Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer

Journal of Clinical Oncology

Volumn 17, Issue 5, 1999, Pages 1356-1363

  Erlichman, C ^a   O'Connell, M ^a   Kahn, M ^a   Marsoni, S ^b   Torri, V ^b   Tardio, B ^b   Zaniboni, A ^b   Pancera, G ^b   Matignoni, G ^b   Labianca, R ^b   Bami, A ^b   Seitz, J F ^c   Milan, C ^c   Bedenne, L ^c   Giovannini, M ^c,c   Letreut, Y P ^c   Skillings, J ^d   Shepard, L ^d   Zee, B ^d   Petrioli, R ^d,e   Francini, G ^d,e   Aitini, E ^a   Apolone, G ^a   Auzzani, A ^a   Banducci, S ^a   Beretta, G D ^a   Biffi, O ^a   Bucci, F ^a   Cardi, G ^a   Cifatte, D ^a   Colucci, G ^a   Comadone, A ^a   Comella, G ^a   Confalonieri, C ^a   Contu, A ^a   Costanzo, M ^a   Crespi, C ^a   Damiani, E ^a   DeGiorgi, D ^a   Dongiovanni, V ^a   Fabris, G ^a   Fabrizio, G ^a   Facendola, G ^a   Fantoni, P A ^a   Ferragni, A ^a   Fiori, B ^a   Florianello, F ^a   Frontini, L ^a   Galli, E ^a   Garattini, P ^a   Gherardi, G ^a   Giovanelli, A ^a   Giuliani, R ^a   Gosso, P ^a   Ianniello, P ^a   Kildani, B ^a   Leo, S ^a   Liberati, A ^a   Maffione, G ^a   Maiello, E ^a   Maiorino, L ^a   Manente, P ^a   Marzola, M ^a   Mastrodonato, M ^a   Meriggi, F ^a   Molinari, B ^a   Molinari, G F ^a   Monferroni, N ^a   Nascimben, O ^a   Natale, C ^a   Negretti, S ^a   Palazzo, S ^a   Panvivi, D ^a   Parisi, V ^a   Pedicini, T ^a   Peradotto, F ^a   Pessa, S ^a   Piatto, E ^a   Pizzi, G ^a   Prosperi, A ^a   Prusciano, F ^a   Rabbi, C ^a   Raina, A ^a   Ruggiero, A ^a   Sava, C ^a   Scanzi, F ^a   Setti Carraro, P ^a   Smerieri, F ^a   Stivala, B ^a   Taiana, A ^a   Testore, F ^a   Tinazzi, A ^a   Turcato, G ^a   Zonato, S ^a   Ayoub, J ^d   Bdanger, K ^d   Biron, G ^d   Bodurtha, A J ^d   Boos, G ^d   Bumdl, M ^d   Cano, P ^d   Charpentier, D ^d   Chow, W S W ^d   Chritehley, J ^d   Cripps, C ^d   Dang, S P ^d   Davis, M L ^d   Davidson, M ^d   Dingle, B ^d   Dryer, D ^d   Ferland, E ^d   Fields, A ^d   Fine, S ^d   Jolivet, J ^d   Kaiser, L ^d   Kerr, I ^d   Kocha, W I ^d   Kotwall, C ^d   Drieger, H ^d   Lepine Martin, M ^d   Little, C ^d   Lofters, W S ^d   Maheu, M ^d   Moore, M ^d   Pater, J ^d   Pressnail, B ^d   Rayner, J ^d   Reznick, R ^d   Ross, T ^d   Rotstein, L ^d   Rudinskas, L ^d   Schacter, B ^d   Shah, A ^d   Stem, H ^d   Tweedale, M ^d   Vandenberg, T ^d   Wade, D ^d   Watt, H J ^d   Wilson, K ^d   Wong, A ^d   Yoshida, S ^d   Baldit, C ^c   Baroni, J L ^c   Bazin, J P ^c   Blanchi, A ^c   Bognel, J C ^c   Bosset, J F ^c   Bouche, O ^c   Brandone, J M ^c   Bricot, R ^c   Burtin, P ^c   Cador, L ^c   Charbit, M ^c   Charlier, A ^c   Courouble, Y ^c   Couzigou, P ^c   Cuilleret, J ^c   Delpero, J R ^c   Ducreux, M ^c   Dumas, F ^c   Echinard, E ^c   Etienne, P L ^c   Friguet, J L ^c   Gignoux, M ^c   Herr, J P ^c   Lafon, J ^c   Letreut, P ^c   Latrive, J P ^c   Lauvaux, C ^c   Louvet, C ^c   MacKiewicz, R ^c   Maurel, C ^c   Messerschmitt, C ^c   Morand, L ^c   Moreau, J ^c   Morin, T ^c   Nordlinger, B ^c   Noterdaeme, P M ^c   Ollier, J C ^c   Picaud, R ^c   Pienkowski, P ^c   Plachot, J P ^c   Portet, R ^c   Rallier Du Baty, H ^c   Rougier, P ^c   Rozental, G ^c   Sastre, B ^c   Votte Lambert, A ^c   Watrin, B ^c   Zeitoun, P ^c   Mailliard, J A ^f   MacDonald, J S ^f   Haller, D G ^f   Mayer, R J ^f   Wieand, H S ^f   Lorenzini, L ^e   Mancini, S ^e   Armenio, S ^e   Tanzini, G ^e   Marsili, S ^e   Aquino, A ^e   Marzocca, G ^e   Civitelli, S ^e   Mariani, L ^e   DeSando, D ^e   Bovenga, S ^e   Lorenzi, M ^e   more..

