Effect of dietary restriction and N-acetylcysteine supplementation on intestinal mucosa and liver mitochondrial redox status and function in aged rats

Experimental Gerontology

Volumn 39, Issue 9, 2004, Pages 1323-1332

  Grattagliano, Ignazio ^a   Portincasa, Piero ^a   Cocco, Tiziana ^a   Moschetta, Antonio ^a   Di Paola, Marco ^a   Palmieri, Vincenzo O ^a   Palasciano, Giuseppe ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Glutathione; Glutathione peroxidase; Intestinal transport; Mitochondrial respiration; Nitrosothiols; Protein sulfhydrils; Ussing chamber

Indexed keywords

ACETYLCYSTEINE; CARBONYL DERIVATIVE; GLUTATHIONE TRANSFERASE; NITRIC OXIDE; NITROSO DERIVATIVE; NITROSOTHIOL; PEROXIDASE; SUCCINIC ACID; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DIET SUPPLEMENTATION; ELECTRIC POTENTIAL; ENZYME ACTIVITY; ILEUM; ILEUM MUCOSA; INTESTINE ABSORPTION; INTESTINE MUCOSA; LIVER MITOCHONDRION; LOW CALORY DIET; MALE; MEMBRANE CURRENT; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN CONTENT; RAT;

ACETYLCYSTEINE; AGING; ANIMALS; CALORIC RESTRICTION; COLON; DIETARY SUPPLEMENTS; GLUTATHIONE; ILEUM; INTESTINAL MUCOSA; MALE; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; RATS; RATS, WISTAR;

EID: 5444240112     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2004.06.001     Document Type: Article

References (76)

