The use of mechanistic data in the risk assessments of ten chemicals: An introduction to the chemical-specific reviews

Pharmacology and Therapeutics

Volumn 71, Issue 1-2, 1996, Pages 1-5

  Ames, B N ^a   Boyle, P ^a   Douli, J ^a   Galli, C L ^a   Greim, H ^a   Hayashi, Y ^a   Hill, R N ^a   Kimbrough, R D ^a   Krewski, D ^a   Kroes, R ^a   Monson, R R ^a   Munro, I C ^a   Rajewsky, M F ^a   Scheuplein, R J ^a   Sugimura, T ^a   Swenberg, J A ^a   Travis, C C ^a   Whysner, J ^a   Williams, G M ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

Author keywords

cancer mechanism; DNA reactivity; epigenetic effects; risk assessment; threshold

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BENZIDINE; BUTYLATED HYDROXYANISOLE; CARCINOGEN; CHEMICAL AGENT; DIETHYLNITROSAMINE; FORMALDEHYDE; LIMONENE; N (2 FLUORENYL)ACETAMIDE; PHENOBARBITAL; SACCHARIN; VINYL CHLORIDE;

CANCER RISK; CARCINOGENICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SHORT SURVEY;

EID: 0029780851     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0163-7258(96)90014-5     Document Type: Short Survey

References (7)

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2. 2u-globulin: association with chemically induced renal toxicity and neoplasia in the male rat EPA/625/3-0/019F 1991
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4. R. Kroes Contribution of toxicology towards risk assessment of carcinogens Arch. Toxicol. 60 1987 224 228 (Suppl.)
5. Office of Science Technology Policy (OSTP) Chemical carcinogens: a review of the science and its associated principles Federal Register 50 1985 10372 10442
6. J.H. Weisburger G.M. Williams Carcinogen testing: current problems and new approaches Science 214 1981 401 407
7. J. Whysner G.M. Williams International cancer risk assessment: the impact of biologic mechanisms Reg. Toxicol. Pharmacol. 15 1992 41 50