메뉴 건너뛰기




Volumn 8, Issue 3, 2008, Pages 201-207

Cystic fibrosis, vector-mediated gene therapy, and relevance of toll-like receptors: A review of problems, progress, and possibilities

Author keywords

Cystic fibrosis; Gene therapy; Nonviral vectors; Progress; Toll like receptors; Transfection; Viral vectors

Indexed keywords

ADENOVIRUS VECTOR; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; DENUFOSOL; DURAMYCIN; LENTIVIRUS VECTOR; LIPOSOME; NAKED DNA; PARVOVIRUS VECTOR; POLYMER; RETROVIRUS VECTOR; TOLL LIKE RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; VIRUS VECTOR;

EID: 48249099755     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652308784746468     Document Type: Review
Times cited : (10)

References (67)
  • 1
    • 0024424270 scopus 로고
    • Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
    • Riordan JR, Rommens JM, Kerem B, et al. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073 (1989).
    • (1989) Science , vol.245 , pp. 1066-1073
    • Riordan, J.R.1    Rommens, J.M.2    Kerem, B.3
  • 2
    • 20444366909 scopus 로고    scopus 로고
    • The gallbladder and biliary tract in cystic fibrosis
    • Curry MP, Hegarty JE. The gallbladder and biliary tract in cystic fibrosis. Curr Gastroenterol Rep 7(2): 147-53 (2005).
    • (2005) Curr Gastroenterol Rep , vol.7 , Issue.2 , pp. 147-153
    • Curry, M.P.1    Hegarty, J.E.2
  • 3
    • 0022413731 scopus 로고
    • A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7
    • Knowlton RG, Cohen-Haguenauer O, Van Cong N, et al. A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7. Nature 318: 380-382 (1985).
    • (1985) Nature , vol.318 , pp. 380-382
    • Knowlton, R.G.1    Cohen-Haguenauer, O.2    Van Cong, N.3
  • 4
    • 0022361686 scopus 로고
    • A closely linked genetic marker for cystic fibrosis
    • White R, Woodward S, Leppert M et al. A closely linked genetic marker for cystic fibrosis. Nature 318: 382-384 (1985).
    • (1985) Nature , vol.318 , pp. 382-384
    • White, R.1    Woodward, S.2    Leppert, M.3
  • 5
    • 0022385943 scopus 로고
    • Localization of cystic fibrosis locus to human chromosome 7cen-q22
    • Wainwright BJ, Scambler PJ, Schmodtke J, et al. Localization of cystic fibrosis locus to human chromosome 7cen-q22. Nature 318: 384-385 (1985).
    • (1985) Nature , vol.318 , pp. 384-385
    • Wainwright, B.J.1    Scambler, P.J.2    Schmodtke, J.3
  • 6
    • 0024423668 scopus 로고
    • Identification of the cystic fibrosis gene: Genetic analysis
    • Kerem B, Rommens JM, Buchanan JA, et al. Identification of the cystic fibrosis gene: Genetic analysis. Science 245:1073-1079 (1989).
    • (1989) Science , vol.245 , pp. 1073-1079
    • Kerem, B.1    Rommens, J.M.2    Buchanan, J.A.3
  • 7
    • 27544434744 scopus 로고    scopus 로고
    • Developmental paradigm for early features of cystic fibrosis
    • Larson JE, Cohen JC. Developmental paradigm for early features of cystic fibrosis. Pediatr Pulmonol 40(5): 371-377 (2005).
    • (2005) Pediatr Pulmonol , vol.40 , Issue.5 , pp. 371-377
    • Larson, J.E.1    Cohen, J.C.2
  • 8
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H, Grubb BR, Tarran R, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95: 1005-1015 (1998).
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3
  • 9
    • 0028920643 scopus 로고
    • Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface
    • Imundo L, Barasch J, Prince A, Al-Awqati Q. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proc Natl Acad Sci USA 92: 3019-3023 (1995).
