-
2
-
-
0026721532
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
-
Advanced Colorectal Cancer Meta-Analysis Project: Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 10:896-903, 1992
-
(1992)
J Clin Oncol
, vol.10
, pp. 896-903
-
-
-
3
-
-
0029919598
-
Irinotecan (CPT-11) is an active agent in untreated patients with metastatic colorectal cancer
-
Conti JA, Kemeny N, Saltz L, et al: Irinotecan (CPT-11) is an active agent in untreated patients with metastatic colorectal cancer. J Clin Oncol 14:709-715, 1996
-
(1996)
J Clin Oncol
, vol.14
, pp. 709-715
-
-
Conti, J.A.1
Kemeny, N.2
Saltz, L.3
-
4
-
-
9044245305
-
ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
-
Zalcberg J, Cunningham D, Van Cutsem E, et al: ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. J Clin Oncol 14:716-721, 1996
-
(1996)
J Clin Oncol
, vol.14
, pp. 716-721
-
-
Zalcberg, J.1
Cunningham, D.2
Van Cutsem, E.3
-
5
-
-
0028966253
-
A randomized trial of two schedules of trimetrexate versus 5-fluorouracil in advanced colorectal cancer: A Southwest Oncology Group study
-
Brown TD, Fleming TR, Goodman PJ, et al: A randomized trial of two schedules of trimetrexate versus 5-fluorouracil in advanced colorectal cancer: A Southwest Oncology Group study. Anticancer Drugs 6:219-223, 1995
-
(1995)
Anticancer Drugs
, vol.6
, pp. 219-223
-
-
Brown, T.D.1
Fleming, T.R.2
Goodman, P.J.3
-
6
-
-
0023912294
-
Phase 1 and 2 studies of trimetrexate administered in combination with fluorouracil to patients with metastatic cancer
-
Hudes GR, Comis RL: Phase 1 and 2 studies of trimetrexate administered in combination with fluorouracil to patients with metastatic cancer. Semin Oncol 15:41-45, 1988
-
(1988)
Semin Oncol
, vol.15
, pp. 41-45
-
-
Hudes, G.R.1
Comis, R.L.2
-
7
-
-
0028323029
-
Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma
-
Conti J, Kemeny N, Seiter K, et al: Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma. J Clin Oncol 12:695-700, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 695-700
-
-
Conti, J.1
Kemeny, N.2
Seiter, K.3
-
8
-
-
0021119743
-
Biochemical pharmacology of the lipophilic antifolate, trimetrexate
-
Jackson RC, Froy DW, Boritzki TJ, et al: Biochemical pharmacology of the lipophilic antifolate, trimetrexate. Adv Enzyme Regul 22:187-206, 1984
-
(1984)
Adv Enzyme Regul
, vol.22
, pp. 187-206
-
-
Jackson, R.C.1
Froy, D.W.2
Boritzki, T.J.3
-
9
-
-
0020035148
-
Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs
-
Weir E, Cashmore A, Dreyer R, et al: Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs. Cancer Res 42:1696-1702, 1982
-
(1982)
Cancer Res
, vol.42
, pp. 1696-1702
-
-
Weir, E.1
Cashmore, A.2
Dreyer, R.3
-
10
-
-
0023485116
-
Trimetrexate: Clinical development of a nonclassical antifolate
-
O'Dwyer P, DeLap R, King S, et al: Trimetrexate: Clinical development of a nonclassical antifolate. NCI Monogr 5:105-109, 1987
-
(1987)
NCI Monogr
, vol.5
, pp. 105-109
-
-
O'Dwyer, P.1
DeLap, R.2
King, S.3
-
11
-
-
0021340811
-
Uptake and efficacy of trimetrexate, a nonclassical antifolate in methotrexate resistant leukemia cells in vitro
-
Kamen B, Cashmore A, Dreyer R, et al: Uptake and efficacy of trimetrexate, a nonclassical antifolate in methotrexate resistant leukemia cells in vitro. Biochem Pharmacol 33:1697-1699, 1984
-
(1984)
Biochem Pharmacol
, vol.33
, pp. 1697-1699
-
-
Kamen, B.1
Cashmore, A.2
Dreyer, R.3
-
12
-
-
0025816073
-
Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties
-
Lin J, Bertino B: Update on trimetrexate, a folate antagonist with antineoplastic and antiprotozoal properties. Cancer Invest 9:159-172, 1991
-
(1991)
Cancer Invest
, vol.9
, pp. 159-172
-
-
Lin, J.1
Bertino, B.2
-
13
-
-
0023923192
-
Preclinical studies with trimetrexate: A review of conclusions and unanswered questions
-
Jackson R, Leopold W, Hamelehle K, et al: Preclinical studies with trimetrexate: A review of conclusions and unanswered questions. Semin Oncol 15:1-7, 1988 (suppl 2)
-
(1988)
Semin Oncol
, vol.15
, Issue.2 SUPPL.
