Risk assessment of DNA-reactive carcinogens in food

Toxicology and Applied Pharmacology

Volumn 207, Issue 2 SUPPL., 2005, Pages 628-635

  Jeffrey, A M ^a   Williams, G M ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Carcinogens; DNA reactants; Food; Risk assessment

Indexed keywords

ACRYLAMIDE; AFLATOXIN B1; ARISTOLOCHIC ACID; CARCINOGEN; DNA; HEMOGLOBIN; HETEROCYCLIC AMINE; HYDRAZINE DERIVATIVE; PYRROLIZIDINE;

CARCINOGENESIS; CONFERENCE PAPER; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; FLUORESCENCE ANALYSIS; FOOD; FOOD CONTAMINATION; FOOD SAFETY; GENE MUTATION; HUMAN; IMMUNOLOGICAL PROCEDURES; MASS SPECTROMETRY; NONHUMAN; RISK ASSESSMENT; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 24644476629     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.03.024     Document Type: Conference Paper

References (71)

1. H.C. Anderson, J. Hajslova, V. Schulzova, Z. Panovska, L. Hajkova, and J. Gry Agaritine content in processed foods containing the cultivated mushroom (Agaricus bisporus) on the Nordic and the Czech market Food Addit. Contam. 16 1999 439 446
2. R.J. Bever Jr., L.H. Couch, J.B. Sutherland, A.J. Williams, R.D. Beger, M.I. Churchwell, D.R. Doerge, and P.C. Howard DNA adduct formation by Fusarium culture extracts: lack of role of fusarin C Chem. Biol. Interact. 128 2000 141 157
3. P.C. Burcham Genotoxic lipid peroxidation products: their DNA damaging properties and role in formation of endogenous DNA adducts Mutagenesis 13 1998 287 305
4. M. Careri, F. Bianchi, and C. Corradini Recent advances in the application of mass spectrometry in food-related analysis J. Chromatogr., A 970 2002 3 64
5. A.K. Chaudhary, M. Nokubo, G.R. Reddy, S.N. Yeola, J.D. Morrow, I.A. Blair, and L.J. Marnett Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver Science 265 1994 1580 1582
6. S.J. Cheng, Y.Z. Jiang, M.H. Li, and H.Z. Lo A mutagenic metabolite produced by Fusarium moniliforme isolated from Linxian county China Carcinogenesis 6 1985 903 905
7. F.L. Chung, R.G. Nath, J. Ocando, A. Nishikawa, and L. Zhang Deoxyguanosine adducts of t-4-hydroxy-2-nonenal are endogenous DNA lesions in rodents and humans: detection and potential sources Cancer Res. 60 2000 1507 1511
8. 1H NMR study FEBS Lett. 355 1994 81 90
9. J.W. Cook, I. Hieger, E.L. Kennaway, and W.V. Mayneord The production of cancer by pure hydrocarbons-Part I Proc. R. Soc. London (Biol) 111 1932 455 484
10. P. Daudel, M. Duquesne, P. Vigny, P.L. Grover, and P. Sims Fluorescence spectral evidence that benzo(a)pyrene-DNA products in mouse skin arise from diol-epoxides FEBS Lett. 57 1975 250 253
11. U. Dittberner, B. Schmetzer, P. Golzer, G. Eisenbrand, and H. Zankl Genotoxic effects of 2-trans-hexenal in human buccal mucosa cells in vivo Mutat. Res. 390 1997 161 165
12. 2-propanodeoxyguanosine adducts of 2-hexenal in vivo Arch. Toxicol. 74 2000 642 648
13. L. Ehrenberg, K.D. Hiesche, S. Osterman-Golkar, and I. Wenneberg Evaluation of genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide Mutat. Res. 24 1974 83 103
14. H. Enzmann, H. Zerban, A. Kopp-Schneider, E. Loser, and P. Bannach Effects of low doses of N-nitrosomorpholine on the development of early stages of hepatocarcinogenesis Carcinogenesis 16 1995 1513 1518
15. H. Esterbauer Cytotoxicity and genotoxicity of lipid-oxidation products Am. J. Clin. Nutr. 57 1993 779S 785S
