Adenoviral Gene Delivery Elicits Distinct Pulmonary-Associated T Helper Cell Responses to the Vector and to Its Transgene

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 685-693

  Van Ginkel, Frederik W ^a   McGhee, Jerry R ^a   Liu, Chongguang ^b   Simecka, Jerry W ^c   Yamamoto, Masafumi ^a   Frizzell, Raymond A ^b   Sorscher, Eric J ^a   Kiyono, Hiroshi ^a,d   Pascual, David W ^e  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH TEXAS   (United States)

^d OSAKA UNIVERSITY   (Japan)

^e MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; ANIMAL; ARTICLE; C57BL MOUSE; CELLULAR IMMUNITY; GENE THERAPY; GENE TRANSFER; GENE VECTOR; IMMUNOLOGY; LUNG; LUNG DISEASE; MALE; MOUSE; PATHOLOGY; TH1 CELL; TH2 CELL;

ADENOVIRIDAE; ANIMALS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMMUNITY, CELLULAR; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; TH1 CELLS; TH2 CELLS;

EID: 0031570890     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Rosenfeld, M. A., K. Yoshimura, B. C. Trapnell, K. Yoneyama, E. R. Rosenthal, W. Dalemans, M. Fukayama, J. Bargon, L. E. Stier, L. Stratford-Perricaudet, M. Perricaudet, B. W. Guggino, A. Pavirani, J.-P. Lecocq, and R. G. Crystal. 1992. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68:143.
2. Zabner, J., L. A. Couture, R. J. Gregory, S. M. Graham, A. E. Smith, and M. J. Welsh. 1993. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75:1.
3. Jaffe, H.-A., C. Danel, G. Longenecker, M. Metzger, Y. Setoguchi, M. A. Rosenfeld, T. W. Gant, S. S. Thorgeirsson, L. D. Stratford-Perricaudet, and M. Perricaudet. 1992. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat. Genet. 1:372.
4. Kay, M. A., F. Graham, F. Leland, and S. L. Woo. 1995. Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology 21:815.
5. Yang, Y., H. C. Ertl, and J. M. Wilson. 1994. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1:433.
6. Yang, Y., Q. Li, H. C. Ertl, and J. M. Wilson. 1995. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004.
7. Ginsberg, H. S., L. L. Moldawer, P. B. Sehgal, M. Redington, P. L. Kilian, R. M. Chanock, and G. A. Prince. 1991. A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia. Proc. Natl. Acad. Sci. USA 88:1651.
8. Prince, G. A., D. D. Porter, A. B. Jenson, R. L. Horswood, R. M. Chanock, and H. S. Ginsberg. 1993. Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). J. Virol. 67:101.
9. Takafuji, E. T., J. C. Gaydos, R. G. Allen, and F. H. Top, Jr. 1979. Simultaneous administration of live, enteric coated adenovirus types 4, 7 and 21 vaccines: safety and immunogenicty. J. Infect. Dis. 140:48.
10. Ada, G. L., and R. V. Blanden. 1994. CTL immunity and cytokine regulation in viral infection. Res. Immunol. 145:625.
11. Riddell, S. R., and P. D. Greenberg. 1995. Principles of adoptive T cell therapy of human viral diseases. Annu. Rev. Immunol. 13:545.
12. Rawle, F. C., B. B. Knowles, R. P. Ricciardi, V. Brahmacheri, P. Duerksen-Hughes, W. S. M. Wold, and L. R. Gooding. 1991. Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5. J. Immunol. 146:3977.
13. Mullbacher, A., A. J. D. Bellett, and R. T. Hla. 1989. The murine cellular immune response to adenovirus type 5. Immunol. Cell Biol. 67:31.
14. Juillard, V., P. Villefroy, D. Godfrin, A. Pavirani, A. Venet, and J. G. Guillet. 1995. Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector. Eur. J. Immunol. 25:3467.
15. Yang, Y., F. A. Nunes, K. Berensci, E. E. Furth, E. Gonczol, and J. M. Wilson. 1994. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407.
16. Kolls, J. K., D. Lei, G. Odom, S. Nelson, W. R. Summer, M. A. Gerber, and J. E. Shellito. 1996. Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-depleted adenoviral vectors. Hum. Gene Ther. 7:489.
17. Yang, Y., G. Trinchieri, and J. M. Wilson. 1995. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1:890.
18. van Ginkel, F. W., C.-G. Liu, J. W. Simecka, J.-Y. Dong, T. Greenway, R. A. Frizzell, H. Kiyono, J. R. McGhee, and D. W Pascual. 1995. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and β-galactosidase. Hum. Gene Ther. 6:895.
19. Imler, J. L. 1995. Adenovirus vectors as recombinant viral vaccines. Vaccines 13:1143.
20. Gaydos, C. A., and J. C. Gaydos. 1995. Adenovirus vaccines in the U.S. military. Mil. Med. 160:300.
21. Both, G. W., L. J. Lockett, V. Janardhana, S. J. Edwards, A. R. Bellamy, F. L. Graham, L. Prevec, and M. E. Andrew. 1993. Protective immunity to rotavirus-induced diarrhea is passively transferred to newborn mice from naive dams vaccinated with a single dose of a recombinant adenovirus expressing rotavirus VP7sc. Virology 193:940.
22. Gallichan, W. S., D. C. Johnson, F. L. Graham, and K. L. Rosenthal. 1993. Mucosal immunity and protection after intranasal immunization with recombinant adenovirus expressing herpes simplex virus glycoprotein B. J. Infect. Dis. 168:622.
