Investigation of anti-tumor mechanisms of K2154: Characterization of tubulin isotypes, mitotic arrest and apoptotic machinery

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 374, Issue 3, 2006, Pages 223-233

  Lu, Pin Hsuan ^a   Kung, Fan Lu ^a   Kuo, Sheng Chu ^b   Chueh, Shih Chieh ^a   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bcl 2 family proteins; Caspase; Cdk1; Microtubule; Tubulin isotype

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; CASPASE 3; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR; ETHYL 2 [N 4 CHLOROBENZYL(2' METHOXY)]ANILINO 4 OXO 4,5 DIHYDROFURAN 3 CARBOXYLATE; GLYCOPROTEIN P; K 2154; MITOCHONDRIAL PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; ROSCOVITINE; THREONINE; TUBULIN; TYROSINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HT29; COLORECTAL CANCER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IMMUNOCHEMISTRY; INHIBITION KINETICS; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; MALE; MICROTUBULE; MITOSIS INHIBITION; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; SPINDLE CELL; STAINING; TURBIDITY; UPREGULATION;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B; CYTOCHROMES C; DRUG DELIVERY SYSTEMS; FURANS; HUMANS; INHIBITORY CONCENTRATION 50; MICROTUBULES; MITOCHONDRIA; MITOSIS; P-GLYCOPROTEIN; PHOSPHORYLATION; TUBULIN; UP-REGULATION;

EID: 33751427198     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-006-0114-x     Document Type: Article

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