^a MAYO CLINIC   (United States)

^b Gruppo Italiano di Valutazione Interventi in Oncologia   (Italy)

^c Fondation Française de Cancerologie Digestive   (France)

^d Institut national du cancer du Canada   (Canada)

^e UNIVERSITY OF SIENA   (Italy)

^f Cancer Control Program   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; COLON CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; FEMALE; FOLLOW UP; GASTROINTESTINAL TOXICITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MODEL; NAUSEA; OBSERVATION; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; STATISTICS; STOMATITIS; TREATMENT OUTCOME;

EID: 0032950293     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.5.1356     Document Type: Article

References (31)

1. Keyomarsi K, Moran RG: Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res 46:5229-5235, 1986
2. Rustum YM, Trave F, Zakrzewsi SF, et al: Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin. Natl Cancer Inst Monogr 5:165-170, 1987
3. Park J, Collins JM, Gazdar AF, et al: Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines. J Natl Cancer Inst 80:1560-1564, 1988
4. Erlichman C, Fine S, Wong A, et al: A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol 6:469-475, 1988
5. Poon MA, O'Connell MJ, Moertel CG, et al: Biochemical modulation of fluorouracil: Evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. J Clin Oncol 7:1407-1418, 1989
6. Doroshow JH, Bertrand M, Multhauf P, et al: Prospective randomized trial comparing 5-FU versus 5-FU and high dose folinic acid for treatment of advanced colorectal cancer. Proc Am Soc Clin Oncol 6:96a, 1987 (abstr)
7. Petrelli N, Herrera L, Rustum Y, et al: A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5:1559-1565, 1987
8. Petrelli N, Douglass HO Jr, Herrera L, et al: The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase III trial - Gastrointestinal Tumor Study Group. J Clin Oncol 7:1419-1426, 1989
9. Piedbois P, Buyse M, Rustum Y, et al: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 10:896-903, 1992
10. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer: International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators. Lancet 345:939-944, 1995
11. Francini G, Petrioli R, Lorenzini L, et al: Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology 106:899-906, 1994
12. O'Connell MJ, Mailliard JA, Kahn MJ, et al: Controlled trial of fluorouracil and low-dose leucovorin given for six months as postoperative adjuvant therapy for colon cancer. J Clin Oncol 15:246-250, 1997
13. Erlichman C, Marsoni S, Seitz JF, et al. Event free and overall survival is increased by FUFA in resected B colon cancer: A pooled analysis of five randomized trials (RCTS). Proc Am Soc Clin Oncol 16:991a, 1997 (abstr)
14. Wolmark N, Rockette H, Fisher B, et al: The benefit of leucovorin-modulated fluorouracil as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03. J Clin Oncol 11:1879-1887, 1993
15. Zee B, Pater J, Torri V, et al: Salvaging clinical trials forced to terminate early by results of external information. Control Clin Trials 15:439, 1993
16. Pater JL: Timing the collaborative analysis of three trials comparing 5FU plus folinic acid (FUFA) to surgery alone in the management of resected colorectal cancer: A National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG) perspective. Stat Med 13:1337-1340, 1993
17. Lachin JM, Foulkes MA: Evaluation of sample size and power analyses of survival with allowance for nonuniform patient entry, loss to follow-up, non-compliance and stratification. Biometrics 42:507-509, 1986
18. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
19. Cox DR: The Analysis of Binary Data. London, United Kingdom, Methuen, 1970
20. Cox DR: Regression models and life tables (with discussion). J R Stat Soc (Br) 34:187-220, 1972
21. Moertel CG, Fleming TR, Macdonald JS, et al: Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes' B2 colon cancer. J Clin Oncol 13:2936-2943, 1995
22. Wolmark N, Rockette H, Wickerham DL, et al: Adjuvant therapy of Dukes' A, B, and C adenocarcinoma of the colon with portal-vein fluorouracil hepatic infusion: Preliminary results of National Surgical Adjuvant Breast and Bowel Project protocol C-02. J Clin Oncol 8:1466-1475, 1990
23. Wolmark N, Fisher B, Rockette H, et al: Postoperative adjuvant chemotherapy or BCG for colon cancer: Results from NSABP protocol C-01. J Natl Cancer Inst 80:30-36, 1988
24. Wolmark N, Rockette H, Mamounas EP, et al: The relative efficacy of 5FU + leucovorin (FU-LV), 5FU + levamisole (FU + LEV) and 5FU + leucovorin + levamisole (FU-LV-LEV) in Dukes' B and C carcinoma of the colon: First report of NS ABP C-04. Proc Am Soc Clin Oncol. 15:205a, 1996 (abstr)
25. Mamounas EP, Rockette H, Jones J, et al: Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus C colon cancer. Proc Am Soc Clin Oncol 15:205a, 1996 (abstr)
26. Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260:816-819, 1993
27. Kojima M, Konishi F, Tsukamoto T, et al: Ki-ras point mutation in different types of colorectal carcinomas in early stages. Dis Colon Rectum 40:161-167, 1997
28. Andersen SN, Lvig T, Breivik J, et al: K-ras mutations and prognosis in large-bowel carcinomas. Scand J Gastroenterol 32-62-69, 1997
29. Carethers JM: The cellular and molecular pathogenesis of colorectal cancer. [review]. Gastroenterol Clin North Am 25:737-754, 1996
30. Zeng ZS, Huang Y, Cohen AM, et al: Prediction of colorectal cancer relapse and survival via tissue RNA levels of matrix metalloproteinase-9. J Clin Oncol 14:3133-3140, 1996
31. Shibata D, Reale MA, Lavin P, et al: The DCC protein and prognosis in colorectal cancer. N Engl J Med 335-1727-1732, 1996