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3019-3023
    • Imundo, L.1    Barasch, J.2    Prince, A.3    Al-Awqati, Q.4
  • 10
    • 0026523829 scopus 로고
    • Cystic fibrosis: Molecular biology and therapeutic implications
    • Collins FS. Cystic fibrosis: molecular biology and therapeutic implications. Science 256(5058): 774-779 (1992).
    • (1992) Science , vol.256 , Issue.5058 , pp. 774-779
    • Collins, F.S.1
  • 11
    • 0026918861 scopus 로고
    • Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis
    • Johnson L, Olsen J, Sarkadi B, et al. Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nat Genet 2: 21-5 (1992).
    • (1992) Nat Genet , vol.2 , pp. 21-25
    • Johnson, L.1    Olsen, J.2    Sarkadi, B.3
  • 12
    • 0036846329 scopus 로고    scopus 로고
    • Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis
    • Ramalho AS, Beck S, Meyer M, et al. Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis. Am J Respir Cell Mol Biol 5: 619-27 (2002).
    • (2002) Am J Respir Cell Mol Biol , vol.5 , pp. 619-627
    • Ramalho, A.S.1    Beck, S.2    Meyer, M.3
  • 13
    • 0036354946 scopus 로고    scopus 로고
    • Gene therapy for inherited lung disorders: An insight into pulmonary defence
    • Vadolas J, Williamson R, Ioannou PA. Gene therapy for inherited lung disorders: an insight into pulmonary defence. Pulmon Pharmacol Therapeut 15: 61-72 (2002).
    • (2002) Pulmon Pharmacol Therapeut , vol.15 , pp. 61-72
    • Vadolas, J.1    Williamson, R.2    Ioannou, P.A.3
  • 14
    • 4644359324 scopus 로고    scopus 로고
    • CFTR transgene expression in primary DeltaF508 epithelial cell cultures from human nasal polyps following gene transfer with cationic phosphonolipids
    • Montier T, Delépine P, Marianowski R, et al. CFTR transgene expression in primary DeltaF508 epithelial cell cultures from human nasal polyps following gene transfer with cationic phosphonolipids. Mol Biotechnol 26(3): 193-206 (2004).
    • (2004) Mol Biotechnol , vol.26 , Issue.3 , pp. 193-206
    • Montier, T.1    Delépine, P.2    Marianowski, R.3
  • 15
    • 34250222751 scopus 로고    scopus 로고
    • Genomic context vectors and artificial chromosomes for cystic fibrosis gene therapy
    • Conese M, Boyd AC, Di Gioia S, et al. Genomic context vectors and artificial chromosomes for cystic fibrosis gene therapy. Curr Gene Ther 7(3): 175-187 (2007).
    • (2007) Curr Gene Ther , vol.7 , Issue.3 , pp. 175-187
    • Conese, M.1    Boyd, A.C.2    Di Gioia, S.3
  • 16
    • 0347812926 scopus 로고    scopus 로고
    • The status of gene therapy for cystic fibrosis
    • Weiss DJ, Pilewski JM. The status of gene therapy for cystic fibrosis. Semin Respir Crit Care Med 24(6): 749-70 (2003).
    • (2003) Semin Respir Crit Care Med , vol.24 , Issue.6 , pp. 749-770
    • Weiss, D.J.1    Pilewski, J.M.2
  • 17
    • 33646191190 scopus 로고    scopus 로고
    • Gene therapy for cystic fibrosis airway disease- is clinical success imminent?
    • Anson DS, Smith GJ, Parsons DW. Gene therapy for cystic fibrosis airway disease- is clinical success imminent? Curr Gene Ther 6(2): 161-179 (2006).
    • (2006) Curr Gene Ther , vol.6 , Issue.2 , pp. 161-179
    • Anson, D.S.1    Smith, G.J.2    Parsons, D.W.3
  • 18
    • 26944472870 scopus 로고    scopus 로고
    • Physical and biological barriers to viral vector-mediated delivery of genes to the airway epithelium
    • Pickles RJ. Physical and biological barriers to viral vector-mediated delivery of genes to the airway epithelium. Proc Am Thorac Soc 1(4): 302-308 (2004).
