Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 1, 1999, Pages 165-169

  Legro, Richard S ^a   Kunselman, Allen R ^a   Dodson, William C ^a   Dunaif, Andrea ^b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNOLOGY; FEMALE; GLUCOSE INTOLERANCE; HIGH RISK POPULATION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SCREENING TEST;

ADOLESCENT; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; POLYCYSTIC OVARY SYNDROME; PREVALENCE; PROSPECTIVE STUDIES; RISK;

EID: 0032948363     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.1.165     Document Type: Article

References (45)

1. 1. Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. 1992 Polycystic ovary syndrome. Boston: Blackwell Scientific Publications, Inc.
2. 2. Franks S. 1995 Polycystic ovary syndrome. N Engl J Med. 333:853-861.
3. 3. Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R. 1998 Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 83:3078-3082.
4. 4. Hull MGR. 1987 Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol. 1:235-245.
5. 5. Burghen GA, Givens JR, Kitabchi AE. 1980 Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab. 50:113-116.
6. 6. Chang RJ, Nakamura RM, Judd HL, Kaplan SA. 1983 Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab. 57:356-359.
7. 7. Shoupe D, Kumar DD, Lobo RA. 1983 Insulin resistance in polycystic ovary syndrome. Am J Obstet Gynecol. 147:588-592.
8. 8. Pasquali R, Venturoli S, Paradis R, Capelli M, Parenti M, Melchionda N. 1982 Insulin and C-peptide levels in obese patients with polycystic ovaries. Horm Metab Res. 14 284-287.
9. 9. Dunaif A, Hoffman AR, Scully RE, et al. 1985 Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization. Obstet Gynecol. 66:545-552.
10. 10. Flier JS, Eastman RC, Minaker KL, Matteson D, Rowe JW. 1985 Acanthosis nigricans in obese women with hyperandrogenism. Characterization of an insulin-resistant state distinct from the type A and B syndromes. Diabetes. 34:101-107.
11. 11. Dunaif A, Segal KR, Futterweit W, Dobrjansky A. 1989 Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 38:1165-1174.
12. 12. Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T. 1992 Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes. 41:1257-1266.
13. 13. Ciaraldi TP, el-Roeiy A, Madar Z, Reichart D, Olefsky JM, Yen SSC. 1992 Cellular mechanisms of insulin resistance in polycystic ovarian syndrome. J Clin Endocrinol Metab. 75:577-583.
14. 14. Dunaif A, Xia J, Book CB, Schenker E, Tang Z. 1995 Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest. 96:801-810.
15. 15. Dunaif A. 1997 Insulin resistance and polycystic ovary syndrome: mechanisms and implications for pathogenesis. Endocr Rev. 18:774-800.
16. 16. Ek I, Arner P, Bergqvist A, Carlstrom K, Wahrenberg H. 1997 Impaired adipocyte lipolysis in nonobese women with the polycystic ovary syndrome: a possible link to insulin resistance? J Clin Endocrinol Metab. 82:1147-1153.
17. 17. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. 1990 Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med. 113:909-915.
18. 18. Reaven GM. 1988 Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 37:1595-1607.
19. 19. Lillioja S, Mott D, Spraul M, et al. 1993 Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. N Engl J Med. 329:1988-1992.
20. 20. O'Meara NM, Blackman JD, Ehrmann DA, et al. 1993 Defects in beta-cell function in functional ovarian hyperandrogenism. J Clin Endocrinol Metab. 76:1241-1247.
21. 21. Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonsky KS. 1995 Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest. 96:520-527.
