Early biotransformations of oxaliplatin after its intravenous administration to cancer patients

Drug Metabolism and Disposition

Volumn 28, Issue 11, 2000, Pages 1379-1384

  Allain, Pierre ^a   Heudi, Oliver ^a   Cailleux, Annie ^a   Le Bouil, Anne ^a   Larra, Francis ^b   Boisdron Celle, Michele ^b   Gamelin, Erik ^b  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b CENTRE PAUL PAPIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; HEMOGLOBIN; IMMUNOGLOBULIN; OXALIPLATIN;

ADULT; AGED; ARTICLE; CANCER PATIENT; CASE REPORT; DRUG DEGRADATION; DRUG PENETRATION; DRUG TRANSFORMATION; ERYTHROCYTE; HUMAN; MASS SPECTROMETRY; PLASMA PROTEIN BINDING; PRIORITY JOURNAL;

AGED; ANTINEOPLASTIC AGENTS; BIOTRANSFORMATION; BLOOD PROTEINS; CHROMATOGRAPHY, LIQUID; HUMANS; INFUSIONS, INTRAVENOUS; MASS SPECTROMETRY; MIDDLE AGED; NEOPLASMS; ORGANOPLATINUM COMPOUNDS;

EID: 0033790788     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

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2. Report on the pharmacokinetics of oxaliplatin in patients with normal and impaired renal function
3. Pharmacokinetics of non protein-bound platinum species following administration of cisdichlorodiammineplatinum(II)
4. Application of liquid chromatography inductively coupled plasma mass spectrometry to the study of protein-bound lead in haman erythrocytes
5. Clinical pharmacokinetics and dose optimisation of carboplatin
6. Determination of unbound platinum after oxaliplatin administration: Comparison of currently available methods and influence of various parameters
7. Cumulative pharmacokinetic study of oxaliplatin, administrated every three weeks, combined with 5-fluorouracil in colorectal cancer patients
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9. Biotransformations of oxaliplatin in rat blood in vitro
10. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin
11. Passive transport and binding of lead by human red blood cells
12. In vitro binding of oxaliplatin to human serum proteins