    • (2004) Proc Am Thorac Soc , vol.1 , Issue.4 , pp. 302-308
    • Pickles, R.J.1
  • 19
    • 0028318416 scopus 로고
    • Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats
    • Zabner J, Petersen DM, Puga AP, et al. Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nat Genet 6: 75-83 (1994).
    • (1994) Nat Genet , vol.6 , pp. 75-83
    • Zabner, J.1    Petersen, D.M.2    Puga, A.P.3
  • 20
    • 0025094612 scopus 로고
    • Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer
    • Drumm ML, Pope HA, Cliff WH, et al. Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell 62: 1227-1233 (1990).
    • (1990) Cell , vol.62 , pp. 1227-1233
    • Drumm, M.L.1    Pope, H.A.2    Cliff, W.H.3
  • 21
    • 0025155528 scopus 로고
    • Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
    • Rich DP, Anderson MP, Gregory RJ, et al. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature 347: 358-363 (1990).
    • (1990) Nature , vol.347 , pp. 358-363
    • Rich, D.P.1    Anderson, M.P.2    Gregory, R.J.3
  • 22
    • 0027361622 scopus 로고
    • Noninvasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
    • Alton EW, Middleton PG, Caplen NJ, et al. Noninvasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat Genet 5: 135-142 (1993).
    • (1993) Nat Genet , vol.5 , pp. 135-142
    • Alton, E.W.1    Middleton, P.G.2    Caplen, N.J.3
  • 23
    • 0028913411 scopus 로고
    • Liposomemediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
    • Caplen NJ, Alton EW, Middleton PG, et al. Liposomemediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat Med 1: 39-46 (1995).
    • (1995) Nat Med , vol.1 , pp. 39-46
    • Caplen, N.J.1    Alton, E.W.2    Middleton, P.G.3
  • 24
    • 0028245537 scopus 로고
    • Cationic liposomes for direct gene transfer in therapy of cancer and other diseases
    • Farhood H, Gao X, Son K, et al. Cationic liposomes for direct gene transfer in therapy of cancer and other diseases. Ann N Y Acad Sci 716: 23-34 (1994).
    • (1994) Ann N Y Acad Sci , vol.716 , pp. 23-34
    • Farhood, H.1    Gao, X.2    Son, K.3
  • 25
    • 0033808419 scopus 로고    scopus 로고
    • Human coronavirus 229E infects polarized airway epithelia from the apical surface
    • Wang G, Deering C, Macke M, et al. Human coronavirus 229E infects polarized airway epithelia from the apical surface. J Virol 74(19): 9234-9239 (2000).
    • (2000) J Virol , vol.74 , Issue.19 , pp. 9234-9239
    • Wang, G.1    Deering, C.2    Macke, M.3
  • 26
    • 0036094947 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology
    • Zhang L, Peeples ME, Boucher RC, et al. Respiratory syncytial virus infection of human airway epithelial cells is polarized, specific to ciliated cells, and without obvious cytopathology. J Virol 76(11): 5654-66 (2002).
    • (2002) J Virol , vol.76 , Issue.11 , pp. 5654-5666
    • Zhang, L.1    Peeples, M.E.2    Boucher, R.C.3
  • 27
    • 33748860863 scopus 로고    scopus 로고
    • Kolb M, Martin G, Medina M, et al. Gene therapy for pulmonary diseases. Chest 130: 879-884 (2006).
    • Kolb M, Martin G, Medina M, et al. Gene therapy for pulmonary diseases. Chest 130: 879-884 (2006).
  • 28
    • 33748539369 scopus 로고    scopus 로고
    • Current prospects for gene therapy of cystic fibrosis
    • Ziady AG, Davis PB. Current prospects for gene therapy of cystic fibrosis. Curr Opin Pharmacol 6(5): 515-521 (2006).
