831125
-
Raltitrexed-induced hepatotoxicity: Multivariate analysis of predictive factors
-
Massacesi C et al. (2003) Raltitrexed-induced hepatotoxicity: multivariate analysis of predictive factors. Anticancer Drugs 14: 533-541
-
(2003)
Anticancer Drugs
, vol.14
, pp. 533-541
-
-
Massacesi, C.1
-
101
-
-
0000291599
-
A phase I evaluation of LY231514, a novel multitargeted antifolate, administered every 21 days
-
abstract, 1559, Philadelphia, PA. Alexandria, VA: ASCO Publications
-
Rinaldi DA et al. (1996) A phase I evaluation of LY231514, a novel multitargeted antifolate, administered every 21 days [abstract # 1559]. In Proceedings of the American Society of Clinical Oncology Annual Meeting: 1996 May 18-21, Philadelphia, PA. Alexandria, VA: ASCO Publications
-
(1996)
Proceedings of the American Society of Clinical Oncology Annual Meeting: 1996 May 18-21
-
-
Rinaldi, D.A.1
-
103
-
-
0036562507
-
Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy
-
Niyikiza C et al. (2002) Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer Ther 1: 545-552
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 545-552
-
-
Niyikiza, C.1
|