Crystal Structure of allo-IleA2-Insulin, an Inactive Chiral Analogue: Implications for the Mechanism of Receptor Binding

Biochemistry

Volumn 42, Issue 44, 2003, Pages 12770-12783

  Wan, Zhu Li ^a   Xu, Bin ^a   Chu, Ying Chi ^b   Katsoyannis, Panayotis G ^b   Weiss, Michael A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE; PLASTICITY; PROTEINS;

RECEPTOR BINDING;

INSULIN;

ALLOISOLEUCINE; ALLOISOLEUCINE A2 INSULIN; DKP INSULIN; HORMONE RECEPTOR; INSULIN; INSULIN DERIVATIVE; ISOLEUCINE; MONOMER; UNCLASSIFIED DRUG; ZINC;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CHIRALITY; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; HYDROPHOBICITY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN VARIANT; PROTOMER; RECEPTOR BINDING; ROOT MEAN SQUARE DEVIATION; THERMODYNAMICS; X RAY DIFFRACTION;

BINDING SITES; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; HUMANS; INSULIN; ISOLEUCINE; LIGANDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECEPTOR, INSULIN; SOLUTIONS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

JIA;

EID: 0242675981     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034430o     Document Type: Article

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