Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older

Journal of Clinical Oncology

Volumn 17, Issue 8, 1999, Pages 2412-2418

  Popescu, R A ^a   Norman, A ^a   Ross, P J ^a   Parikh, B ^a   Cunningham, D ^a  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; FLUOROURACIL; FOLINIC ACID; MITOMYCIN; RALTITREXED;

ADULT; AGED; ARTICLE; BONE MARROW SUPPRESSION; CANCER ADJUVANT THERAPY; CANCER PALLIATIVE THERAPY; CANCER SURVIVAL; CLINICAL TRIAL; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; FEVER; GASTROINTESTINAL TOXICITY; HUMAN; INFECTION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; PRIORITY JOURNAL; QUALITY OF LIFE;

EID: 0032792959     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.1999.17.8.2412     Document Type: Article

References (24)

1. Furner SE, Brody JA, Jankowski LM: Epidemiology and aging, in Cassel CK, Cohen HJ, Larson EB, et al (eds): Geriatric Medicine (ed 3). New York, NY, Springer, 1997, pp 37-43
2. Miller BA, Ries LAG, Hankey BF, et al: SEER Cancer Statistics Review: 1973-1990. Bethesda, MD, National Cancer Institute, National Institutes of Health, 1993
3. Cancer Research Campaign: Cancer of the Large Bowel: UK. London, United Kingdom, Cancer Research Campaign, 1993
4. Cooper GS, Yuan Z, Landefeld CS, et al: A national population-based study of incidence of colorectal cancer and age: Implications for screening in older Americans. Cancer 75:775-781, 1995
5. Fentiman IS, Tirelli U, Monfardini S, et al: Cancer in the elderly: Why so badly treated? Lancet 335:1020-1022, 1990
6. Jessup JM, McGinnis LS, Steele GD Jr, et al: The National Cancer Data Base: Report on colon cancer. Cancer 78:918-926, 1996
7. De Rijke JM, Schouten LJ, Schouten HC, et al: Age-specific differences in the diagnostics and treatment of cancer patients aged 50 years and older in the province of Limburg, the Netherlands. Ann Oncol 7:677-685, 1996
8. Arveux I, Boutron MC, El Mrini T, et al: Colon cancer in the elderly: Evidence for major improvements in health care and survival. Br J Cancer 76:963-967, 1997
9. Fitzgerald SD, Longo WE, Daniel GL, et al: Advanced colorectal neoplasia in the high-risk elderly patient: Is surgical resection justified? Dis Colon Rectum 36:161-166, 1993
10. Irvin TT: Prognosis of colorectal cancer in the elderly. Br J Surg 75:419-421, 1988
11. Arnaud JP, Schloegel M, Ollier JC, et al: Colorectal cancer in patients over 80 years of age. Dis Colon Rectum 34:896-898, 1991
12. Whittle J, Steinberg EP, Anderson GF, et al: Results of colectomy in elderly patients with colon cancer, based on Medicare claims data [see comments]. Am J Surg 163:572-576, 1992
13. Fong Y, Kemeny N, Paty P, et al: Treatment of colorectal cancer: Hepatic metastasis. Semin Surg Oncol 12:219-252, 1996
14. Trimble EL, Carter CL, Cain D, et al: Representation of older patients in cancer treatment trials. Cancer 74:2208-2214, 1994
15. Brower M, Asbury R, Kramer Z, et al: Adjuvant chemotherapy for colorectal cancer in the elderly: Population-based experience. Proc Am Soc Clin Oncol 12:195, 1993 (abstr 570)
16. Forman WB: The role of chemotherapy and adjuvant therapy in the management of colorectal cancer. Cancer 74:2151-2153, 1994
17. O'Connell M, Maillard J, Macdonald J, et al: An intergroup trial of intensive course 5FU and low dose leucovorin as surgical adjuvant therapy for high risk colon cancer. Proc Am Soc Clin Oncol 12:190, 1993 (abstr 552)
18. National Cancer Institute: Guidelines for Reporting of Adverse Drug Reactions. Bethesda, MD, National Cancer Institute, Division of Cancer Treatment, 1988
19. Miller AB, Hoogstraaten B, Staquet M, et al: Reporting results of cancer treatment. Cancer 47:207-214, 1981
20. Stein BN, Petrelli NJ, Douglass HO, et al: Age and sex are independent predictors of 5-fluorouracil toxicity: Analysis of a large scale phase III trial. Cancer 75:11-17, 1995
21. Begg CB, Carbone PP: Clinical trials and drug toxicity in the elderly: The experience of the Eastern Cooperative Oncology Group. Cancer 52:1986-1992, 1983
22. Cascinu S, Del Ferro E, Catalano G: Toxicity and therapeutic response to chemotherapy in patients aged 70 years or older with advanced cancer. Am J Clin Oncol 19:371-374, 1996
23. Lokich JJ, Ahlgren JD, Gullo LL, et al: A prospective randomized comparison of continuous infusional fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study. J Clin Oncol 7:425-432, 1989
24. The Meta-Analysis Group in Cancer: Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 16:301-308, 1998