23. Gallichan, W. S., and K. L. Rosenthal. 1995. Specific secretory immune responses in the female genital tract following intranasal immunization with a recombinant adenovirus expressing glycoprotein B of herpes simplex virus. Vaccine 13:1589.
24. Xiang, Z. Q., Y. Yang, J. M. Wilson, and H. C. Ertl. 1996. A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier. Virology 219:220.
25. Zsengeller, Z.-K., S. E. Wert, W. M. Hull, X. Hu, S. Yei, B. C. Trapnell, and J. A. Whitsett. 1995. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nulnu) mice. Hum. Gene Ther. 6:457.
26. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
27. Xu-Amano, J., H. Kiyono, R. J. Jackson, H. F. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 in mucosu associated tissues. J. Exp. Med. 178:1309.
28. Marinaro, M., H. F. Staats, T. Hiroi, M. Coste, R. J. Jackson, P. N. Boyaka, N. Okahashi, M. Yamamoto, H. Kiyono, M. Bluethmann, K. Fujihashi, and J. R. McGhee. 1995. The mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. J. Immunol. 155:4621.
29. Kopf, M., G. L. Gross, M. Bachmann, M. C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362:245.
30. Kaufmann, S. H. E. 1995. Immunity to intracellular microbial pathogens. Immunol. Today 16:338.
31. Stevens, T. L. A., A. Bossie, V. M. Sanders, R. Fernandez-Botran, R. L. Coffman, T. R. Mosmann, and E. S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255.
32. Dong, J.-Y., D. Wang, F. W. van Ginkel, D. W. Pascual, and R. A. Frizzell. 1996. Systematic analysis of repeated gene delivery into animal lungs with recombinant adenovirus vector. Hum. Gene Ther. 7:319.
33. Maizel, J. V., Jr., D. O. White, and M. D. Scharff. 1968. The polypeptides of adenovirus. II. Soluble proteins, cores, top component and the structure of the virion. Virology 36:126.
34. Chardonnet, Y., J. Auray, and M. Lyon. 1970. Action of DEAE-dextran and of WR 1339 triton on cells in culture infected with adenovirus 5. C. R. Seances Soc. Biol. Fil. 164:1542.
35. Simecka, J. W., P. Patel, J. K. Davis, S. E. Ross, P. Otwell, and G. H. Cassell. 1991. Specific and nonspecific antibody responses in different segments of the respiratory tract in rats infected with Mycoplasma pulmonis. Infect. Immun. 59:3715.
36. Van Cott, J. L., H. F. Staats, D. W. Pascual, M. Roberts, S. N. Chatfield, M. Yamamoto, P. B. Carter, H. Kiyono, and J. R. McGhee. 1996. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. J. Immunol. 156:1504.
37. Yei, S., N. Mittereder, K. Tang, C. O'Sullivan, and B. C. Trapnell. 1994. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1:192.
38. Coutelier, J.-P., J. T. M. van der Voght, F. W. A. Heessen, G. Warnier, and J. van Snick. 1987. IgG2a restriction of murine antibodies elicited by viral infections. J. Exp. Med. 165:64.
39. Coutelier, J.-P., P. G. Coulie, P. Wauters, H. Heremans, and J. T. M. van der Loght. 1990. In vivo polyclonal B-lymphocyte activation elicited by murine viruses. J. Virol. 64:5383.
40. Mittal, S. K., M. R. McDermott, D. C. Johnson, L. Prevec, and F. L. Graham. 1993. Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Res. 28:67.
41. Setoguchi, Y., A. H. Jaffe, C.-S. Chu, and R. G. Crystal. 1994. Intraperitoneal in vivo gene therapy to deliver a 1-antitrypsin to the systemic circulation. Am. J. Respir. Cell Mol. Biol. 10:369.
42. Holt, P. G. 1993. Regulation of antigen-presenting cell function(s) in lung and airway tissues. Eur. Respir. J. 6:120.
43. Graham, F. L., and L. Prevec. 1992. Adenovirus-based expression vectors and recombinant vaccines. In Vaccines: New Approaches In Immunological Problems. R. W. Ellis, ed. Butterworth-Heinemann, Boston, p. 363.
44. Ayers, M. M., and P. K. Jeffery. 1988. Proliferation and differentiation in mammalian airway epithelium. Eur. Respir. J. 1:58.
45. Thaete, L. G., D. J. Ahnen, and A. M. Malkinson. 1989. Proliferating cell nuclear antigen (PCNA/cyclin) immunocytochemistry as a labeling index in mouse lung tissues. Cell Tissue Res. 256:167.
46. Barr, D., J. Tubb, D. Ferguson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, and M. A. Kay. 1995. Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2:151.
47. Yang, Y., Z. Xiang, E. C. Ertl, and J. M. Wilson. 1995. Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-medialed elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc. Natl. Acad. Sci. USA 92:7257.
48. Zsengeller, Z. K., S. E. Wert, W. M. Hull, X. Hu, S. Yei, B. C. Trapnell, and J. A. Whitsett. 1995. Persistence of replication-delicient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Hum. Gene Ther. 6:457.
49. Holt, P. G., A. Degebrodt, C. O'Leary, K. Krska, and T. Plozza. 1985. T cell activation by antigen-presenting cells from lung tissue digests: suppression by endogenous macrophages. Clin. Exp. Immunol. 62:586.
50. Kaltreider, H. B. 1984. Local immunity. In Immunology of the Lung and Upper Respiratory Tract. J. Bienenstock, ed. New York, McGraw-Hill, p. 191.
51. Bienenstock, J. 1984. The lung as an immunologic organ. Annu. Rev. Med. 35:49.