, pp. 1-7
-
-
Jackson, R.1
Leopold, W.2
Hamelehle, K.3
-
14
-
-
0026642174
-
Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil in CCRF-CEM cells
-
Romanini A, Li W, Colofiore J, et al: Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil in CCRF-CEM cells. J Natl Cancer Inst 84:1033-1038, 1992
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1033-1038
-
-
Romanini, A.1
Li, W.2
Colofiore, J.3
-
15
-
-
0029012118
-
Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group study
-
Leichman CG, Fleming TR, Muggia FM, et al: Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group study. J Clin Oncol 13:1303-1311, 1995
-
(1995)
J Clin Oncol
, vol.13
, pp. 1303-1311
-
-
Leichman, C.G.1
Fleming, T.R.2
Muggia, F.M.3
-
16
-
-
0021868463
-
A phase II study of sequential methotrexate and fluorouracil in advanced colorectal cancer
-
Panasci L, Ford J, Margolese R: A phase II study of sequential methotrexate and fluorouracil in advanced colorectal cancer. Cancer Chemother Pharmacol 15:164-166, 1985
-
(1985)
Cancer Chemother Pharmacol
, vol.15
, pp. 164-166
-
-
Panasci, L.1
Ford, J.2
Margolese, R.3
-
17
-
-
0021637621
-
Sequential methotrexate and 5-fluorouracil: Improved response rate in metastatic colorectal cancer
-
Hermann R, Spehn J, Beyer JH, et al: Sequential methotrexate and 5-fluorouracil: Improved response rate in metastatic colorectal cancer. J Clin Oncol 2:591-594, 1984
-
(1984)
J Clin Oncol
, vol.2
, pp. 591-594
-
-
Hermann, R.1
Spehn, J.2
Beyer, J.H.3
-
18
-
-
0024342059
-
Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: A randomized trial of the Northern California Oncology Group
-
Valone FH, Friedman MA, Wittlinger PS, et al: Treatment of patients with advanced colorectal carcinomas with fluorouracil alone, high-dose leucovorin plus fluorouracil, or sequential methotrexate, fluorouracil, and leucovorin: A randomized trial of the Northern California Oncology Group. J Clin Oncol 7:1427-1436, 1989
-
(1989)
J Clin Oncol
, vol.7
, pp. 1427-1436
-
-
Valone, F.H.1
Friedman, M.A.2
Wittlinger, P.S.3
-
19
-
-
0023762906
-
Phase I clinical and pharmacokinetic study of trimetrexate using a daily x 5 schedule
-
Stewart JA, McCormack JJ, Tong W, et al: Phase I clinical and pharmacokinetic study of trimetrexate using a daily x 5 schedule. Cancer Res 48:5029-5035, 1988
-
(1988)
Cancer Res
, vol.48
, pp. 5029-5035
-
-
Stewart, J.A.1
McCormack, J.J.2
Tong, W.3
-
20
-
-
0024339631
-
A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: Clinical pharmacology and pharmacodynamics
-
Grochow LB, Noe DA, Ettinger DS, et al: A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: Clinical pharmacology and pharmacodynamics. Cancer Chemother Pharmacol 24:314-320, 1989
-
(1989)
Cancer Chemother Pharmacol
, vol.24
, pp. 314-320
-
-
Grochow, L.B.1
Noe, D.A.2
Ettinger, D.S.3
-
21
-
-
0024373261
-
A phase I study of trimetrexate (NSC 352122) administered by 5-day continuous intravenous infusion
-
Bishop JF, Raghavan D, Olver IN, et al: A phase I study of trimetrexate (NSC 352122) administered by 5-day continuous intravenous infusion. Cancer Chemother Pharmacol 24:246-250, 1989
-
(1989)
Cancer Chemother Pharmacol
, vol.24
, pp. 246-250
-
-
Bishop, J.F.1
Raghavan, D.2
Olver, I.N.3
-
22
-
-
0023230164
-
A phase I study of trimetrexate, an analog of methotrexate, administered monthly in the form of nine consecutive daily bolus injections
-
Jolivet J, Landry L, Pinard MF, et al: A phase I study of trimetrexate, an analog of methotrexate, administered monthly in the form of nine consecutive daily bolus injections. Cancer Chemother Pharmacol 20:169-172, 1987
-
(1987)
