Concordance of thresholds for carcinogenicity of N-nitrosodiethylamine

Archives of Toxicology

Volumn 80, Issue 6, 2006, Pages 305-309

  Waddell, William J ^a,d   Fukushima, Shoji ^b   Williams, Gary M ^c  

^a University of Louisville School of Medicine   (United States)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d NONE   (United States)

Author keywords

Carcinogenicity; DNA adducts; GST p+; N nitrosodiethylamine; NDEA; Thresholds

Indexed keywords

CARCINOGEN; DIETHYLNITROSAMINE; DNA; GLUTATHIONE TRANSFERASE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; DNA ADDUCT; DOSE RESPONSE; LIVER CARCINOGENESIS; LIVER TUMOR; NONHUMAN; PRIORITY JOURNAL; RAT; THERMODYNAMICS;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DIETHYLNITROSAMINE; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE TRANSFERASE; LIVER; LIVER NEOPLASMS; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; RATS, WISTAR;

RATTUS NORVEGICUS;

EID: 33646540449     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0048-y     Document Type: Article

References (23)

1. Bartsch H, Montesano R (1984) Commentary; relevance of nitrosamines to human cancer. Carcinogenesis 5:1381-1393
2. Fukushima S, Wanibuchi H, Morimura K, Wei M, Nakae D, Konishi Y, Tsuda H, Uehara N, Imaida K, Shirai T, Tatematsu M, Tsukamoto T, Hirose M, Furukawa F, Wakabayashi K, Totsuka Y (2002) Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine. Jpn J Cancer Res 93:1076-1082
3. Gold LS, Slone TH, Ames BN, Manley NB (2001) Pesticide residues in food and cancer risk: a critical analysis. In: Krieger R (eds) Handbook of pesticide toxicology, 2nd edn. Academic, San Diego pp 799-843
4. Hill AV (1913) The combinations of haemoglobin with oxygen and with carbon monoxide. Biochem J 7:471
5. Lijinsky W (1993) Life-span and cancer: the induction time of tumors in diverse animal species treated with N-nitrosodiethylamine. Carcinogenesis 14:2373-2375
6. Peto R, Gray R, Brantom P, Grasso P (1991) Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study. Cancer Res 51:6415-6451
7. Rozman KK (2003) Letter to the editor. Tox Sci 75:224-225
8. Rozman KK, Kerecsen L, Viluksela MK, Österle D, Deml E, Viluksela M, Stahl BU, Greim H, Doull J (1996) A toxicologist's view of cancer risk assessment. Drug Metab Rev 28:29-52
9. Rozman KK, Roth WL, Doull J (2005) Influences of dynamics, kinetics and exposure on toxicity in the lung. In: Gardner D (eds) Toxicology of the Lung. Taylor and Francis, Philadelphia pp 195-229
10. Spiegelhalder D, Preussmann R (1983) Occupational nitrosamine exposure. 1. Rubber and tyre industry. Carcinogenesis 4:1147-1152
11. Verna L, Whysner J, Williams GM (1996) N-Nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Therapeutics 71:57-82
12. Waddell WJ, Bates RG (1969) Intracellular pH. Physiol Rev 49:285-329
13. Waddell WJ (2002) Thresholds of carcinogenicity of flavors. Tox Sci 68:275-279
14. Waddell WJ (2003a) Threshold of carcinogenicity of N-nitrosodiethylamine for esophageal tumors in rats. Food Chem Tox 41:739-41
15. Waddell WJ (2003b) Thresholds of carcinogenicity in the ED01 study. Tox Sci 72:158-63
16. Waddell WJ (2003c) Thresholds in chemical carcinogenesis: what are animal experiments telling us. Toxicol Pathol 31:260-62
17. Waddell WJ (2003d) Comparison of human exposures to selected chemicals with thresholds from NTP carcinogenicity studies in rodents. Hum Exp Toxicol 22:501-6
18. Waddell WJ (2004) Dose-response curves in chemical carcinogenesis. Nonlinea Biol, Toxicol Med 2:11-20
19. Waddell WJ (2005) Comparisons of thresholds for carcinogenicity on linear and logarithmic dosage scales. Hum Exp Toxicol 24:325-332
20. Waddell WJ, Crooks NH, Carmichael PL (2004) Correlation of tumors with DNA adducts from methyl eugenol and tamoxifen in rats. Tox Sci 79:38-40
21. Williams GM, Iatropoulos MJ, Wang CX, Jeffrey AM, Thompson S, Pittman B, Palasch M, Gebhardt R (1998) Non-linearities in 2-acetylaminofluorene exposure-responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver. Tox Sci 45:152-161
22. Williams GM, Iatropoulos MJ, Jeffrey AM, Lou F-Q, Wang C-X, Pittman B (1999) Diethylnitrosamine exposure-responses for DNA ethylation, hepatocellular proliferation, and initiation of carcinogenesis in rat liver display non-linearities and thresholds. Arch Toxicol 73:394-402
23. Williams GM, Iatropoulos MJ, Jeffrey AM (2000) Mechanistic basis for nonlinearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine. Toxicol Pathol 28:388-395