22. 22. Dunaif A, Finegood DT. 1996 Beta-cell dysfunction independent of obesity, and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab. 81:942-947.
23. 23. Dunaif A, Graf M, Mandeli J, Laumas V, Dobrjansky A. 1987 Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. J Clin Endocrinol Metab. 65:499-507.
24. 24. Report of the Expert Committee on the Diagnosis, and Classification of Diabetes Mellitus. 1997 Diabetes Care. 20:1183-1197.
25. 25. Goodyear LJ, Kahn BB. 1998 Exercise, glucose transport, and insulin sensitivity. Annu Rev Med. 49:235-261.
26. 26. DeFronzo RA, Ferrannini E. 1991 Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 14:173-194.
27. 27. Eriksson J, Franssila-Kallunki A, Ekstrand A, et al. 1989 Early metabolic defects in persons at risk for noninsulin-dependent diabetes. N Engl J Med. 321:337-343.
28. 28. Dunaif A, Sorbara L, Delson R, Green G. 1993 Ethnicity and polycystic ovary syndrome are associated with independent and additive decreases in insulin action in Caribbean-Hispanic women. Diabetes. 42:1462-1468.
29. 29. Dunaif A, Scott D, Finegood D, Quintana B, Whitcomb R. 1996 The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J Clin Endocrinol Metab. 81:3299-3306.
30. 30. Modan M, Harris MI, Halkin H. 1989 Evaluation of WHO and NDDG criteria for impaired glucose tolerance. Results from two national samples. Diabetes. 38:1630-1635.
31. 31. Draper NR, Smith H. 1981 Applied regression analysis. 2nd ed. New York: John Wiley & Sons.
32. 32. Harris MI, Hadden WC, Knowler WC, Bennett PH. 1987 Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes. 36:523-534.
33. 33. Kjos SL, Peters RK, Xiang A, Henry OA, Montra M, Buchanan TA. 1995 Predicting future diabetes in Latino women with gestational diabetes. Utility of early postpartum glucose tolerance testing. Diabetes. 44:586-591.
34. 34. Harris MI, Flegal KM, Cowie CC, et al. 1998 Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. Diabetes Care. 21:518-524.
35. 35. Ehrmann DA, Rosenfield RL, Barnes RB, Karrison T. 1996 A longitudinal study of glucose tolerance in women with polycystic ovary syndrome. Prog 78th Annual Meeting of the Endocrine Society. Abstract OR 26-8.
36. 36. Haffner SM. 1995 Risk factors for non-insulin-dependent diabetes mellitus. J Hypertens Suppl. 13:S73-S76.
37. 37. Harris MI, Eastman RC, Cowie CC, Flegal KM, Eberhardt MS. 1997 Comparison of diabetes diagnostic categories in the U.S. population according to 1997 American Diabetes Association and 1980-1985 World Health Organization diagnostic criteria. Diabetes Care. 20:1859-1862.
38. 38. Burke JP, Haffner SM, Gaskill SP, Williams KL, Stern MP. 1998 Reversion from type 2 diabetes to nondiabetic status. Diabetes Care. 21:1266-1270.
39. 39. Knowler WC, Narayan KMV, Hanson RL, et al. 1995 Preventing non-insulin-dependent diabetes. Diabetes. 44:483-488.
40. 40. Keen H, Rose G, Pyke D, Boyns D, Chlouverakis C, Mistry S. 1965 Blood-sugar and arterial disease. Lancet. 2:505-508.
41. 41. Harris MI. 1989 Impaired glucose tolerance in the U.S. population. Diabetes Care. 12:464-474.
42. 42. DeFronzo RA. 1997 Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev. 5:177-269.
43. 43. Robinson S, Kiddy D, Gelding SV, et al. 1993 The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clin Endocrinol (Oxf). 39:351-355.
44. 44. Falsetti L, Eleftheriou G. 1996 Hyperinsulinemia in polycystic ovary syndrome - a clinical, endocrine, and echographic study of 240 patients. Gynecol Endocrinol. 10:319-326.
45. 45. Norman RJ, Mahabeer S, Masters S. 1995 Ethnic differences in insulin and glucose response between white and Indian women with polycystic ovary syndrome. Fertil Steril. 63:58-62.