-
1
-
-
0000179727
-
Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
-
Ames, B. N. 1973. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. USA 70:2281-2285.
-
(1973)
Proc. Natl. Acad. Sci. USA
, vol.70
, pp. 2281-2285
-
-
Ames, B.N.1
-
2
-
-
0025287177
-
Proliferative and genotoxic cellular effects in 2-acetylamino-fluorene bladder and liver carcinogenesis: Biological modeling of the EDO1 study
-
Cohen, S. M., and Ellwein, L. B. 1990. Proliferative and genotoxic cellular effects in 2-acetylamino-fluorene bladder and liver carcinogenesis: Biological modeling of the EDO1 study. Toxicol. Appl. Pharmacol. 104:79-93.
-
(1990)
Toxicol. Appl. Pharmacol.
, vol.104
, pp. 79-93
-
-
Cohen, S.M.1
Ellwein, L.B.2
-
3
-
-
0029008910
-
Effects of low doses of N-nitrosomorpholine on the development of early stages of hepatocarcinogenesis
-
Enzmann, H., Zerban, H., Kopp-Schneider, A., Löser, A., and Bannasch, P. 1995. Effects of low doses of N-nitrosomorpholine on the development of early stages of hepatocarcinogenesis. Carcinogenesis 16:1513-1418.
-
(1995)
Carcinogenesis
, vol.16
, pp. 1513-11418
-
-
Enzmann, H.1
Zerban, H.2
Kopp-Schneider, A.3
Löser, A.4
Bannasch, P.5
-
4
-
-
0027298428
-
The fifth plot of the carcinogenic potency database: Results of animal bioassays published in the general literature through 1988, by the National Toxicology Program through 1989
-
Gold, L. S., Manley, N., Slone, T., Garfinkel, G., Rohrback, L., and Ames, B. N. 1993. The fifth plot of the carcinogenic potency database: Results of animal bioassays published in the general literature through 1988, by the National Toxicology Program through 1989. Environ. Health Perspect. 100:65-135.
-
(1993)
Environ. Health Perspect.
, vol.100
, pp. 65-135
-
-
Gold, L.S.1
Manley, N.2
Slone, T.3
Garfinkel, G.4
Rohrback, L.5
Ames, B.N.6
-
5
-
-
0028125906
-
A rational approach to risk assessment requires the use of biological information: An analysis of the National Toxicology Program (NTP) final report of the advisory review by the NTP Board of Scientific Counselors
-
Goodman, J. I. 1994. A rational approach to risk assessment requires the use of biological information: An analysis of the National Toxicology Program (NTP) final report of the advisory review by the NTP Board of Scientific Counselors. Regul. Toxicol. Pharmacol. 19:51-59.
-
(1994)
Regul. Toxicol. Pharmacol.
, vol.19
, pp. 51-59
-
-
Goodman, J.I.1
-
6
-
-
0019870862
-
Existence of a practical threshold dose for the hepatocarcinogen 3′-methyl-4-(dimethylamino)azobenzene in rat liver
-
Hino, O., and Kitagawa, T. 1981. Existence of a practical threshold dose for the hepatocarcinogen 3′-methyl-4-(dimethylamino)azobenzene in rat liver. Gann 72:637-638.
-
(1981)
Gann
, vol.72
, pp. 637-638
-
-
Hino, O.1
Kitagawa, T.2
-
7
-
-
26144450430
-
-
Lyon, France: IARC
-
International Agency for Research in Cancer. 1982. IARC Monogr. Eval. Carcinogen. Risk Chem. Man, Vol. 1-29, Suppl. 4, p. 13. Lyon, France: IARC.
-
(1982)
IARC Monogr. Eval. Carcinogen. Risk Chem. Man
, vol.1-29
, Issue.SUPPL. 4
, pp. 13
-
-
-
8
-
-
85045129793
-
The use of mechanistic data in the risk assessment of ten chemicals
-
International Expert Panel on Carcinogen Risk Assessment. 1996. The use of mechanistic data in the risk assessment of ten chemicals. Pharmacol. Ther. 71 (Special Issue):1-5.
-
(1996)
Pharmacol. Ther.
, vol.71
, Issue.SPECIAL ISSUE
, pp. 1-5
-
-
-
9
-
-
0018577895
-
Milestones in chemical carcinogenesis
-
Miller, E. C., and Miller, J. A. 1979. Milestones in chemical carcinogenesis. Sem. Oncol. 6:445-460.
-
(1979)
Sem. Oncol.
, vol.6
, pp. 445-460
-
-
Miller, E.C.1
Miller, J.A.2
-
10
-
-
26844458434
-
Implementation of EPA revised cancer assessment guidelines: Incorporation of mechanistic and pharmacokinetic data
-
Page, N. P., Singh, D. V., Farland, W., Goodman, J. I., Conolly, R. B., Anderson, M. E., Clewell, H. J., Frederick, C. B., Yamasaki, H., and Lucier, G. 1997. Implementation of EPA revised cancer assessment guidelines: Incorporation of mechanistic and pharmacokinetic data. Fundam. Appl. Toxicol. 37:16-36.
-
(1997)
Fundam. Appl. Toxicol.
, vol.37
, pp. 16-36
-
-
Page, N.P.1
Singh, D.V.2
Farland, W.3
Goodman, J.I.4
Conolly, R.B.5
Anderson, M.E.6
Clewell, H.J.7
Frederick, C.B.8
Yamasaki, H.9
Lucier, G.10
-
11
-
-
0028030221
-
DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents
-
Poirier, M. C., and Beland, F. A. 1994. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents. Environ. Health Perspect. 102:161-165.
-
(1994)
Environ. Health Perspect.