    • (2006) Curr Opin Pharmacol , vol.6 , Issue.5 , pp. 515-521
    • Ziady, A.G.1    Davis, P.B.2
  • 29
    • 36749023425 scopus 로고    scopus 로고
    • Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function?
    • Lassance RM, Pássaro CP, Martini SV, et al. Does the use of recombinant AAV2 in pulmonary gene therapy damage lung function? Respir Physiol Neurobiol 160(1): 91-98 (2008).
    • (2008) Respir Physiol Neurobiol , vol.160 , Issue.1 , pp. 91-98
    • Lassance, R.M.1    Pássaro, C.P.2    Martini, S.V.3
  • 31
    • 0027484584 scopus 로고
    • Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector
    • Flotte TP, Afione SA, Conrad C, et al. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc Natl Acad Sci USA 90(22): 10613-10617 (1993).
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.22 , pp. 10613-10617
    • Flotte, T.P.1    Afione, S.A.2    Conrad, C.3
  • 32
    • 0026873533 scopus 로고
    • Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer
    • Olsen JC, Johnson LG, Stutts MJ, et al. Correction of the apical membrane chloride permeability defect in polarized cystic fibrosis airway epithelia following retroviral-mediated gene transfer. Hum Gene Ther 3(3): 253-266 (1992).
    • (1992) Hum Gene Ther , vol.3 , Issue.3 , pp. 253-266
    • Olsen, J.C.1    Johnson, L.G.2    Stutts, M.J.3
  • 33
    • 10744227749 scopus 로고    scopus 로고
    • Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis trans-membrane regulator gene transfer to the lungs of patients with cystic fibrosis: A multicenter, double-blind, placebo-controlled trial
    • Moss RB, Rodman D, Spencer LT, et al. Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis trans-membrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial. Chest 125(2): 509-521 (2004).
    • (2004) Chest , vol.125 , Issue.2 , pp. 509-521
    • Moss, R.B.1    Rodman, D.2    Spencer, L.T.3
  • 34
    • 34548512049 scopus 로고    scopus 로고
    • Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: A randomized placebo-controlled phase 2B trial
    • Moss RB, Milla C, Colombo J, et al. Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial. Hum Gene Ther 18(8): 726-32 (2007).
    • (2007) Hum Gene Ther , vol.18 , Issue.8 , pp. 726-732
    • Moss, R.B.1    Milla, C.2    Colombo, J.3
  • 35
    • 0034992340 scopus 로고    scopus 로고
    • Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors
    • Halbert CL, Allen JM, Miller AD. Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors. J Virol 75(14): 6615-6624 (2001).
    • (2001) J Virol , vol.75 , Issue.14 , pp. 6615-6624
    • Halbert, C.L.1    Allen, J.M.2    Miller, A.D.3
  • 36
    • 17144401470 scopus 로고    scopus 로고
    • Novel molecular approaches to cystic fibrosis gene therapy
    • Lee TW, Matthews DA, Blair GE. Novel molecular approaches to cystic fibrosis gene therapy. Biochem J 387(Pt 1): 1-15 (2005).
    • (2005) Biochem J , vol.387 , Issue.PART 1 , pp. 1-15
    • Lee, T.W.1    Matthews, D.A.2    Blair, G.E.3
  • 37
    • 0029145960 scopus 로고
    • Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase
    • van Ginkel FW, Liu C, Simecka JW, et al. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase. Hum Gene Ther 6(7): 895-903 (1995).
    • (1995) Hum Gene Ther , vol.6 , Issue.7 , pp. 895-903
    • van Ginkel, F.W.1    Liu, C.2    Simecka, J.W.3
  • 38
    • 0031570890 scopus 로고    scopus 로고
    • Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene
    • van Ginkel FW, McGhee JR, Liu C, et al. Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene. J Immunol 159(2): 685-693 (1997).
