Challenging Dogma: Thresholds for Genotoxic Carcinogens? The Case of Vinyl Acetate

Annual Review of Pharmacology and Toxicology

Volumn 43, Issue , 2003, Pages 485-520

  Hengstler, J G ^a   Bogdanffy, M S ^a,b   Bolt, H M ^c   Oesch, F ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b DUPONT COMPANY   (United States)

^c LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Acetaldehyde; Acetic acid; DNA damage; Olfactory tissue; Physiological modeling

Indexed keywords

ACETALDEHYDE; ACETIC ACID; AFLATOXIN B1; CARCINOGEN; DIETHYLNITROSAMINE; KETONE; NITROSOKETONE; UNCLASSIFIED DRUG; VINYL ACETATE; DNA; MUTAGENIC AGENT; VINYL DERIVATIVE;

APOPTOSIS; CARCINOGENESIS; CARCINOGENICITY; CELL CYCLE; CELL PH; CELL PROLIFERATION; CELL REGENERATION; CHROMOSOME ABERRATION; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; GENOTOXICITY; HUMAN; IMMUNE SYSTEM; MAXIMUM ALLOWABLE CONCENTRATION; METABOLIC ACTIVATION; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; TOBACCO; TOXICOKINETICS; ANIMAL; CARCINOGEN TESTING; CLASSIFICATION; DRUG EFFECT;

NICOTIANA TABACUM;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MUTAGENS; RISK ASSESSMENT; VINYL COMPOUNDS;

EID: 0012902275     PISSN: 03621642     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pharmtox.43.100901.140219     Document Type: Review

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