1. Altomare E., Grattagliano I., Didonna D., Gentile A., Vendemiale G. Gastric and intestinal ethanol toxicity in the rat. Effect on glutathione level and role of alcohol and acetaldehyde metabolisms. Ital. J. Gastroenterol. Hepatol. 30:1998;82-90
2. Andrè M., Feley-Bosco E. Heme oxygenase-1 induction by endogenous nitric oxide: influence of intracellular glutathione. FEBS Lett. 546:2003;223-227
3. Augusteyn R.C. On the possible role of glutathione in maintaining human lens protein sulfhydryls. Exp. Eye Res. 28:1979;665-671
4. Ballatori N., Truong A.T. Relation between biliary glutathione excretion and bile acid-independent bile flow. Am. J. Physiol. 256:1989;G22-G30
5. Boscia F., Grattagliano I., Vendemiale G., Micelli-Ferrari T., Altomare E. Protein oxidation and lens opacity in humans. Invest. Ophthalmol. Vis. Sci. 41:2000;2461-2465
6. Braaten B., Madara J.L., Donowitz M. Age-related loss of nongoblet crypt cels parallels decreased secretion in rabbit descending colon. Am. J. Physiol. Gastrointest. Liver Physiol. 255:1988;G72-G84
7. Brookes P.S., Salinas E.P., Darley-Usmar K., Eiserich J.P., Freeman B.A., Darley-Usmar V.M., Anderson P.G. Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release. J. Biol. Chem. 275:2000;20474-20479
8. Brookes P.S., Levonen A.L., Shiva S., Sarti P., Darley-Usmar M. Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species. Free Radic. Biol. Med. 33:2002;755-764
9. Chen G., Wang S.H., Warner T.D. Regulation of iNOS mRNA levels in endothelial cells by glutathione, a double-edged sword. Free Radic. Biol. Med. 32:2000;223-234
10. Chiba T., Takahashi S., Sato N., Ishii S., Kikuchi K. Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells. Eur. J. Immunol. 26:1996;1164-1169
11. Clancy R.M., Levartovsky D., Leszczynska-Piziak J., Yegudin J., Abramson S.B. Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary. Proc. Natl Acad. Sci. USA. 91:1994;3680-3684
12. Clementi E., Brown G.C., Feelisch M., Moncada S. Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc. Natl Acad. Sci. USA. 95:1998;7631-7636
13. Cocco T., Cutecchia G., Montedoro G., Lorusso M. The antihypertensive drug carvedilol inhibits the activity of mitochondrial NADH-ubiquinone oxidoreductase. J. Bioenerg. Biomembr. 34:2002;251-258
14. Colell A., Garcia-Ruiz C., Miranda M., Ardite E., Mari M., Morales A., Corrales F., Kaplowitz N., Fernandez-Checa J.C. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology. 115:1998;1541-1551
15. Cook J.A., Kim S.Y., Teague D., Krishna M.C., Pacelli R., Mitchell J.B., Vodovotz Y., Nims R.W., Christodoulou D., Miles A.M., Grisham M.B., Wink D.A. Convenient colorimetric and fluorometric assays for S-nitrosothiols. Anal. Biochem. 238:1996;150-158
16. Devi B.G., Henderson G.I., Frosto T.A., Schanker S. Effect of ethanol on rat fetal hepatocytes: studies on cell replication, lipid peroxidation and glutathione. Hepatology. 18:1993;648-649
17. Ferraris R.P., Vinnakota R.R. Regulation of intestinal nutrient transport is impaired in aged mice. J. Nutr. 12:1993;502-511
18. Flohè L., Gunzler W.A. Assay of glutathione peroxidase. Methods Enzymol. 105:1984;114-121
19. Ghafourifar P., Richter C. Nitric oxide synthase activity in mitochondria. FEBS Lett. 418:1997;291-296
20. Ginn-Pease M.E., Whisler R.L. Optimal NF kappa B mediated transcriptional responses in Jurkat T cells exposed to oxidative stress are dependent on intracellular glutathione and costimulatory signals. Biochem. Biophys. Res. Commun. 226:1996;695-702
21. Giulivi C., Poderoso J.J., Boveris A. Production of nitric oxide by mitochondria. J. Biol. Chem. 273:1998;11038-11043
22. Glebska J., Skolimowski J., Kudzin Z., Gwozdzinski K., Grzelar A., Bartosz G. Pro-oxidative activity of nitroxides in their reaction with glutathione. Free Radic. Biol. Med. 35:2003;310-316
23. Goodell S., Cortopassi G. Analysis of oxygen consumption and mitochondrial permeability with age in mice. Mech. Ageing Dev. 101:1998;245-256
24. Goodrick C.L., Ingram D.K., Reynolds M.A., Freeman J.R., Cider N.L. Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats. J. Gerontol. 38:1983;36-45
