Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice

Cancer Gene Therapy

Volumn 14, Issue 9, 2007, Pages 815-818

  Hua, H ^a,b   Wang, Y ^b   Wan, C ^b   Liu, Y ^b   Zhu, B ^b   Wang, X ^c   Wang, Z ^b   Ding, J M ^c  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Circadian clock genes; Period2; Tumorigenesis

Indexed keywords

PER2 PROTEIN; PROTEIN MPER2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENESIS; CELL CYCLE; CELL GROWTH; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG INHIBITION; GENE TARGETING; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LEWIS CARCINOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CARCINOMA, LEWIS LUNG; CELL CYCLE PROTEINS; CIRCADIAN RHYTHM; DNA PRIMERS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRALESIONAL; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

MAMMALIA; MUS;

EID: 34547862425     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/sj.cgt.7701061     Document Type: Article

References (12)

1. Young MW, Kay SA. Time zones: a comparative genetics of circadian clocks. Nat Rev Genet 2001; 2: 702-715.
2. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature 2002; 418: 935-941.
3. Reick M, Garcia JA, Dudley C, McKnight SL. NPAS2: an analog of clock operative in the mammalian forebrain. Science 2001; 293: 506-509.
4. Smaaland R, Laerum OD, Lote K, Sletvold O, Sothern RB, Bjerknes R. DNAsynthesis in human bone marrow is circadian stage dependent. Blood 1991; 77: 2603-2611.
5. Smaaland R. Circadian rhythm of cell division. Prog Cell Cycle Res 1996; 2: 241-266.
6. Filipski E, King VM, Li X, Granda TG, Mormont MC, Liu X et al. Host circadian clock as a control point in tumor progression. J Natl Cancer Inst 2002; 94: 690-697.
7. Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNAdamage response in vivo. Cell 2002; 111: 41-50.
8. Hua H, Wang Y, Wan C, Liu Y, Zhu B, Yang C et al. Circadian gene mPer2 overexpression induces cancer cell apoptosis. Cancer Sci 2006; 97: 589-596.
9. Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, Demeneix B et al. Aversatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297-7301.
10. Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP. profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia. Blood 2005; 106: 2827-2836.
11. Jianguo L, Guantham M, Xiaoyan S, Mark M, Susana C-R, Xiaojing M et al. The circadian clock Period 2 gene regulates gamma interferon production of NK cells in host response to lipopolysaccharide-induced endotoxic shock. Infect Immun 2006; 74: 4750-4756.
12. Granda TG, Liu XH, Smaaland R, Cermakian N, Filipski E, Sassone-Corsi P et al. Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor. FASEB J 2005; 19: 304-306.