45S rDNA regions are chromosome fragile sites expressed as gaps in vitro on metaphase chromosomes of root-tip meristematic cells in Lolium spp

PLoS ONE

Volumn 3, Issue 5, 2008, Pages

  Huang, Jing ^a   Ma, Lu ^a   Yang, Fei ^a   Fei, Shui Zhang ^b   Li, Lijia ^a  

^a WUHAN UNIVERSITY   (China)

^b IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; RIBOSOME DNA; RIBOSOME DNA 45S;

ARTICLE; CHROMATIN; CHROMOSOME 14; CHROMOSOME BREAKAGE; CHROMOSOME DAMAGE; CHROMOSOME FRAGILE SITE; CHROMOSOME MAP; CHROMOSOME NUMBER; CHROMOSOME PREPARATION; FLUORESCENCE IN SITU HYBRIDIZATION; LOLIUM; MERISTEMATIC CELL; METAPHASE CHROMOSOME; NONHUMAN; PLANT CELL; PLANT CHROMOSOME; CYTOLOGY; GENETICS; HUMAN; METABOLISM; METAPHASE; MITOSIS; NUCLEOTIDE REPEAT;

LOLIUM; LOLIUM PERENNE;

CHROMATIN; CHROMOSOME FRAGILE SITES; CHROMOSOMES, PLANT; DNA, RIBOSOMAL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LOLIUM; METAPHASE; MITOSIS; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 48249130846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002167     Document Type: Article

References (54)

