FK1706, a novel non-immunosuppressant neurophilin ligand, ameliorates motor dysfunction following spinal cord injury through its neuroregenerative action

European Journal of Pharmacology

Volumn 591, Issue 1-3, 2008, Pages 147-152

  Yamaji, Takayuki ^a   Yamazaki, Shunji ^a   Li, Jiyao ^a   Price, Raymond D ^a   Matsuoka, Nobuya ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

FK506 binding protein; Immunophilin; Nerve growth factor; Neurite outgrowth; Neurofilament; Neurotrophic

Indexed keywords

1,14 DIHYDROXY 12 [2 (4 HYDROXY 3 METHOXYCYCLOHEXYL) 1 METHYLVINYL] 23,25 DIMETHOXY 13,19,21,27 TETRAMETHYL 17 (2 OXOPROPYL) 11,28 DIOXA 4 AZATRICYCLO[22.3.1.0 4.9]OCTACOS 18 ENE 2,3,10,16 TETRONE; DRUG VEHICLE; FK 1706; LIGAND; NERVE GROWTH FACTOR; NEUROPHILIN LIGAND; NEUROPROTECTIVE AGENT; NEUROTROPHIC FACTOR; NEUROTROPHIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL REGENERATION; CONTROLLED STUDY; CONTUSION; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE FIBER REGENERATION; NERVE GROWTH; NEUROPHARMACOLOGY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION;

ANIMALS; AXONS; DISEASE MODELS, ANIMAL; IMMUNOPHILINS; MALE; NERVE GROWTH FACTOR; NERVE REGENERATION; NEUROPROTECTIVE AGENTS; PYRAMIDAL TRACTS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TACROLIMUS; TIME FACTORS;

EID: 48749091532     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.064     Document Type: Article

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