The clock proteins, aging, and tumorigenesis

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 72, Issue , 2007, Pages 477-482

  Kondratov, R V ^a   Antoch, M P ^b  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; PROTEIN BMAL1; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR ARNTL;

AGING; ANIMAL; BIOLOGICAL MODEL; CIRCADIAN RHYTHM; EVALUATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MOUSE; MOUSE MUTANT; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREMATURE AGING; REVIEW; CARCINOGENESIS; CELL CYCLE REGULATION; GENE EXPRESSION; GENOTOXICITY; MOLECULAR CLOCK; NONHUMAN; PHYSIOLOGICAL PROCESS; RADIATION DOSE;

AGING; AGING, PREMATURE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CIRCADIAN RHYTHM; HUMANS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; NEOPLASMS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 48249107391     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2007.72.050     Document Type: Conference Paper

References (43)

1. Antoch M.P., Kondratov R.V., and Takahashi J.S. 2005. Circadian clock genes as modulators of sensitivity to genotoxic stress. Cell Cycle 4: 901.
2. Balaban R.S., Nemoto S., and Finkel T. 2005. Mitochondria, oxidants, and aging. Cell 120: 483.
3. Bell-Pedersen D., Cassone V.M., Earnest D.J., Golden S.S., Hardin P.E., Thomas T.L., and Zoran M.J. 2005. Circadian rhythms from multiple oscillators: Lessons from diverse organisms. Nat. Rev. Genet. 6: 544.
4. Bunger M.K., Walisser J.A., Sullivan R., Manley P.A., Moran S.M., Kalscheur V.L., Colman R.J., and Bradfield C.A. 2005. Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Genesis 41: 122.
5. Bunger M.K., Wilsbacher L.D., Moran S.M., Clendenin C., Radcliffe L.A., Hogenesch J.B., Simon M.C., Takahashi J.S., and Bradfield C.A. 2000. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103: 1009.
6. Chen S.T., Choo K.B., Hou M.F., Yeh K.T., Kuo S.J., and Chang J.G. 2005. Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Carcinogenesis 26: 1241.
7. Curtis A.M., Cheng Y., Kapoor S., Reilly D., Price T.S., and Fitzgerald G.A. 2007. Circadian variation of blood pressure and the vascular response to asynchronous stress. Proc. Natl. Acad. Sci. 104: 3450.
8. Curtis A.M., Seo S.B., Westgate E.J., Rudic R.D., Smyth E.M., Chakravarti D., FitzGerald G.A., and McNamara P. 2004. Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J. Biol. Chem. 279: 7091.
9. DeBruyne J.P., Weaver D.R., and Reppert S.M. 2007. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat. Neurosci. 10: 543.
10. DeBruyne J.P., Noton E., Lambert C.M., Maywood E.S., Weaver D.R., and Reppert S.M. 2006. A clock shock: Mouse CLOCK is not required for circadian oscillator function. Neuron 50: 465.
11. Fu L., Pelicano H., Liu J., Huang P., and Lee C. 2002. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111: 41.
12. Gachon F., Olela F.F., Schaad O., Descombes P., and Schibler U. 2006. The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab. 4: 25.
13. Gauger M.A. and Sancar A. 2005. Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer. Cancer Res. 65: 6828.
14. Gekakis N., Staknis D., Nguyen H.B., Davis F.C., Wilsbacher L.D., King D.P., Takahashi J.S., and Weitz C.J. 1998. Role of the CLOCK protein in the mammalian circadian mechanism. Science 280: 1564.
15. Gery S., Komatsu N., Baldjyan L., Yu A., Koo D., and Koeffler H.P. 2006. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol. Cell 22: 375.
16. Giacchetti S. 2002. Chronotherapy of colorectal cancer. Chronobiol. Int. 19: 207.
17. Gorbacheva V.Y., Kondratov R.V., Zhang R., Cherukuri S., Gudkov A.V., Takahashi J.S., and Antoch M.P. 2005. Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex. Proc. Natl. Acad. Sci. 102: 3407.
18. Hendricks J.C., Lu S., Kume K., Yin J.C., Yang Z., and Sehgal A. 2003. Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J. Biol. Rhythms 18: 12.
19. Hrushesky W.J. 1985. Circadian timing of cancer chemotherapy. Science 228: 73.
