The quest for Factor VIIa exosite inhibitors

Biochemical Society Transactions

Volumn 35, Issue 3, 2007, Pages 555-558

  Amour, A ^a   Hutchinson, J ^a   Ruiz Avendano A M ^b   Ratcliffe, S ^a   Alvarez, E ^b   Martin, J ^b   Toomey, J R ^c   Senger, S ^a   Wolfendale, M ^a   Mooney, C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b GLAXOSMITHKLINE   (Spain)

^c GLAXOSMITHKLINE   (United States)

Author keywords

Coagulation; Exosite inhibitor; Factor VII VIIa; Factor X Xa; Fluorescence polarization; High throughput screening

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 7A INHIBITOR;

CONFERENCE PAPER; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVITY; FLUORESCENCE POLARIZATION; PRIORITY JOURNAL; PROTEIN BINDING;

ALLOSTERIC REGULATION; BINDING SITES; DRUG EVALUATION, PRECLINICAL; FACTOR VIIA; FACTOR X; FLUORESCENCE POLARIZATION; HUMANS; KINETICS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; THROMBOPLASTIN;

EID: 34250889433     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0350555     Document Type: Conference Paper

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