25. Grattagliano I., Vendemiale G., Sabbà C., Buonamico P., Altomare E. Oxidation of circulating proteins in alcoholics: role of acetaldehyde and xanthine oxidase. J. Hepatol. 25:1996;28-36
26. Grattagliano I., Vendemiale G., Lauterburg B.H. Reperfusion injury of the liver: role of mitochondria and protection by glutathione ester. J. Surg. Res. 86:1999;2-8
27. Grattagliano I., Lauterburg B.H., Portincasa P., Caruso M.L., Vendemiale G., Valentini A.M., Palmieri V.O., Palasciano G. Mitochondrial glutathione content determines the rate of liver regeneration after partial hepatectomy in eu- and hypothyroid rats. J. Hepatol. 39:2003;571-579
28. Greenwood-Van Meerveld B., Tyler K., Keith J.C. Jr. Recombinant human interleukin-11 modulates ion transport and mucosal inflammation in the small intestine and colon. Lab. Invest. 80:2000;1269-1280
29. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpiridine. Anal. Biochem. 106:1980;207-212
30. 1 ATP synthase during aging. Possible involvement of oxygen free radicals. Ann. N.Y. Acad. Sci. 786:1996;62-71
31. Hagen T.M., Wierzbicka G.T., Bowman B.T., Aw T.Y., Jones D.P. Fate of dietary glutathione: disposition in the gastrointestinal tract. Am. J. Physiol. 259:1990;G530-G535
32. Hamilos D.L., Zelarney P., Mascali J.J. Lymphocyte proliferation in glutathione-depleted lymphocytes: direct relationship between glutathione availability and the proliferative response. Immunopharmacology. 18:1989;223-235
33. Harman D. Free radical theory of ageing. Mutat. Res. 275:1992;257-266
34. Huang Z.Z., Chen C., Zeng Z., Yang H., Oh J., Chen L., Lu S.C. Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regeneration. FASEB J. 15:2001;19-21
35. Iakova P., Awad S.S., Timchenko N.A. Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest. Cell. 113:2003;495-506
36. Ji Y., Akerboom T.P., Sies H., Thomas J.A. S. nitrosylation and S-glutathiolation of protein sulfhydryls by S-nitroso glutathione. Arch. Biochem. Biophys. 362:1999;67-78
37. Kamata H., Hirata H. Redox regulation of cellular signaling. Cell Signal. 11:1999;1-14
38. Kim Y.M., Talanian R.V., Billiar T.R. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272:1997;31138-31148
39. Lacza Z., Snipes J.A., Zhang J., Horvath E.M., Figueroa J.P., Szabò C., Busija D.W. Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS. Free Radic. Biol. Med. 35:2003;1217-1228
40. Levine R.L., Garland D., Oliver C.N., Amici A., Climent I., Lenz A.G., Ahn B.W., Shantiel S., Stadtman E.R. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:1990;464-478
41. Li J., Holbrook N.J. Common mechanisms for declines in oxidative stress tolerance and proliferation with aging. Free Radic. Biol. Med. 35:2003;199-292
42. Mannick J.A., Hausladen A., Liu L., Hess D.T., Zeng M., Miao Q.X., Kane L.S., Gow A.J., Stamler J.S. Fas-induced caspase denitrosylation. Science. 284:1999;651-654
43. Marin L., Aperia A. Colonic water and electrolyte transport in young and adult rats. J. Pediatr. Gastroenterol. Nutr. 3:1984;471-474
44. Martensson J., Jain A., Meister A. Glutathione is required for intestinal function. Proc. Natl Acad. Sci. USA. 87:1990;1715-1719
45. Martinez M., Hernadez H.I., Martinez N. N-Acetylcysteine delays age-associated memory impairment in mice: role of synaptic mitochondria. Brain Res. 855:2000;100-106
46. Mathews R., Kerr S.W. Biological activity of S-nitrosothiols: the role of nitric oxide. J. Pharmacol. Exp. Ther. 267:1993;1529-1537
47. McDougal J.N., Miller M.S., Burks T.F., Kreulen D.L. Age-related changes in colonic function in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 247:1984;G542-G546
48. Miquel J. An update on the mitochondrial-DNA mutation hypothesis of cell aging. Mutat. Res. 275:1992;209-216
49. Mirabelli F., Salis A., Marinoni V., Finardi G., Bellomo G., Thor H., Orrenius S. Menadione-induced bleb formation in hepatocytes is associated with the oxidation of thiol groups in actin. Arch. Biochem. Biophys. 264:1988;261-269
50. Morin D., Barthelemy S., Zini R., Labidalle S., Tillement J.P. Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation. FEBS Lett. 495:2001;131-136