Cancer Chemother Pharmacol
, vol.20
, pp. 169-172
-
-
Jolivet, J.1
Landry, L.2
Pinard, M.F.3
-
23
-
-
0023151373
-
Phase I studies with trimetrexate: Clinical pharmacology, analytical methodology, and pharmacokinetics
-
Lin JT, Cashmore AR, Baker M, et al: Phase I studies with trimetrexate: Clinical pharmacology, analytical methodology, and pharmacokinetics. Cancer Res 47:609-616, 1987
-
(1987)
Cancer Res
, vol.47
, pp. 609-616
-
-
Lin, J.T.1
Cashmore, A.R.2
Baker, M.3
-
24
-
-
0023186673
-
Pharmacokinetics of trimetrexate administered by five-day continuous infusion to patients with advanced cancer
-
Reece PA, Morris RG, Bishop JF, et al: Pharmacokinetics of trimetrexate administered by five-day continuous infusion to patients with advanced cancer. Cancer Res 47:2996-2999, 1987
-
(1987)
Cancer Res
, vol.47
, pp. 2996-2999
-
-
Reece, P.A.1
Morris, R.G.2
Bishop, J.F.3
-
25
-
-
0023257541
-
Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks
-
Fanucchi MP, Walsh TD, Fleisher M, et al: Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks. Cancer Res 47:3303-3308, 1987
-
(1987)
Cancer Res
, vol.47
, pp. 3303-3308
-
-
Fanucchi, M.P.1
Walsh, T.D.2
Fleisher, M.3
-
26
-
-
0025285298
-
A phase I and pharmacokinetic study of trimetrexate using a 24-hour continuous-injection schedule
-
Allegra CJ, Jenkins J, Weiss RB, et al: A phase I and pharmacokinetic study of trimetrexate using a 24-hour continuous-injection schedule. Invest New Drugs 8:159-166, 1990
-
(1990)
Invest New Drugs
, vol.8
, pp. 159-166
-
-
Allegra, C.J.1
Jenkins, J.2
Weiss, R.B.3
-
27
-
-
0024589258
-
Phase I trial of trimetrexate glucuronate on a five-day bolus schedule: Clinical pharmacology and pharmacodynamics
-
Grochow LB, Noe DA, Dole GB, et al: Phase I trial of trimetrexate glucuronate on a five-day bolus schedule: Clinical pharmacology and pharmacodynamics. J Natl Cancer Inst 81:124-130, 1989
-
(1989)
J Natl Cancer Inst
, vol.81
, pp. 124-130
-
-
Grochow, L.B.1
Noe, D.A.2
Dole, G.B.3
-
28
-
-
0025890015
-
Phase I studies of trimetrexate using single and weekly dose schedules
-
Huan SD, Legha SS, Raber Mn, et al: Phase I studies of trimetrexate using single and weekly dose schedules. Invest New Drugs 9:199-206, 1991
-
(1991)
Invest New Drugs
, vol.9
, pp. 199-206
-
-
Huan, S.D.1
Legha, S.S.2
Raber, Mn.3
-
29
-
-
0342983699
-
Efficacy of trimetrexate (CI-898, TMTX) in patients with solid tumors
-
abstr
-
Maroun J, Leiby J, Capizzi R, et al: Efficacy of trimetrexate (CI-898, TMTX) in patients with solid tumors. Clin Res 35:529A, 1987 (abstr)
-
(1987)
Clin Res
, vol.35
-
-
Maroun, J.1
Leiby, J.2
Capizzi, R.3
-
30
-
-
0025613191
-
A phase II study of trimetrexate therapy for metastatic colorectal carcinoma
-
Ajani J, Abbruzzese J, Faintuch J, et al: A phase II study of trimetrexate therapy for metastatic colorectal carcinoma. Cancer Invest 8:619-621, 1990
-
(1990)
Cancer Invest
, vol.8
, pp. 619-621
-
-
Ajani, J.1
Abbruzzese, J.2
Faintuch, J.3
-
31
-
-
0028346901
-
Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea
-
Abigerges D, Armand J-P, Chabot GG, et al: Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. J Natl Cancer Inst 86:446-449, 1994
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 446-449
-
-
Abigerges, D.1
Armand, J.-P.2
Chabot, G.G.3
-
32
-
-
0028175144
-
Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
-
Buroker, TR, O'Connell MJ, Wieand HS, et al: Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 12:14-20, 1994
-
(1994)
J Clin Oncol
, vol.12
, pp. 14-20
-
-
Buroker, T.R.1
O'Connell, M.J.2
Wieand, H.S.3
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