    • (1997) J Immunol , vol.159 , Issue.2 , pp. 685-693
    • van Ginkel, F.W.1    McGhee, J.R.2    Liu, C.3
  • 39
    • 0035033758 scopus 로고    scopus 로고
    • Stealth adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung
    • Croyle MA, Chirmule N, Zhang Y, Wilson JM. "Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung. J Virol 75(10): 4792-4801 (2001).
    • (2001) J Virol , vol.75 , Issue.10 , pp. 4792-4801
    • Croyle, M.A.1    Chirmule, N.2    Zhang, Y.3    Wilson, J.M.4
  • 40
    • 0034756451 scopus 로고    scopus 로고
    • Expanding AAV packaging capacity with trans-splicing or overlapping vectors: A quantitative comparison
    • Duan D, Yue Y, Engelhardt JF. Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison. Mol Ther 4(4): 383-391 (2001).
    • (2001) Mol Ther , vol.4 , Issue.4 , pp. 383-391
    • Duan, D.1    Yue, Y.2    Engelhardt, J.F.3
  • 41
    • 27144509758 scopus 로고    scopus 로고
    • Current development of adeno-associated viral vectors
    • Romano G. Current development of adeno-associated viral vectors. Drug News Perspect 18(5): 311-316 (2005).
    • (2005) Drug News Perspect , vol.18 , Issue.5 , pp. 311-316
    • Romano, G.1
  • 42
    • 22544484533 scopus 로고    scopus 로고
    • Enhancing rAAV vector expression in the lung
    • Virella-Lowell I, Zusman B, Foust K, et al. Enhancing rAAV vector expression in the lung. J Gene Med 7(7): 842-50 (2005).
    • (2005) J Gene Med , vol.7 , Issue.7 , pp. 842-850
    • Virella-Lowell, I.1    Zusman, B.2    Foust, K.3
  • 43
    • 20044381100 scopus 로고    scopus 로고
    • A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia
    • Ostedgaard LS, Rokhlina T, Karp PH, et al. A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. Proc Natl Acad Sci USA 102(8): 2952-2957 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.8 , pp. 2952-2957
    • Ostedgaard, L.S.1    Rokhlina, T.2    Karp, P.H.3
  • 44
    • 34548730279 scopus 로고    scopus 로고
    • Sendai virus-mediated CFTR gene transfer to the airway epithelium
    • Ferrari S, Griesenbach U, Iida A, et al. Sendai virus-mediated CFTR gene transfer to the airway epithelium. Gene Ther 14(19): 1371-1379 (2007).
    • (2007) Gene Ther , vol.14 , Issue.19 , pp. 1371-1379
    • Ferrari, S.1    Griesenbach, U.2    Iida, A.3
  • 45
    • 37149014804 scopus 로고    scopus 로고
    • Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector
    • Sinn PL, Goreham-Voss JD, Arias AC, et al. Enhanced gene expression conferred by stepwise modification of a nonprimate lentiviral vector. Hum Gene Ther 18(12): 1244-1252 (2007).
    • (2007) Hum Gene Ther , vol.18 , Issue.12 , pp. 1244-1252
    • Sinn, P.L.1    Goreham-Voss, J.D.2    Arias, A.C.3
  • 46
    • 34247876190 scopus 로고    scopus 로고
    • Vectors for airway gene delivery
    • Davis PB, Cooper MJ. Vectors for airway gene delivery. AAPS J 9(1): E11-E17 (2007).
    • (2007) AAPS , vol.J 9 , Issue.1
    • Davis, P.B.1    Cooper, M.J.2
  • 47
    • 0035885441 scopus 로고    scopus 로고
    • Human α-defensin-1 (HNP-1) inhibits adenoviral infection in vitro
    • Bastian A, Schaefer H. Human α-defensin-1 (HNP-1) inhibits adenoviral infection in vitro. Regulat Peptides 101: 157-161 (2001).