, vol.102
, pp. 161-165
-
-
Poirier, M.C.1
Beland, F.A.2
-
12
-
-
0003839402
-
-
Washington, DC: US Government Printing Office
-
Presidential/Congressional Commission on Risk Assessment and Risk Management. 1997. Risk assessment and risk management in regulatory decision-making, Vol. 2. Washington, DC: US Government Printing Office.
-
(1997)
Risk Assessment and Risk Management in Regulatory Decision-making
, vol.2
-
-
-
13
-
-
0030776986
-
Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver
-
Root, M., Lange, T., and Campbell, T. C. 1997. Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver. Chem. Biol. Interact. 106:213-227.
-
(1997)
Chem. Biol. Interact.
, vol.106
, pp. 213-227
-
-
Root, M.1
Lange, T.2
Campbell, T.C.3
-
14
-
-
0027422198
-
Dose response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver
-
Umemura, T., Tokumo, K., Gebhardt, R., Poirier, M., and Williams, G. M. 1993. Dose response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver. Cancer Lett. 73:1-10.
-
(1993)
Cancer Lett.
, vol.73
, pp. 1-10
-
-
Umemura, T.1
Tokumo, K.2
Gebhardt, R.3
Poirier, M.4
Williams, G.M.5
-
15
-
-
0019792758
-
Carcinogen testing: Current problems and new approaches
-
Weisburger, J. H., and Williams, G. M. 1981. Carcinogen testing: Current problems and new approaches. Science 214:401-407.
-
(1981)
Science
, vol.214
, pp. 401-407
-
-
Weisburger, J.H.1
Williams, G.M.2
-
16
-
-
0020643394
-
The distinct health risk analyses required for genotoxic carcinogens and promoting agents
-
Weisburger, J. H., and Williams, G. M. 1983. The distinct health risk analyses required for genotoxic carcinogens and promoting agents. Environ. Health Perspect. 50:233-245.
-
(1983)
Environ. Health Perspect.
, vol.50
, pp. 233-245
-
-
Weisburger, J.H.1
Williams, G.M.2
-
17
-
-
0026598008
-
International cancer risk assessment: The impact of biologic mechanisms
-
Whysner, J., and Williams, G. M. 1992. International cancer risk assessment: The impact of biologic mechanisms. Reg. Toxicol. Pharmacol. 15:41-50.
-
(1992)
Reg. Toxicol. Pharmacol.
, vol.15
, pp. 41-50
-
-
Whysner, J.1
Williams, G.M.2
-
18
-
-
0029762765
-
Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion
-
Whysner, J., Ross, P. M., and Williams, G. M. 1996. Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion. Pharm. Ther. 71:153-192.
-
(1996)
Pharm. Ther.
, vol.71
, pp. 153-192
-
-
Whysner, J.1
Ross, P.M.2
Williams, G.M.3
-
19
-
-
0004192590
-
Definition of a human cancer hazard
-
Nongenotoxic mechanisms in carcinogenesis, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory
-
Williams, G. M. 1987. Definition of a human cancer hazard. In Nongenotoxic mechanisms in carcinogenesis, pp. 367-380. Banbury Report 25. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
-
(1987)
Banbury Report
, vol.25
, pp. 367-380
-
-
Williams, G.M.1
-
20
-
-
0002509544
-
Chemical carcinogens
-
eds. C. D. Klaassen, M. O. Amdur, and J. Doull, New York: Macmillan
-
Williams, G. M., and Weisburger, J. H. 1986. Chemical carcinogens. In Casarett and Doull's toxicology: The basic sciences of poison, 3rd Ed., eds. C. D. Klaassen, M. O. Amdur, and J. Doull, pp. 99-173. New York: Macmillan.
-
(1986)
Casarett and Doull's Toxicology: The Basic Sciences of Poison, 3rd Ed.
, pp. 99-173
-
-
Williams, G.M.1
Weisburger, J.H.2
-
21
-
-
0029873622
-
Epigenetic carcinogens: Evaluation and risk assessment
-
Williams, G. M., and Whysner, J. 1996. Epigenetic carcinogens: Evaluation and risk assessment. Exp. Toxicol. Pathol. 48:189-195.
-
(1996)
Exp. Toxicol. Pathol.
, vol.48
, pp. 189-195
-
-
Williams, G.M.1
Whysner, J.2
-
22
-
-
0027439099
-
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine
-
Williams, G. M., Gebhardt, R., Shirma, H., and Stenbäck, F. 1993. Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine. Carcinogenesis 14:2149-2156.
-
(1993)
Carcinogenesis
, vol.14
, pp. 2149-2156
-
-
Williams, G.M.1
Gebhardt, R.2
Shirma, H.3
Stenbäck, F.4
-
23
-
-
0029983563
-
Chemical carcinogen mechanisms of action and implications for testing methodology
-
Williams, G. M., Iatropoulos, M. J., and Weisburger, J. H. 1996a. Chemical carcinogen mechanisms of action and implications for testing methodology. Exp. Toxicol. Pathol. 48:101-111.
-
(1996)
Exp. Toxicol. Pathol.
, vol.48
, pp. 101-111
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Weisburger, J.H.3
-
24
-
-
0029805480
-
Diethylnitrosamine exposure-responses for DNA damage, centrilobular, cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit nonlinearities
-
Williams, G. M., Iatropoulos, M. J., Wang, C. X., Rivenson, A., Peterson, L. A., Schulz, C., and Gebhardt, R. 1996b. Diethylnitrosamine exposure-responses for DNA damage, centrilobular, cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit nonlinearities. Carcinogenesis 17:2253-2258.
-
(1996)
Carcinogenesis
, vol.17
, pp. 2253-2258
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Wang, C.X.3
Rivenson, A.4
Peterson, L.A.5
Schulz, C.6
Gebhardt, R.7
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