Combined effects of ammonia and manganese on astrocytes in culture

Neurochemical Research

Volumn 29, Issue 11 SPEC. ISS., 2004, Pages 2051-2056

  Jayakumar, A R ^a   Rao, K V Rama ^a   Kalaiselvi, P ^a   Norenberg, M D ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Ammonia; astrocyte; cell death; manganese; mitochondria; oxidative stress

Indexed keywords

ACETIC ACID; AMMONIA; ANTIOXIDANT; FREE RADICAL; LACTATE DEHYDROGENASE; MANGANESE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; MEMBRANE POTENTIAL; MICROSCOPY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMMONIA; ANIMALS; ASTROCYTES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DRUG SYNERGISM; FREE RADICALS; L-LACTATE DEHYDROGENASE; MANGANESE; MEMBRANE POTENTIALS; RATS;

ANIMALIA;

EID: 10844274031     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-004-6878-9     Document Type: Article

References (44)

1. Jones, E. A. and Weissenborn, K. 1997. Neurology and the liver. J. Neurol. Neurosurg. Psychiatry 63:279-293.
2. Norenberg, M. D. 1987. The role of astrocytes in hepatic encephalopathy. Neurochem. Pathol. 6:13-33.
3. Norenberg, M. D. 1981. The astrocyte in liver disease. Pages 303-352, in Fedoroff, S. and Hertz, L. (eds.), Advances in Cellular Neurobiology. New York: Academic Press.
4. Hazell, A. S. and Butterworth, R. F. 1999. Hepatic encephalopathy: An update of pathophysiologic mechanisms. Proc. Soc. Exp. Biol. Med. 222:99-112.
5. Krieger, D., Krieger, S., Jansen, O., Gass, P., Theilmann, L., and Lichtnecker, H. 1995. Manganese and chronic hepatic encephalopathy. Lancet 346:270-274.
6. Spahr, L., Butterworth, R. F., Fontaine, S., Bui, L., Therrien, G., Milette, P. C., Lebrun, L. H., Zayed, J., Leblanc, A., and Pomier-Layrargues, G. 1996. Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Hepatology 24:1116-1120.
7. Underwood, E. J. 1981. Trace metals in human and animal health. J. Hum. Nutr. 35:37-48.
8. Calne, D. B., Chu, N. S., Huang, C. C., Lu, C. S., and Olanow, W. 1994. Manganism and idiopathic parkinsonism: Similarities and differences. Neurology 44:1583-1586.
9. Pal, K. P., Samii, A., and Clane, D. B. 1999. Manganese neurotoxicity: A review of clinical features, imaging and pathology. Neurotoxicology 20:227-238.
10. Kaiser, J. 2003. State court to rule on manganese fume claims. Science 300:927.
11. Kaiser, J. 2003. Manganese: A high-octane dispute. Science 303:926-928.
12. Huang, C. C., Lu, C. S., Chu, N. S., Hochberg, F., Lilienfeld, D., Olanow, W., and Calne, D. B. 1993. Progress after chronic manganese exposure. Neurology 43:1479-1483.
13. Olanow, C. W., Good, P. F., Shinotoh, H., Hewitt, K. A., Vingerhoets, F., Snow, B. J., Beal, M. F., Calne, D. B., and Perl, D. P. 1996. Manganese intoxication in the rhesus monkey: A clinical imaging pathologic and biochemical study. Neurology, 46:492-498.
14. Hauser, R. A., Zesiewicz, T. A., Rosemurgy, A. S., Martinez, C., and Olanow, C. W. 1994. Manganese intoxication and chronic liver failure. Ann. Neurol. 36:871-875.
15. Hauser, R. A., Zesiewicz, T. A., Martinez, C., Rosemurgy, A. S., and Olanow, C. W. 1996. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can. J. Neurol. Sci. 23:95-98.
16. Sassine, M. P., Mergler, D., Bowler, R., and Hudnell, H. K. 2002. Manganese accentuates adverse mental health effects associated with alcohol use disorders. Biol. Psychiatry 51:909-921.
17. Rose, C., Butterworth, R. F., Zayed, J., Normandin, L., Todd, K., Michalak, A., Sphar, L., Huet, PM., and Pomier-Layrargues, G. 1999. Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology 117:640-644.
18. Papavasiliou, P. S., Miller, S. T., and Cotzias, G. C. 1966. Role of liver in regulating distribution and excretion of manganese. Am. J. Physiol. 211:211-216.
19. Desole, M. S., Esposito, G., Migheli, R., Fresu, L., Sircana, S., Zangani, D., Miele, M., and Miele, E. 1995. Cellular defence mechanisms in the striatum of young and aged rats subchronically exposed to manganese. Neuropharmacology 34:289-295.