    • (2001) Regulat Peptides , vol.101 , pp. 157-161
    • Bastian, A.1    Schaefer, H.2
  • 48
    • 13144283616 scopus 로고    scopus 로고
    • An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
    • Morsy MA, Gu M, Motzel S, et al. An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc Natl Acad Sci USA 95(14): 7866-7871 (1998).
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.14 , pp. 7866-7871
    • Morsy, M.A.1    Gu, M.2    Motzel, S.3
  • 49
    • 2542532276 scopus 로고    scopus 로고
    • Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation
    • Cormet-Boyaka E, Jablonsky M, Naren AP, et al. Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation. Proc Natl Acad Sci USA 101(21): 8221-8226 (2004).
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.21 , pp. 8221-8226
    • Cormet-Boyaka, E.1    Jablonsky, M.2    Naren, A.P.3
  • 50
    • 5644224818 scopus 로고    scopus 로고
    • Non-viral vectors in cystic fibrosis gene therapy: Progress and challenges
    • Montier T, Delépine P, Pichon C, et al. Non-viral vectors in cystic fibrosis gene therapy: progress and challenges. Trends Biotechnol 22(11):586-92 (2004).
    • (2004) Trends Biotechnol , vol.22 , Issue.11 , pp. 586-592
    • Montier, T.1    Delépine, P.2    Pichon, C.3
  • 51
    • 0036314791 scopus 로고    scopus 로고
    • Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction
    • Giangreco A, Reynolds SD, Stripp BR. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol 161: 173-182 (2002).
    • (2002) Am J Pathol , vol.161 , pp. 173-182
    • Giangreco, A.1    Reynolds, S.D.2    Stripp, B.R.3
  • 52
    • 20444397431 scopus 로고    scopus 로고
    • Identification of bronchioalveolar stem cells in normal lung and lung cancer
    • Kim CF, Jackson EL, Woolfenden AE, et al. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121: 823-835 (2005).
    • (2005) Cell , vol.121 , pp. 823-835
    • Kim, C.F.1    Jackson, E.L.2    Woolfenden, A.E.3
  • 53
    • 19944427214 scopus 로고    scopus 로고
    • Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: Potential therapy for cystic fibrosis
    • Wang G, Bunnell BA, Painter RG, et al. Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis. Proc Natl Acad Sci USA 102(1): 186-191 (2005).
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.1 , pp. 186-191
    • Wang, G.1    Bunnell, B.A.2    Painter, R.G.3
  • 55
    • 33746030309 scopus 로고    scopus 로고
    • Stem cells and cystic fibrosis
    • Conese M, Rejman J. Stem cells and cystic fibrosis. J Cystic Fibrosis 5: 141-143 (2006).
    • (2006) J Cystic Fibrosis , vol.5 , pp. 141-143
    • Conese, M.1    Rejman, J.2
  • 56
    • 34848821636 scopus 로고    scopus 로고
    • New pulmonary therapies for cystic fibrosis
    • Ratjen F. New pulmonary therapies for cystic fibrosis. Curr Opin Pulm Med 13(6): 541-546 (2007).
    • (2007) Curr Opin Pulm Med , vol.13 , Issue.6 , pp. 541-546
    • Ratjen, F.1
  • 57
    • 38949104082 scopus 로고    scopus 로고
    • How not to be seen: Immune-evasion strategies in gene therapy
    • Zaldumbide A, Hoeben RC. How not to be seen: immune-evasion strategies in gene therapy. Gene Ther 15(4): 239-246 (2008).
    • (2008) Gene Ther , vol.15 , Issue.4 , pp. 239-246
    • Zaldumbide, A.1    Hoeben, R.C.2
  • 58
    • 0006422025 scopus 로고    scopus 로고
    • The innate immune response of the respiratory epithelium
    • Diamond G, Legarda D, Ryan LK. The innate immune response of the respiratory epithelium. Immunol Rev 173: 27-38 (2000).
