The regulated assembly of a PKCe complex controls the completion of cytokinesis

Nature Cell Biology

Volumn 10, Issue 8, 2008, Pages 891-901

  Saurin, Adrian T ^a   Durgan, Joanne ^a   Cameron, Angus J ^a   Faisal, Amir ^a   Marber, Michael S ^b   Parker, Peter J ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSIN ADENOSINE TRIPHOSPHATASE; PROTEIN 14 3 3; PROTEIN KINASE C EPSILON; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SERINE;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CYCLE ARREST; CELL DIVISION; CHEMICAL GENETICS; CONTROLLED STUDY; CYTOKINESIS; DAUGHTER CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; GENETIC TRANSFECTION; METABOLISM; MOUSE; PHOSPHORYLATION;

14-3-3 PROTEINS; ANIMALS; CELL LINE; CYTOKINESIS; HUMANS; MICE; PHOSPHORYLATION; PROTEIN KINASE C-EPSILON; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 48649090538     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1749     Document Type: Article

References (37)

1. Mellor, H. & Parker, P. J. The extended protein kinase C superfamily. Biochem. J. 332, 281-292 (1998).
2. Newton, A. C. Protein kinase C: Structure, function, and regulation. J. Biol. Chem. 270, 28495-28498 (1995).
3. Bridges, D. & Moorhead, G. B. 14-3-3 proteins: A number of functions for a numbered protein, Sci. STKE 2005, re1O (2005).
4. Yaffe, M. B. et al. The structural basis for 14-3-3:pHosphopeptide binding specificity. Cell 91, 961-971 (1997).
5. Lo, M. C., Gay, F., Odom, R., Shi, Y. & Lin, R. Phosphorylation by the β-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans. Cell 117, 95-106 (2004).
6. LeBron, C., Chen, L., Gilkes, D. M. & Chen, J. Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J. 25 1196-1206 (2006).
7. Obsil, T., Ghirlando, R., Klein, D. C., Ganguly, S. & Dyda, F. Crystal structure of the 14-3-3ζ :sErotonin N-acetyltransferase complex. A role for scaffolding in enzyme regulation. Cell 105, 257-267 (2001).
8. Han, D. C., Rodriguez, L. G. & Guan, J. L. Identification of a novel interaction between integrin betal and 14-3-3β. Oncogene 20 346-357 (2001).
9. Benton, R. & St Johnston, D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/RAR-3 toestablish complementary cortical domains in polarized cells. Cell 115, 691-704 (2003).
10. Peng, C. Y. et al. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501-1505 (1997).
11. Eggert, U. S., Mitchison, T. J. & Field, C. M. Animal cytokinesis: From parts list to mechanisms. Annu. Rev. Biochem. 75, 543-566 (2006).
12. Glotzer, M. The molecular requirements for cytokinesis. Science 307, 1735-1739 (2005).
13. Fujiwara, T. et al. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437, 1043-1047 (2005).
14. Nguyen, T. A., Takemoto, L. J. & Takemoto, D. J. Inhibition of gap junction activity through the release ofthe C1B domain of protein kinase Cgamma (PKCγ) from 14-3-3: Identification of PKCγ-binding sites. J. Biol. Chem. 279, 52714-52725 (2004).
15. Dai, J. G. & Murakami, K. Constitutively and autonomously active protein kinase C associated with 14-3-3 ζ in the rodent brain. J. Neurochem. 84, 23-34 (2003).
16. Durgan, J. et al. The identification and characterisation of novel PKCε phosphorylation sites provides evidence for functional cross-talk within the PKC superfamily. Biochem. J. 411, 319-331 (2008).
17. Aitken, A. 14-3-3 proteins: A historic overview. Semin. Cancer Biol. 16, 162-172 (2006).
18. Eyers, P. A., van den, I. P., Quinlan, R. A., Goedert, M. & Cohen, P. Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580. FEBS Lett. 451, 191-196 (1999).
19. Fiol, C. J., Wang, A., Roeske, R. W. & Roach, P. J. Ordered multisite protein phosphorylation. Analysis of glycoge synthase kinase 3 action using model peptide substrates. J. Biol. Chem. 265, 6061-6065 (1990).
20. Wilker, E. W. et al. 14-3-3σ controls mitotic translation to facilitate cytokinesis. Nature 446, 329-332 (2007).
21. Thorson, J. A. et al. 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Mol. Cell Biol. 18, 5229-5238 (1998).
22. Wilker, E. W., Grant, R. A., Artim, S. C. & Yaffe, M. B. A structural basis for 14-3-3σ functional specificity. J. Biol. Chem. 280 18891-18898 (2005).
23. Bishop, A. C. et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401 (2000).
24. Emoto, K., Inadome, H., Kanaho, Y., Narumiya, S. & Umeda, M. Local change in phospholipid composition at the cleavage Purrow is essential for completion of cytokinesis. J. Biol. Chem. 280, 37901-37907 (2005).
25. Emoto, K. & Umeda, M. An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. J. Cell Biol. 149 1215-1224 (2000).
26. Dadke, D., Jarnik, M., Pugacheva, E. N., Singh, M. K. & Golemis, E. A. Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA.activation cycle. Mol. Biol. Cell 17, 1204-1217 (2006).
27. Yuce, O., Piekny, A. & Glotzer, M. An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170, 571-582 (2005).
28. Minoshima, Y. et al. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev. Cell 4, 549-560 (2003).
29. Shi, Q. & King, R. W. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature 437, 1038-1042 (2005).
30. Li, F., Wang, X., Bunger, P. C. & Gerdes, A. M. Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring. J. Mol. Cell. Cardiol. 29, 1541-1551 (1997).
31. Geddis, A. E., Fox, N. E., Tkachenko, E. & Kaushansky, K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle 6, 455-460 (2007).
32. Faisal, A., Saurin, A., Gregory, B., Foxwell, B. & Parker, P. J. The scaffold MYD88 acts to couple protein kinase C ε (PKCε) to toll-like receptors. J. Biol. Chem. advance online publication, doi 10:1074/jbc.M710330200 (5 May 2008).
33. Saurin, A. T. et al. Targeted disruption of the protein kinase C ε gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc. Res. 55, 672-680 (2002).
34. Griner, E. M. & Kazanietz, M. G. Protein kinase C and other diacylglycerol effectors in cancer. Nature Rev. 7, 281-294 (2007).
35. Kim, L. & Kimmel, A. R. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr. Opin. Genet. Dev. 10, 508-514 (2000).
36. Olson, J. M. & Hallahan, A. R. p38 MAP kinase: A convergence point in cancer therapy. Trends Mol. Med. 10, 125-129 (2004).
37. Ivaska, J., Whelan, R. D., Watson, R. & Parker, P. J. PKCε controls the traffi of β1 integrins in motile cells. EMBO J. 21, 3608-3619 (2002).