Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7148-7166

  Hruschka, Svenja ^a   Rosen, Thomas C ^a   Yoshida, Shinichi ^b   Kirk, Kenneth L ^c   Fröhlich, Roland ^a   Wibbeling, Birgit ^a   Haufe, Günter ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Tottori Institute of Industrial Technology   (Japan)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Fluorinated phenylcyclopropylamine; Irreversible inhibition; Monoamine oxidase; Stereochemistry; Tranylcypromine

Indexed keywords

1 PHENYLCYCLOPROPYLAMINE; 2 FLUORO 1,2 DIPHENYLCYCLOPROPYLAMINE; 2 FLUORO 2 (3,4 DIMETHOXYPHENYL)CYCLOPROPYLAMINE; 2 FLUORO 2 (4 FLUOROPHENYL)CYCLOPROPYLAMINE; 2 FLUORO 2 (4 METHOXYPHENYL)CYCLOPROPYLAMINE; 2 FLUORO 2 (4 TRIFLUOROMETHYLPHENYL)CYCLOPROPYLAMINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CYCLOPROPANE DERIVATIVE; MONOAMINE OXIDASE INHIBITOR; TRANYLCYPROMINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; DIASTEREOISOMER; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORINATION; PKA; STEREOCHEMISTRY;

CYCLOPROPANES; ELECTRONS; FLUORINE; HUMANS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR BIOLOGY; MONOAMINE OXIDASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48649085206     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.048     Document Type: Article

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