    • (2000) Immunol Rev , vol.173 , pp. 27-38
    • Diamond, G.1    Legarda, D.2    Ryan, L.K.3
  • 59
    • 0033067894 scopus 로고    scopus 로고
    • The toll-receptor family and control of innate immunity
    • Kopp EB, Medzhitov R. The toll-receptor family and control of innate immunity. Curr Opin Immunol 11: 13-18 (1999).
    • (1999) Curr Opin Immunol , vol.11 , pp. 13-18
    • Kopp, E.B.1    Medzhitov, R.2
  • 60
    • 46049120813 scopus 로고    scopus 로고
    • Toll-like receptors, transduction-effector pathways and disease diversity - evidence of an immunobiological paradigm explaining all human illness?
    • in press
    • Atkinson TJ. Toll-like receptors, transduction-effector pathways and disease diversity - evidence of an immunobiological paradigm explaining all human illness? Int Rev Immunol (2008) (in press).
    • (2008) Int Rev Immunol
    • Atkinson, T.J.1
  • 61
    • 33846259390 scopus 로고    scopus 로고
    • Role of Ca2+ in responses of airway epithelia to Pseudomonas aeruginosa, flagellin, ATP, and thapsigargin
    • Fu Z, Bettega K, Carroll S, et al. Role of Ca2+ in responses of airway epithelia to Pseudomonas aeruginosa, flagellin, ATP, and thapsigargin. Am J Physiol Lung Cell Mol Physiol 292(1): L353-64 (2007).
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , Issue.1
    • Fu, Z.1    Bettega, K.2    Carroll, S.3
  • 62
    • 2942544512 scopus 로고    scopus 로고
    • Toll-like receptors in normal and cystic fibrosis airway epithelial cells
    • Muir A, Soong G, Sokol S, et al. Toll-like receptors in normal and cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol 30(6): 777-783 (2004).
    • (2004) Am J Respir Cell Mol Biol , vol.30 , Issue.6 , pp. 777-783
    • Muir, A.1    Soong, G.2    Sokol, S.3
  • 63
    • 33646237805 scopus 로고    scopus 로고
    • Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatoryresponse toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells
    • Shuto T, Furuta T, Oba M, et al. Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatoryresponse toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells. FASEB J 20(6): 782-784 (2006).
    • (2006) FASEB J , vol.20 , Issue.6 , pp. 782-784
    • Shuto, T.1    Furuta, T.2    Oba, M.3
  • 64
    • 12444322678 scopus 로고    scopus 로고
    • TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
    • Greene CM, Carroll TP, Smith SG, et al. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol 174(3): 1638-1646 (2005).
    • (2005) J Immunol , vol.174 , Issue.3 , pp. 1638-1646
    • Greene, C.M.1    Carroll, T.P.2    Smith, S.G.3
  • 65
    • 16344389339 scopus 로고    scopus 로고
    • Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis
    • Hauber HP, Tulic MK, Tsicopoulos A, et al. Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis. Can Respir J 12(1): 13-18 (2005).
    • (2005) Can Respir J , vol.12 , Issue.1 , pp. 13-18
    • Hauber, H.P.1    Tulic, M.K.2    Tsicopoulos, A.3
  • 66
    • 34347247718 scopus 로고    scopus 로고
    • Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb
    • Yu ZY, McKay K, van Asperen P, et al. Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. J Gene Med 9(6):429-439 (2007).
    • (2007) J Gene Med , vol.9 , Issue.6 , pp. 429-439
    • Yu, Z.Y.1    McKay, K.2    van Asperen, P.3
  • 67
    • 33750010667 scopus 로고    scopus 로고
    • Gene therapy for cystic fibrosis lung disease: Current status and future perspectives
    • Rosenecker J, Huth S, Rudolph C. Gene therapy for cystic fibrosis lung disease: current status and future perspectives. Curr Opin Mol Ther 8(5): 439-445 (2006).
    • (2006) Curr Opin Mol Ther , vol.8 , Issue.5 , pp. 439-445
    • Rosenecker, J.1    Huth, S.2    Rudolph, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.