Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes

Biochemical Pharmacology

Volumn 73, Issue 11, 2007, Pages 1749-1757

  Aris, Sheena M ^a   Gewirtz, David A ^a   Ryan, John J ^a   Knott, Kenneth M ^b   Farrell, Nicholas P ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

A2780 human ovarian cancer cells; Apoptotic cell death; DNA strand breaks; Interstrand cross links; Transplatinum planar amine complexes

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CASPASE 3; CASPASE 9; FUNCTIONAL GROUP; HISTONE H2AX; ISOQUINOLINE DERIVATIVE; PLATINUM COMPLEX; PROTEIN P53; PYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL DEATH; CELL FUNCTION; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME MECHANISM; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; IC 50; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DEATH; CROSS-LINKING REAGENTS; DNA; DNA DAMAGE; FEMALE; HUMANS; ORGANOPLATINUM COMPOUNDS; OVARIAN NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 34247108134     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.02.013     Document Type: Article

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