Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity

Brain Research

Volumn 799, Issue 2, 1998, Pages 334-342

  Zheng, Wei ^a   Ren, Sean ^a   Graziano, Joseph H ^a  

^a The New York Presbyterian Hospital   (United States)

Author keywords

Aconitase; Iron; Manganese; Mitochondria; Parkinson's diseases; Respiratory chain

Indexed keywords

ACONITATE HYDRATASE; MANGANESE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; MALE; MITOCHONDRIAL RESPIRATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

ACONITATE HYDRATASE; ANIMALS; BRAIN; CITRIC ACID; DRUG INTERACTIONS; IRON; MANGANESE; MITOCHONDRIA; NEUROTOXINS; RATS;

EID: 0032551697     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00481-8     Document Type: Article

References (44)

1. M. Aschner, J.L. Aschner, Manganese transport across the blood-brain barrier: relationship to iron homeostasis, Brain Res. Bull. 24 (1996) 857-860.
2. A. Barbeau, N. Inoué, T. Cloutier, Role of manganese in dystonia, Adv. Neurol. 14 (1976) 339-352.
3. H. Beinert, M.C. Kennedy, Aconitase, a two-faced protein: enzyme and iron regulatory factor, FASEB J. 7 (1993) 1442-1449.
4. M.M. Bradford, A rapid and sensitive method for the quantification of microgram quantities of protein, Anal. Biochem. 72 (1976) 248-254.
5. A.C. Chua, E.H. Morgan, Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat, Biol. Trace Elem. Res. 55 (1996) 39-54.
6. J.B. Clark, W.J. Nicklas, The metabolism of rat brain mitochondria, J. Biol. Chem. 245 (1970) 4724-4731.
7. W.C. Cooper, The health implications of increased manganese in the environment resulting from the combustion of fuel additives: a review of the literature, J. Toxicol. Environ. Health 14 (1984) 23-46.
8. H.B. Ferraz, P.H.F. Bertolucci, J.S. Pereira, J.G.C. Lima, L.A.F. Andrade, Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication, Neurology 38 (1988) 550-553.
9. C.E. Gavin, K.K. Gunter, T.E. Gunter, Manganese and calcium efflux kinetics in brain mitochondria. Relevance to manganese toxicity, Biochem. J. 266 (1990) 329-334.
10. 2+ sequestration by mitochondria and inhibition of oxidative phosphorylation, Toxicol. Appl. Pharmacol. 115 (1992) 1-5.
11. C.E. Gavin, T.E. Gunter, Manganese dynamics in brain mitochondria, in: M. Yasui, M.J. Strong, K. Ota, M.A. Verity (Eds.), Mineral and Metal Neurotoxicology, CRC Press, New York, 1996, pp. 305-310.
12. B. Grafstein, D.S. Forman, Intracellular transport in neurons, Physiol. Rev. 60 (1980) 1167-1283.
13. C.P. Henson, W.W. Cleland, Purification and kinetic studies of beef liver cytoplasmic aconitase, J. Biol. Chem. 17 (1967) 3833-3838.
14. R.T. Ingersoll, E.B. Montgomery, H.V. Aposhian, Central nervous system toxicity of manganese. I. Inhibition of spontaneous motor activity in rats after intrathecal administration of manganese chloride, Fundam. Appl. Toxicol. 27 (1995) 106-113.
15. P. Jenner, A.H. Schapira, C.D. Marsden, New insights into the cause of Parkinson's disease, Neurology 42 (1992) 2241-2250.
16. M.C. Kennedy, M.H. Emptage, J.L. Dreyer, H. Beinert, The role of iron in the activation-inactivation of aconitase, J. Biol. Chem. 258 (1983) 11098-11105.
17. R.D. Klausner, T.A. Rouault, J.B. Harford, Regulating the fate of mRNA: The control of cellular iron metabolism, Cell 72 (1993) 19-28.
18. A.L. Koen, M. Goodman, Aconitase hydratase isozymes: subcellular location, tissue distribution and possible subunit structure, Biochim. Biophys. Acta 191 (1969) 698-701.
19. J.C. Lai, A.W. Chan, T.K. Leung, M.J. Minski, L. Lim, Neurochemical changes in rats chronically treated with a high concentration of manganese chloride, Neurochem. Res. 17 (1992) 841-847.
20. D.A. Loeffler, J.R. Connor, P.L. Juneau, B.S. Snyder, L. Kanaley, A.J. DeMaggio, H. Nguyen, C.M. Brickman, P.A. LeWitt, Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions, J. Neurochem. 65 (1995) 710-724.