20. Aschner, M. 1997. Manganese neurotoxicity and oxidative damage. Pages 77-93, in Connor, J. R. (ed.), Metal and Oxidative Damage in Neurological Disorders. New York: Plenum Press.
21. Worley, C. G., Bombick, D., Allen, J. W., Suber, R. L., and Aschner, M. 2002. Effects of manganese on oxidative stress in CATH.a cells. Neurotoxicology 23:159-164.
22. +3. Neurodegeneration 4:329-334.
23. Zhang, S., Fu, J., and Zhou, Z. 2004. In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain. Toxicology In Vitro 18:71-77.
24. Chen, C. J. and Liao, S. L. 2002. Oxidative stress involves in astrocytic alterations induced by manganese. Exp. Neurol. 175:216-225.
25. Tiffany-Castiglion, E. and Qian, Y. 2001. Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release. Neurotoxicology 22:577-592.
26. Rama Rao, K. V. and Norenberg, M. D. 2004. Manganese induces the mitochondrial permeability transition in cultured astrocytes. J. Biol. Chem. 279:32333-32338.
27. Murthy, Ch. R. K., Rama Rao, K. V., Bai, G., and Norenberg, M. D. 2001. Ammonia induced production of free radicals in primary cultures of rat astrocytes. J. Neurosci. Res. 66:282-288.
28. Bai, G., Rama Rao, K. V., Murthy, Ch. R. K., Panickar, K. S., Jayakumar, A. R., and Norenberg, M. D. 2001. Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes. J. Neurosci. Res. 66:981-991.
29. Thorburne, S. and Juurlink, B. H. 1996. Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress. J. Neurochem. 67:1014-1022.
30. Jayakumar, A. R., Rama Rao, K. V., Schousboe, A., and Norenberg, M. D. 2004. Glutamine-induced free radical production in cultured astrocytes. Glia 46:296-301.
31. Rama Rao, K. V., Jayakumar, A. R., and Norenberg, M. D. 2003. Ammonia neurotoxicity: Role of the mitochondrial permeability transition. Metab. Brain. Dis. 18:113-127.
32. Wroblewski, F. and LaDue, J. S. 1955. Lactic dehydrogenase activity in blood. Proc. Soc. Exp. Biol. Med. 90:210-213.
33. Hazell, A. S. and Norenberg, M. D. 1997. Manganese decreases glutamate uptake in cultured astrocytes. Neurochem. Res. 22:1443-1447.
34. Victor, M., Adams, R. D., and Cole, M. 1965. The acquired (non-Wilsonian) type of chronic hepatocerebral degeneration. Medicine 44:345-396.
35. Pomier-Layrargues, G., Spahr, L., and Butterworth, R. F. 1995. Increased manganese concentrations in pallidum of cirrhotic patients. Lancet 345:735.
36. Inoue, E., Hori, S., Narumi, I., Fujita, M., Kuriyama, K., Kadota, T., and Kuroda, C. 1991. Portal-systemic encephalopathy: Presence of basal ganglia lesions with high signal intensity on MR images. Radiology 179:551-555.
37. Pujol, A., Graus, F., Peri, J., Mercader, J. M., and Rimola, A. 1991. Hyperintensity in the globus pallidus on T1-weighted and inversion-recovery MRI: A possible marker of advanced liver disease. Neurology Sep;41(9):1526-1527.
38. Kulisevsky, J., Pujol, J., Balauzo, J., Junqué, C., Deus, J., Capdevilla, A., and Villanueva, C. 1992. Pallidal hyperintensity on magnetic resonance imaging in cirrhotic patients: Clinical correlations. Hepatology 16:1382-1388.
39. Gallez, B., Demeure, R., Baudelet, C., Abdelouahab, N., Beghein, N., Jordan, B., Geurts, M., and Roels, H. A. 2001. Non-invasive quantification of manganese deposits in the rat brain by local measurement of NMR proton T1 relaxation times. Neurotoxicology 22:387-392.
40. Liccione, J. J. and Maines, D. M. 1988. Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese. J. Pharmacol. Exp. Ther. 247:157-161.
41. 2 generation during neuromelanin synthesis. The action of manganese. Acta Med. Portug. 6:547-554.
42. Cohen, G., and Heikkila, R. E. 1974. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, manganese in synapses may be important to clarify the dialuric acid, and related cytotoxic agents. J. Biol. Chem. 249:2447-2452.
43. 2+ sequestration by mitochondria and inhibition of oxidative phosphorylation. Toxicol. Appl. Pharmacol. 115:1-5.
44. Zheng, W., Ren, S., and Graziano, J. H. 1998. Manganese inhibits mitochondrial aconitase: Mechanism of manganese neurotoxicity. Brain Res. 799:334-342.