1. Robert-Fortel I, Junéra HR, Géraud G, Hernadez-Verdun D (1993) Three-dimensional organization of the ribosomal genes and Ag-NOR proteins during interphase and mitosis in PtK 1 cells studied by confocal microscopy. Chromosoma 102: 146-157.
2. Richards RI (2001) Fragile and unstable chromosomes in cancer: causes and consequences. Trends Genet 17: 339-345.
3. Glover TW (2006) Common fragile sites. Cancer Lett 232: 4-12.
4. Magenis RE, Hecht F, Lovrien EW (1970) Heritable fragile site on chromosome 16: probable localization of haptoglobin locus in man. Science 170: 85-87.
5. Buttel I, Fechter A, Schwab M (2004) Common fragile sites and cancer: targeted cloning by insertional mutagenesis. Ann NY Acad Sci 1028: 14-27.
6. Sutherland GR, Baker E, Richards RI (1998) Fragile sites still breaking. Trends Genet 14: 501-506.
7. Huebner K, Croce CM (2001) FRA3B and other common fragile sites: the weakest links. Nat Rev Cancer 1: 214-221.
8. Glover TW, Berger C, Coyle J, Echo B (1984) DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum Genet 67: 136-142.
9. Nelson DL (1995) The fragile X syndromes. Semin Cell Biol 6: 5-11.
10. Popescu NC (2003) Genetic alterations in cancer as a result of breakage at fragile sites. Cancer Lett 192: 1-17.
11. Boldog FL, Waggoner B, Glover TW, Chumakov I, Le Paslier D, et al. (1994) Integrated YAC contig containing the 3p14. 2 hereditary renal carcinoma 3; 8 translocation breakpoint and the fragile site FRA3B. Genes Chromosomes Cancer 11: 216-221.
12. Laird C, Jaffe E, Karpen G, Lamb M, Nelson R (1987) Fragile sites in human chromosomes as regions of late-replicating DNA. Trends Genet 3: 274-281.
13. Handt O, Baker E, Dayan S, Gartler SM, Woollatt E, et al. (2000) Analysis of replication timing at the FRA10B and FRA16B fragile site loci. Chromosome Res 8: 677-688.
14. Coffee B, Zhang F, Ceman S, Warren ST, Reines D (2002) Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile X syndrome. Am J Hum Genet 71: 923-932.
15. Wang Y (2006) Chromatin structure of human chromosomal fragile sites. Cancer Lett 232: 70-78.
16. Gericke GS (1999) Chromosomal fragility may be indicative of altered higher-order DNA organization as the underlying genetic diathesis in complex neurobehavioural disorders. Med Hypotheses 52: 201-208.
17. Casper AM, Nghiem P, Arlt MF, Glover TW (2002) ATR regulates fragile site stability. Cell 111: 779-789.
18. Rassool FV, McKeithan TW, Neilly ME, Melle EV, Espinosa R III, et al. (1991) Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites. Proc Natl Acad Sci USA 88: 6657-6661.
19. Coquelle A, Pipiras E, Toledo F, Buttin G, Debatisse M (1997) Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell 89: 215-225.
20. Schwartz M, Zlotorynski E, Kerem B (2006) The molecular basis of common and rare fragile sites. Cancer Lett 232: 13-26.
21. Winfield MO, Schmitt M, Lorz H, Davey MR, Karp A (1995) Nonrandom chromosome variation and morphogenic potential in cell lines of bread wheat. Genome 38: 869-878.
22. Morgan WG, King IP, Harper JA, Thomas HM (2000) The cytogenetic analysis of a Robertsonian rearrangement in Lolium multiflorum. Cytologia 65: 173-177.
23. Thomas HM, Harper JA, Meredith MR, Morgan WG, Thomas ID, et al. (1996) Comparisons of ribosomal DNA sites in Lolium species by fluorescent in situ hybridization. Chromosome Res 4: 486-490.
24. Cimprich KA (2003) Fragile Sites: breaking up over a slowdown. Curr Biol 13: 231-233.
25. Thomas HM, Harper JA, Morgan WG (2001) Gross chromosome rearrangements are occurring in an accession of the grass Lolium rigidum. Chromosome Res 9: 585-590.
26. Siroky J, Zluvova J, Riha K, Shippen DE, Vyskot B (2003) Rearrangements of ribosomal DNA clusters in late generation telomerase-deficient Arabidopsis. Chromosoma 112: 116-123.
27. Schubert I, Wobus U (1985) In situ hybridization confirms jumping nucleolus organizing regions in Allium. Chromosoma 92: 143-148.
28. Butler DK (1992) Ribosomal DNA is a site of chromosome breakage in aneuploid strains of Neurospora. Genetics 131: 581-592.
29. Perkins DD, Raju NB, Barry EG, Butler DK (1995) Chromosome rearrangements that involve the nucleolus organizer region in Neurospora. Genetics 141: 909-923.
30. Boldog F, Gemmill RM, West J, Robinson M, Robinson L, et al. (1997) Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B. Hum Mol Genet 6: 193-203.
31. Mishmar D, Rahat A, Scherer SW, Nyakatura G, Hinzmann B, et al. (1998) Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc Natl Acad Sci USA 95: 8141-8146.
32. Ried K, Finnis M, Hobson L, Mangelsdorf M, Dayan S, et al. (2000) Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells. Hum Mol Genet 9: 1651-1663.
33. Arlt MF, Xu B, Durkin SG, Casper AM, Kastan MB, et al. (2004) BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. Mol Cell Biol 24: 6701-6709.
34. Wang YH, Griffith J (1996) Methylation of expanded CCG triplet repeat DNA from fragile X syndrome patients enhances nucleosome exclusion. J Biol Chem 271: 22937-22940.
35. Yu S, Mangelsdorf M, Hewett D, Hobson L, Baker E, et al. (1997) Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat. Cell 88: 367-374.
36. Fan Q, Yao MC, Journals O (2000) A long stringent sequence signal for programmed chromosome breakage in Tetrahymena thermophila. Nucleic Acids Res 28: 895-900.
37. Yao MC (1981) Ribosomal RNA gene amplification in Tetrahymena may be associated with chromosome breakage and DNA elimination. Cell 24: 765-774.
38. Culligan K, Tissier A, Britt A (2004) ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana. Plant Cell 16: 1091-1104.
39. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, et al. (2000) Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Gene Dev 14: 2989-3002.
40. Gatei M, Shkedy D, Khanna KK, Uziel T, Shiloh Y, et al. (2001) Ataxiatelangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene 20: 289-294.
41. Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC (2002) BRCA1 regulates the G 2/M checkpoint by activating Chk 1 kinase upon DNA damage. Nat Genet 30: 285-289.
42. Ramanathan B, Smerdon MJ (1989) Enhanced DNA repair synthesis in hyperacetylated nucleosomes. J Biol Chem 264: 11026-11034.
43. Gu Y, Shen Y, Gibbs RA, Nelson DL (1996) Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Nat Genet 13: 109-113.
44. Pomponi MG, Neri G (1994) Butyrate and acetyl-carnitine inhibit the cytogenetic expression of the fragile X in vitro. Am J Med Genet 51: 447-450.
45. Conconi A, Widmer RM, Koller T, Sogo JM (1989) Two different chromatin structures coexist in ribosomal RNA genes throughout the cell cycle. Cell 57: 753-761.
46. Lawrence RJ, Earley K, Pontes O, Silva M, Chen ZJ, et al. (2004) A concerted DNA methylation/histone methylation switch regulates rRNA gene dosage control and nucleolar dominance. Mol Cell 13: 599-609.
47. McStay B (2006) Nucleolar dominance: a model for rRNA gene silencing. Gene Dev 20: 1207-1214.
48. Earley K, Lawrence RJ, Pontes O, Reuther R, Enciso AJ, et al. (2006) Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance. Gene Dev 20: 1283-1293.
49. Huang Y (2002) Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Nucleic Acids Res 30: 1465-1482.
50. Durand-Dubief M, Sinha I, Fagerström-Billai F, Bonilla C, Wright A, et al. (2007) Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing. EMBO J. 26: 2477-2488.
51. Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, et al. (2006) Response to comment on 'HST2 mediates SIR2-independent life-span extension by calorie restriction'. Science 312: 1312.
52. Sutherland G, Jacky P, Baker E (1984) Heritable fragile sites on human chromosomes. XI. Factors affecting expression of fragile sites at 10q25, 16q22, and 17p12. Am J Hum Genet 36: 110-122.
53. Song YC, Gustafson JP (1995) The physical location of fourteen RFLP markers in rice (Oryza sativa L.). Theor Appl Genet 90: 113-119.
54. Li LJ, Arumuganathan K, Rines HW, Phillips RL, Riera-Lizarazu O, et al. (2001) Flow cytometric sorting of maize chromosome 9 from an oat-maize chromosome addition line. Theor Appl Genet 102: 658-663.