16. H. Esterbauer, R.J. Schaur, and H. Zollner Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes Free Radical Biol. Med. 11 1991 81 128
17. J.L. Fang, C.E. Vaca, L.M. Valsta, and M. Mutanen Determination of DNA adducts of malonaldehyde in humans: effects of dietary fatty acid composition Carcinogenesis 17 1996 1035 1040
18. FDA FDA action plan for acrylamide in food 2004 (http://www.cfsan.fda. gov/~dms/acrypla3.html )
19. 32P-postlabelling in target and non-target organs of rats treated with aristolochic acid I IARC Sci. Publ. 1993 167 171
20. E.N. Frankel Hydroperoxidation of unsaturated fatty esters Basic Life Sci. 49 1988 265 282
21. P.P. Fu, Y.-C. Yang, Q. Xia, M.W. Chou, Y.Y. Cui, and G. Lin Pyrrolizidine alkaloids-tumorigenic components in Chinese herbal medicines and dietary supplements J. Food Drug Anal. 10 2004 198 211
22. S. Fukushima Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment Cancer Lett. 143 1999 157 159
23. S. Fukushima, H. Wanibuchi, K. Morimura, M. Wei, D. Nakae, Y. Konishi, H. Tsuda, N. Uehara, K. Imaida, T. Shirai, M. Tatematsu, T. Tsukamoto, M. Hirose, F. Furukawa, K. Wakabayashi, and Y. Totsuka Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine Jpn. J. Cancer Res. 93 2002 1076 1082
24. W.C. Gelderblom, N.P. Kriek, W.F. Marasas, and P.G. Thiel Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats Carcinogenesis 12 1991 1247 1251
25. J.D. Groopman, and T.W. Kensler The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight? Carcinogenesis 20 1999 1 11
26. M. Hara, T. Hanaoka, M. Kobayashi, T. Otani, H.Y. Adachi, A. Montani, S. Natsukawa, K. Shaura, Y. Koizumi, Y. Kasuga, T. Matsuzawa, T. Ikekawa, S. Sasaki, and S. Tsugane Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan Nutr. Cancer 46 2003 138 147
27. C.C. Harris, K. Vahakangas, M.J. Newman, G.E. Trivers, A. Shamsuddin, N. Sinopoli, D.L. Mann, and W.E. Wright Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers Proc. Natl. Acad. Sci. U.S.A. 82 1985 6672 6676
28. K. Hemminki, H. Autrup, and A. Haugen DNA and protein adducts Toxicology 101 1995 41 53
29. J.G. Hengstler, M.S. Bogdanffy, H.M. Bolt, and F. Oesch Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate Annu. Rev. Pharmacol. Toxicol. 43 2003 485 520
30. O. Hino, and T. Kitagawa Existence of a practical threshold dose for the hepatocarcinogen 3′-methyl-4-(dimethyl-amino) azobenzene in rat liver Gann 72 1981 637 638
31. International Agency for Research on Cancer Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins, Aflatoxins IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 1993 IARC Lyon 245 395
32. International Agency for Research on Cancer. Overall Evaluations of Carcinogenicity to Humans. Group 2B: Possibly carcinogenic to Humans, 2000. IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans (http://193.51.164.11/monoeval/crthgr02b.html).
33. C. Isaacson The change of the staple diet of black South Africans from sorghum to maize (corn) is the cause of the epidemic of squamous carcinoma of the oesophagus Med. Hypotheses 64 2005 658 660
34. R. Jankowiak, R.S. Cooper, D. Zamzow, G.J. Small, G. Doskocil, and A.M. Jeffrey Fluorescence line narrowing-nonphotochemical hole burning spectrometry: femtomole detection and high selectivity for intact DNA-PAH adducts Chem. Res. Toxicol. 1 1988 60 68