21. S. Loranger, J. Zayed, Environmental and occupational exposure to manganese: a multimedia assessment, Int. Arch. Occup. Environ. Health 67 (1995) 101-110.
22. J.H. Martin (Ed.), Neuroanatomy, Appleton and Lange, Stamford, 1989, pp. 323-350.
23. I. Mena, J. Court, S. Fuenzalida, P.S. Papavasiliou, G.C. Cotzias, Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane, New Engl. J. Med. 282 (1970) 5-10.
24. J. Neve, N. Leclercq, Factors affecting determinations of manganese in serum by atomic absorption spectrometry, Clin. Chem. 37 (1991) 723-728.
25. E. Nieboer, G.G. Fletcher, Determinants of reactivity in metal toxicology, in: L.W. Chang (Ed.), Toxicology of Metals, CRC Press, New York, 1996, pp. 113-132.
26. C.W. Olanow, P.F. Good, H. Shinotoh, K.A. Hewitt, F. Vingerhoets, B.J. Snow, M.F. Beal, D.B. Calne, D.P. Perl, Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study, Neurology 46 (1996) 492-498.
27. A. Pentschew, F.F. Ebner, R.M. Kovatch, Experimental manganese encephalopathy in monkeys, J. Neuropathol. Exp. Neurol. 22 (1963) 488-499.
28. R.R. Ramsay, T.P. Singer, Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria, J. Biol. Chem. 261 (1986) 7585-7587.
29. A.H. Robbins, C.D. Stout, Iron-sulfur cluster in aconitase, crystallographic evidence for a three-iron center, J. Biol. Chem. 260 (1985) 2328-2333.
30. H. Roels, R. Lauwerys, J.P. Buchet, P. Genet, M.J. Sarhan, I. Hanotiau, M. deFays, A. Bernard, D. Stanescu, Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices, Am. J. Ind. Med. 11 (1987) 307-327.
31. P.A. Seligman, C. Chitambar, M. Vostrejs, P.L. Moran, The effects of various transferrins on iron utilization by proliferating cells, Ann. N.Y. Acad. Sci. 526 (1988) 136-140.
32. P.K. Seth, R. Husain, M. Mushtaq, S.V. Chandra, Effect of manganese on neonatal rat: Manganese concentration and enzymatic alterations in brain, Acta Pharmacol. Toxicol. 40 (1977) 553-560.
33. P.K. Seth, J.S. Hong, C.D. Kilts, S.C. Bondy, Alteration of cerebral neurotransmitter receptor function by exposure of rats to manganese, Toxicol. Lett. 9 (1981) 247-254.
34. P. Sierra, S. Loranger, G. Kennedy, J. Zayed, Occupational and environmental exposure of automobile mechanics and nonautomotive workers to airborne manganese arising from the combustion of methylcyclopentadienyl manganese tricarbonyl (MMT), Am. Ind. Hyg. Assoc. J. 56 (1995) 713-716.
35. J. Singh, R. Husain, S.K. Tandon, P.R. Seth, S.V. Chandra, Biochemical and histopathological alterations in early manganese toxicity in rats, Environ. Physiol. Biochem. 4 (1974) 16-23.
36. W.N. Sloot, A.J. Sluijs-Gelling, J.B.P. Gramsbergen, Selective lesions by manganese and extensive damage by iron after injection into rat striatum or hippocampus, J. Neurochem. 62 (1994) 205-216.
37. N.C. Sneed, J.L. Maynard, R.C. Brasted, Comprehensive Inorganic Chemistry, Nostrand, New York, 1953, pp. 68.
38. N. Suarez, H. Eriksson, Receptor-mediated endocytosis of a manganese complex of transferrin into neuroblastoma (SHSY5Y) cells in culture, J. Neurochem. 61 (1993) 127-131.
39. L.B. Tepper, Hazards to health: Manganese, New Engl. J. Med. 264 (1961) 347-348.
40. D.X. Wang, W.M. Zhou, S.Z. Wang, W. Zheng, Occupational exposure to manganese in welders and associated neurodegenerative diseases in China, Toxicol. Sci. 42 (1998) 24.
41. M. Yamada, S. Ohno, I. Okayasu, S. Hatakeyama, H. Watanabe, K. Ushio, H. Tsukagoshi, Chronic manganese poisoning: a neuropathological study with determination of manganese distribution in the brain, Acta Neuropathol. 70 (1986) 273-278.
42. M.B.H. Youdim, D. Ben-Shachar, P. Riederer, The possible role of iron in the etiopathology of Parkinson's disease, Mov. Disord. 8 (1993) 1-12.
43. W. Zheng, The choroid plexus and metal toxicities, in: L.W. Chang (Ed.), Toxicology of Metals, C.R.C. Press, New York, NY, 1996, pp. 605-622.
44. W. Zheng, D.F. Perry, D.L. Nelson, H.V. Aposhian, Protection of cerebrospinal fluid against toxic metals by the choroid plexus, FASEB J. 5 (1991) 2188-2193.