20. Hua H., Wang Y., Wan C., Liu Y., Zhu B., Wang X., Wang Z., and Ding J.M. 2007. Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Cancer Gene Ther. 14: 815.
21. Kennaway D.J. 2005. The role of circadian rhythmicity in reproduction. Hum. Reprod. Update 11: 91.
22. Ko C.H. and Takahashi J.S. 2006. Molecular components of the mammalian circadian clock. Hum. Mol. Genet. (spec. no. 2) 15: R271.
23. Kobayashi M., Wood P.A., and Hrushesky W.J. 2002. Circadian chemotherapy for gynecological and genitourinary cancers. Chronobiol. Int. 19: 237.
24. Kondratov R.V. and Antoch M.P. 2007. Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol. 17: 311.
25. Kondratov R.V., Gorbacheva V.Y., and Antoch M.P. 2007. The role of mammalian circadian proteins in normal physiology and genotoxic stress responses. Curr. Top. Dev. Biol. 78: 173.
26. Kondratov R.V., Kondratova A.A., Gorbacheva V.Y., Vykhovanets O.V., and Antoch M.P. 2006a. Early aging and age-related pathologies in mice deficient in BMAL1, the core component of the circadian clock. Genes Dev. 20: 1868.
27. Kondratov R.V., Shamanna R.K., Kondratova A.A., Gorbacheva V.Y., and Antoch M.P. 2006b. Dual role of the CLOCK/BMAL1 circadian complex in transcriptional regulation. FASEB J. 20: 530.
28. Krugluger W., Brandstaetter A., Kallay E., Schueller J., Krexner E., Kriwanek S., Bonner E., and Cross H.S. 2007. Regulation of genes of the circadian clock in human colon cancer: Reduced period-1 and dihydropyrimidine dehydrogenase transcription correlates in high-grade tumors. Cancer Res. 67: 7917.
29. Lee C.C. 2006. Tumor suppression by the mammalian Period genes. Cancer Causes Control 17: 525.
30. Levi F. 2001. Circadian chronotherapy for human cancers. Lancet Oncol. 2: 307.
31. Levi F. and Schibler U. 2007. Circadian rhythms: Mechanisms and therapeutic implications. Annu. Rev. Pharmacol. Toxicol. 47: 593.
32. Matsuo T., Yamaguchi S., Mitsui S., Emi A., Shimoda F., and Okamura H. 2003. Control mechanism of the circadian clock for timing of cell division in vivo. Science 302: 255.
33. Miller B.H., McDearmon E.L., Panda S., Hayes K.R., Zhang J., Andrews J.L., Antoch M.P., Walker J.R., Esser K.A., Hogenesch J.B., and Takahashi J.S. 2007. Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation Proc. Natl. Acad. Sci. 104: 3342.
34. Panda S., Antoch M.P., Miller B.H., Su A.I., Schook A.B., Straume M., Schultz P.G., Kay S.A., Takahashi J.S., and Hogenesch J.B. 2002. Coordinated transcription of key pathways in the mouse by circadian clock. Cell 109: 307.
35. Rudic R.D., McNamara P., Curtis A.M., Boston R.C., Panda S., Hogenesch J.B., and Fitzgerald G.A. 2004. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol. 2: e377.
36. Sahar S. and Sassone-Corsi P. 2007. Circadian clock and breast cancer: A molecular link. Cell Cycle 6: 1329.
37. Schibler U. and Sassone-Corsi P. 2002. A web of circadian pacemakers. Cell 111: 919.
38. Shimba S., Ishii N., Ohta Y., Ohno T., Watabe Y., Hayashi M., Wada T., Aoyagi T., and Tezuka M. 2005. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc. Natl. Acad. Sci. 102: 12071.
39. Storch K.F., Lipan O., Leykin I., Viswanathan N., Davis F.C., Wong W.H., and Weitz C.J. 2002. Extensive and divergent circadian gene expression in liver and heart. Nature 417: 78.
40. Turek F.W., Joshu C., Kohsaka A., Lin E., Ivanova G., McDearmon E., Laposky A., Losee-Olson S., Easton A., Jensen D.R., Eckel R.H., Takahashi J.S., and Bass J. 2005. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308: 1043.
41. Vitaterna M.H., King D.P., Chang A.M., Kornhauser J.M., Lowrey P.L., McDonald J.D., Dove W.F., Pinto L.H., Turek F.W., and Takahashi J.S. 1994. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719.
42. Woon P.Y., Kaisaki P.J., Braganca J., Bihoreau M.T., Levy J.C., Farrall M., and Gauguier D. 2007. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc. Natl. Acad. Sci. 104: 14412.
43. Yeh K.T., Yang M.Y., Liu T.C., Chen J.C., Chan W.L., Lin S.F., and Chang J.G. 2005. Abnormal expression of period 1 (PER1) in endometrial carcinoma. J. Pathol. 206: 111.