51. - secretion induced by taurodeoxycholate from colon mucosa. Biol. Cell. 95:2003;115-122
52. Nagy I.Z., Ohta M., Kitani K., Cutler R.G. The effect of caloric restriction on the lateral diffusion of constant of hepatocyte membrane proteins in C57BL/6 male mice of different ages: FRAP studies on liver smears. Mech. Ageing Dev. 71:1993;85-96
53. Natale L., Piepoli A.L., De Salvia M.A., De Salvatore G., Mitolo C.I., Marzullo A., Portincasa P., Moschetta A., Palasciano G., Mitolo-Chieppa D. Interleukins 1 beta and 6 induce functional alteration of rat colonic motility: an in vitro study. Eur. J. Clin. Invest. 33:2003;704-712
54. Nicholls D.G. Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease. Int. J. Biochem. Cell Biol. 34:2002;1372-1381
55. Nishikawa M., Sato E.F., Kashiba M., Kuroki T., Utsumi K., Inoue M. Role of glutathione in nitric oxide-dependent regulation of energy metabolism in rat hepatoma cells. Hepatology. 27:1998;422-426
56. Nordberg J., Arner E.J.S. Reactive oxygen species, antioxidants, and the mammalian thioredoxin system. Free Radic. Biol. Med. 31:2001;1287-1312
57. Olafdottir K., Reed D.J. Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment. Biochim. Biophys. Acta. 964:1988;377-382
58. Orr W.C., Sohal R.S. Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science. 263:1994;1128-1130
59. Rebrin I., Kamzalov S., Sohal R.S. Effects of age and caloric restriction on glutathione redox state in mice. Free Radic. Biol. Med. 35:2003;626-635
60. Sandstrom O., Mahdavi J., El-Salhy M. Effect of ageing on colonic endocrine cell population in mouse. Gerontology. 44:1998;324-330
61. Schafer F.Q., Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic. Biol. Med. 30:2003;1191-1212
62. Schmucker D.L., Thoreux K., Owen R.L. Aging impairs intestinal immunity. Mech. Ageing Dev. 122:2001;1397-1411
63. Sies H. Glutathione and its role in cellular functions. Free Radic. Biol. Med. 27:1999;916-921
64. Stadtman E.R. Protein oxidation and aging. Science. 257:1992;1220-1224
65. Steffen M., Sarkela T.M., Gybina A.A., Steele T.W., Trasseth N.J., Kuehl D., Giulivi C. Metabolism of S-nitrosoglutathione in intact mitochondria. Biochem. J. 356:2001;395-402
66. Tanaka T., Yamashita T., Goto Y., Kondo K., Monna T., Nishiguchi S., Kuroki T., Otani S. Relationship between glutathione and polyamine metabolism after partial hepatectomy in alcohol-treated rats. Alcohol Clin. Exp. Res. 22:1998;125S-128S
67. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27:1969;502-522
68. Veeze H.J., Halley D.J., Bijman J., de Jongste J.C., de Jonge H.R., Sinaasappel M. Determinants of mild clinical symptoms in cystic fibrosis patients. Residual chloride secretion measured in rectal biopsies in relation to the genotype. J. Clin. Invest. 943:1994;461-466
69. Vendemiale G., Palmieri V., Palasciano G., Altomare E. Effect of glutathione administration on hepatic biliary and plasmatic glutathione levels in the rat. Scand. J. Gastroenterol. 29:1994;1034-1038
70. Ventura B., Genova M.L., Bovina C., Formiggini G., Lenaz G. Control of oxidative phosphorylation by Complex I in rat liver mitochondria: implications for aging. Biochim. Biophys. Acta. 1553:2002;249-260
71. Victor B.E., Schmidt K.L., Smith G.S., Miller T.A. Protection against ethanol injury in the canine stomach: role of mucosal glutathione. Am. J. Physiol. 261:1991;G966-G973
72. Wang L., Li J., Li Q., Zhang J., Duan X.L. Morphological changes of cell proliferation and apoptosis in rat jejunal mucosa at different ages. World J. Gastroenterol. 9:2003;2060-2064
73. Weindruch R., Sohal R.S. Caloric intake and aging. N. Engl. J. Med. 337:1997;986-994
74. Weindruch R., Walford R.L. Dietary restriction in mice beginning at 1 year of age: effect on life span and spontaneous cancer incidence. Science. 215:1982;1415-1418
75. Wieland P., Lauterburg B.H. Oxidation of mitochondrial proteins and DNA following administration of ethanol. Biochem. Biophys. Res. Commun. 213:1995;815-819
76. Youngman L.D., Park J.Y.K., Ames B.N. Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proc. Natl Acad. Sci. USA. 89:1992;9112-9116