35. JECFA, 2005. http://www.who.int/ipcs/food/jecfa/summaries/en/ summary_report_64_final.pdf.
36. E.L. Kennaway, and I. Hieger Carcinogenic substances and their fluorescence spectra Br. Med. J. 1930 1044 1046
37. R. Kroes, A.G. Renwick, M. Cheeseman, J. Kleiner, I. Mangelsdorf, A. Piersma, B. Schilter, J. Schlatter, F. van Schothorst, J.G. Vos, and G. Wurtzen Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet Food Chem. Toxicol. 42 2004 65 83
38. T.Y. Liu, Y.T. Chung, P.F. Wang, C.W. Chi, and L.L. Hsieh Safrole-DNA adducts in human peripheral blood-An association with areca quid chewing and CYP2E1 polymorphisms Mutat. Res. 559 2004 59 66
39. S.J. Lu, Z.A. Ronai, M.H. Li, and A.M. Jeffrey Fusarium moniliforme metabolites: genotoxicity of culture extracts Carcinogenesis 9 1988 1523 1527
40. A. Maekawa, H. Onodera, Y. Matsushima, T. Nagaoka, A. Todate, M. Shibutani, Y. Kodama, and Y. Hayashi Dose-response carcinogenicity in rats on low-dose levels of N-ethyl-N-nitrosourethane Jpn. J. Cancer Res. 80 1989 632 636
41. W.F. Marasas, N.P. Kriek, J.E. Fincham, and S.J. van Rensburg Primary liver cancer and oesophageal basal cell hyperplasia in rats caused by Fusarium moniliforme Int. J. Cancer 34 1984 383 387
42. W.F. Marasas, K. Jaskiewicz, F.S. Venter, and D.J. Van Schalkwyk Fusarium moniliforme contamination of maize in oesophageal cancer areas in Transkei S. Afr. Med. J. 74 1988 110 114
43. L.J. Marnett Oxyradicals and DNA damage Carcinogenesis 21 2000 361 370
44. U. Mengs On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid Arch. Toxicol. 52 1983 209 220
45. U. Mengs Tumour induction in mice following exposure to aristolochic acid Arch. Toxicol. 61 1988 504 505
46. National Academies, 1996. Carcinogens and Anticarcinogens in the Human Diet: A Comparison of Naturally Occurring and Synthetic Substances (http://books.nap.edu/books/0309053919/html/359.html).
47. P.M. Newberne, G.N. Wogan, W.W. Carlton, and M.M. Abdelkader Histopathologic lesions in ducklings caused by Aspergillus flavus cultures, culture extracts, and crystalline aflatoxins Toxicol. Appl. Pharmacol. 83 1964 542 556
48. D. Palli, P. Vineis, A. Russo, F. Berrino, V. Krogh, G. Masala, A. Munnia, S. Panico, E. Taioli, R. Tumino, S. Garte, and M. Peluso Diet, metabolic polymorphisms and DNA adducts: the EPIC-Italy cross-sectional study Int. J. Cancer 87 2000 444 451
49. 6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine Biochem. J. 173 1978 739 748
50. L.H. Pottenger, M. Penman, N.P. Moore, R.A. Priston, and M. Thomas Biological significance of DNA adducts: summary of discussion of expert panel Regul. Toxicol. Pharmacol. 39 2004 403 408
51. 32P-Postlabelling methods for DNA adduct detection: overview and critical evaluation Drug Metab. Rev. 26 1994 67 85
52. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes: I. Adult female CD-1 mice Carcinogenesis 5 1984 1613 1622
53. K. Randerath, K.L. Putman, and E. Randerath Flavor constituents in cola drinks induce hepatic DNA adducts in adult and fetal mice Biochem. Biophys. Res. Commun. 192 1993 61 68
54. M. Root, T. Lange, and T.C. Campbell Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver Chem.-Biol. Interact. 106 1997 213 227
55. R.M. Santella Immunological methods for detection of carcinogen-DNA damage in humans Cancer Epidemiol., Biomarkers Prev. 8 1999 733 739
