Association of genetic variants of insulin degrading enzyme with metabolic features in women with polycystic ovary syndrome

Fertility and Sterility

Volumn 90, Issue 2, 2008, Pages 378-384

  Wang, Kehua ^a,b   You, Li ^a   Shi, Yuhua ^a   Wang, Laicheng ^a   Zhang, Meixin ^b   Chen, Zi Jiang ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Provincial Family Planning Institute of Science and Technology   (China)

Author keywords

gene; insulin resistance; insulin degrading enzyme; Polycystic ovary syndrome; single nucleotide polymorphism

Indexed keywords

INSULIN; INSULINASE;

ADULT; ALLELE; ARTICLE; BODY MASS; CASE CONTROL STUDY; CHINA; CLINICAL FEATURE; CONTROL GROUP; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; UNIVERSITY HOSPITAL; VEIN PUNCTURE;

ADULT; CASE-CONTROL STUDIES; CHINA; FEMALE; HUMANS; INSULYSIN; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES;

EID: 48149090532     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2007.06.016     Document Type: Article

References (37)

1. Frank S. Polycystic ovary syndrome. N Engl J Med 333 (1995) 853-861
2. Yen S.S.C. Polycystic ovary syndrome (hyperandrogenic chronic anovulation). In: Yen S.C.C., Jaffe R.B., and Barbieri R.L. (Eds). Reproductive endocrinology (1999), Saunders, Philadelphia 436-478
3. Asuncion M., Calvo R.M., San Millan J.L., Sancho J., Avila S., and Escobar Morreale H.F. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab 85 (2000) 2434-2438
4. Knochenhauer E.S., Key T.J., Kashar-Miller M., Waggoner W., Boots L.R., and Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the Southeastern United States: a prospective study. J Clin Endocrinol Metab 83 (1998) 3078-3082
5. Burghen G.A., Givens J.R., and Kitabchi A.E. Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab 50 (1980) 113-116
6. Chang R.J., Nakamura R.M., Judd H.L., and Kaplan S.A. Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57 (1983) 356-359
7. Dunaif A., Segal K.R., Futterweit W., and Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38 (1989) 1165-1174
8. Ehrmann D.A., Barnes R.B., Rosenfield R.L., Cavaghan M.K., and Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 22 (1999) 141-146
9. Legro R.S., Kunselman A.R., Dodson W.C., and Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84 (1999) 165-169
10. Waterworth D.M., Bennett S.T., Gharani N., McCarthy M.I., Hague S., Batty S., et al. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 349 (1997) 986-990
11. Bennett S.T., Todd J.A., Waterworth D.M., Franks S., and McCarthy M.I. Association of insulin gene VNTR polymorphism with polycystic ovary syndrome. Lancet 349 (1997) 1771-1772
12. Bennett S.T., and Todd J.A. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annu Rev Genet 30 (1996) 343-370
13. Huxtable S.J., Saker P.J., Haddad L., Walker M., Frayling T.M., Levy J.C., et al. Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles. Diabetes 49 (2000) 126-130
14. Duckworth W.C., Bennett R.G., and Hamel F.G. Insulin degradation: progress and potential. Endocrinol Rev 19 (1998) 608-624
15. Affholter J.A., Cascieri M.A., Bayne M.L., Brange J., Casaretto M., and Roth R.A. Identification of residues in the insulin molecule important for binding to insulin-degrading enzyme. Biochemistry 29 (1990) 7727-7733
16. Meigs J.B., Panhuysen C.I., Myers R.H., Wilson P.W., and Cupples L.A. A genomewide scan for loci linked to plasma levels of glucose and HbA1c in a community-based sample of Caucasian pedigrees: the Framingham Offspring Study. Diabetes 51 (2002) 833-840
17. Wiltshire S., Hattersley A.T., Hitman G.A., Walker M., Levy J.C., and Sampson M. A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69 (2001) 553-569
18. Ghosh S., Watanabe R.M., Valle T.T., Hauser E.R., Magnuson V.L., Langefeld C.D., et al. The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am J Hum Genet 67 (2000) 1174-1185
19. Duggirala R., Blangero J., Almasy L., Dyer T.D., Williams K.L., Leach R.J., et al. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am J Hum Genet 64 (1999) 1127-1140
20. Farris W., Mansourian S., Chang Y., Lindsley L., Eckman E.A., and Frosch M.P. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A 100 (2003) 4162-4167
21. Fakhrai-Rad H., Nikoshkov A., Kamel A., Fernstrom M., Zierath J.R., Norgren S., et al. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Hum Mol Genet 9 (2000) 2149-2158
22. Farris W., Mansourian S., Leissring M.A., Eckman E.A., Bertram L., Eckman C.B., et al. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol 164 (2004) 1425-1434
23. Groves C.J., Wiltshire S., Smedley D., Owen K.R., Frayling T.M., Walker M., et al. Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility. Diabetes 52 (2003) 1300-1305
24. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81 (2004) 19-25
25. Shi Y.Y., and He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res 15 (2005) 97-98
26. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrinol Rev 18 (1997) 774-800
27. San Millan J.L., Corton M., Villuendas G., Sancho J., Peral B., and Escobar Morreale H.F. Association of polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity. J Clin Endocrinol Metab 89 (2004) 2640-2646
28. Meigs J.B., Panhuysen C.I., Myers R.H., Wilson P.W., and Cupples L.A. A genome-wide scan for loci linked to plasma levels of glucose and HbA(1c) in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study. Diabetes 51 (2002) 833-840
29. Mulichak A.M., Wilson J.E., Padmanabhan K., and Garavito R.M. The structure of mammalian hexokinase-1. Nat Struct Biol 5 (1998) 555-560
30. Kim K.Y., Cho H.S., Jung W.H., Kim S.S., and Cheon H.G. Phosphatase and tensin homolog deleted on chromosome 10 suppression is an important process in peroxisome proliferator-activated receptor-{gamma} signaling in adipocytes and myotubes. Mol Pharmacol 71 (2007) 1554-1562
31. Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445 (2007) 881-885
32. Lehman D.M., Hunt K.J., Leach R.J., Hamlington J., Arya R., Abboud H.E., et al. Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes 56 (2007) 389-393
33. Grant S.F., Thorleifsson G., Reynisdottir I., Benediktsson R., Manolescu A., Sainz J., et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38 (2006) 320-323
34. Damcott C.M., Pollin T.I., Reinhart L.J., Ott S.H., Shen H., Silver K.D., et al. Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55 (2006) 2654-2659
35. Gu H.F., Efendic S., Nordman S., Ostenson C.G., Brismar K., Brookes A.J., et al. Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels. Diabetes 53 (2004) 2137-2142
36. Karamohamed S., Demissie S., Volcjak J., Liu C., Heard-Costa N., Liu J., et al. Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. Diabetes 52 (2003) 1562-1567
37. Florez J.C., Wiltshire S., Agapakis C.M., Burtt N.P., de Bakker P.I., Almgren P.B., et al. High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. Diabetes 55 (2006) 128-135