56. A. Sevanian, and P. Hochstein Mechanisms and consequences of lipid peroxidation in biological systems Annu. Rev. Nutr. 5 1985 365 390
57. G. Spiteller Linoleic acid peroxidation-The dominant lipid peroxidation process in low density lipoprotein-And its relationship to chronic diseases Chem. Phys. Lipids 95 1998 105 162
58. T. Sugimura Overview of carcinogenic heterocyclic amines Mutat. Res. 376 1997 211 219
59. A.M. Tritscher Human health risk assessment of processing-related compounds in food Toxicol. Lett. 149 2004 177 186
60. H. Tsuda, S. Fukushima, H. Wanibuchi, K. Morimura, D. Nakae, K. Imaida, M. Tatematsu, M. Hirose, K. Wakabayashi, and M.A. Moore Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work Toxicol. Pathol. 31 2003 80 86
61. U.S. Food and Drug Administration. Action Levels for Poisonous or Deleterious Substances in Human Food and Animal Feed, 2002 (http://www.cfsan. fda.gov/∼lrd/fdaact.html#afla).
62. U. Vogel, B. Danesvar, H. Autrup, L. Risom, A. Weimann, H.E. Poulsen, P. Moller, S. Loft, H. Wallin, and L.O. Dragsted Effect of increased intake of dietary animal fat and fat energy on oxidative damage, mutation frequency, DNA adduct level and DNA repair in rat colon and liver Free Radical Res. 37 2003 947 956
63. S.V. Vulimiri, G.D. Zhou, K. Randerath, and E. Randerath High levels of endogenous DNA adducts (I-compounds) in pig liver. Modulation by high cholesterol/high fat diet Mutat. Res. 422 1998 297 311
64. M. Wang, K. Dhingra, W.N. Hittelman, J.G. Liehr, M. de Andrade, and D. Li Lipid peroxidation-induced putative malondialdehyde-DNA adducts in human breast tissues Cancer Epidemiol., Biomarkers Prev. 5 1996 705 710
65. G.M. Williams, M.J. Iatropoulos, C.X. Wang, A.M. Jeffrey, S. Thompson, B. Pitmann, M. Palasch, and R. Gebhardt Non-linearities in 2-acetylaminofluorene exposure-responses for genotoxic and epigenetic effects leading to initiation of carcinogenesis in rat liver Toxicol. Sci. 45 1998 152 161
66. G.M. Williams, M.J. Iatropoulos, A.M. Jeffrey, F.Q. Luo, C.X. Wang, S. Thompson, and B. Pittman Diethylnitrosamine exposure-responses for DNA ethylation, hepatocellular proliferation and initiation of carcinogenesis in the rat liver display non-linearities and thresholds Arch. Toxicol. 73 1999 394 402
67. G.M. Williams, M.J. Iatropoulos, and A.M. Jeffrey Mechanistic basis for nonlinearities and thresholds in rat liver carcinogenesis by the DNA-reactive carcinogens 2-acetylaminofluorene and diethylnitrosamine Toxicol. Pathol. 28 2000 388 395
68. G.M. Williams, M.J. Iatropoulos, and A.M. Jeffrey Thresholds for the effects of 2-acetylaminofluorene in rat liver Toxicol. Pathol. 32 Suppl. 2 2004 85 91
69. G.M. Williams, M.J. Iatropoulos, and A.M. Jeffrey Thresholds for DNA-Reactive (Genotoxic) Organic Carcinogens J. Environ. Pathol. Toxicol. 18 2005 (in press)
70. G. Zhou, N.S. Hernandez, E. Randerath, and K. Randerath Effects of different diets and dietary restriction on perinatal endogenous DNA adducts. Time dependence of oxidative and presumptive nonoxidative lesions Mutat. Res. 447 2000 137 147
71. J. Zhu, P. Chang, M.L. Bondy, A.A. Sahin, S.E. Singletary, S. Takahashi, T. Shirai, and D. Li Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine-DNA adducts in normal breast tissues and risk of breast cancer Cancer Epidemiol., Biomarkers Prev. 12 2003 830 837