Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): Classification as a metzincin

Biochemical Journal

Volumn 358, Issue 2, 2001, Pages 359-367

  Boldt, H B ^a   Overgaard, M T ^a   Laursen, L S ^a   Weyer, K ^a   Sottrup Jensen, L ^a   Oxvig, C ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Autocleavage; IGF; Insulin like growth factor binding protein; Metalloproteinase; Pappalysin

Indexed keywords

ANTIGENS; INSULIN; MUTAGENESIS; PROTEINS; SUBSTRATES; ZINC;

PROTEOLYTIC CLEAVAGE;

BIOCHEMISTRY;

ALANINE; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; METALLOPROTEINASE; METHIONINE; METZINCIN; PREGNANCY ASSOCIATED PLASMA PROTEIN A; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN C; UNCLASSIFIED DRUG; ZINC DERIVATIVE;

ANTIGENICITY; ARTICLE; BINDING AFFINITY; BIOAVAILABILITY; CELL ACTIVITY; CONTROLLED STUDY; ENZYME ACTIVE SITE; GENE DELETION; HUMAN; HUMAN CELL; MAMMAL CELL; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; STEREOCHEMISTRY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CELL LINE; DNA MUTATIONAL ANALYSIS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 4; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PREGNANCY-ASSOCIATED PLASMA PROTEIN-A; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; ZINC;

EID: 0035447508     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3580359     Document Type: Article

References (44)

1. Characterization of four human pregnancy-associated plasma proteins
2. Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA
3. The metzincins - Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases
4. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A
5. Zinc coordination, function, and structure of zinc enzymes and other proteins
6. Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'
7. Insulin-like growth factors and their binding proteins: Biological actions
8. The insulin-like growth factor-binding protein (IGFBP) superfamily
9. Posttranslational regulation of insulin-like growth factor binding protein-4 in normal and transformed human fibroblasts. Insulin-like growth factor dependence and biological studies
10. Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease
11. Evidence that the insulin-like growth factor binding protein-4 protease in human ovarian follicular fluid is pregnancy associated plasma protein-A
12. Insulin-like growth factor binding protein-4 protease produced by smooth muscle cells increases in the coronary artery after angioplasty
13. Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor
14. Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein
15. Isolation and characterization of circulating complex between human pregnancy-associated plasma protein-A and proform of eosinophil major basic protein
16. Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta
17. Biochemical properties, activities, and presence in biologic fluids of eosinophil granule major basic protein
18. Pregnancy-associated plasma protein-A2 (PAPP-A2) a novel insulin-like growth factor binding protein-5 proteinase
19. Pregnancy-associated plasma protein-E (PAPP-E)
20. Evaluation and improvement of multiple sequence methods for protein secondary structure prediction
21. Application of multiple sequence alignment profiles to improve protein secondary structure prediction
22. Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: Expression in human reproductive and nonreproductive tissues
23. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system
24. Production of high-titer helper-free retroviruses by transient transfection
25. 131I-labelled human growth hormone of high specific radioactivity
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Double-monoclonal immunofluorometric assays for pregnancy-associated plasma protein A/proeosinophil major basic protein (PAPP-A/proMBP) complex in first-trimester maternal serum screening for Down syndrome
28. The proform of eosinophil major basic protein: A new maternal serum marker for Down syndrome
29. A low-pH reverse-phase high-performance liquid chromatography system for analysis of the phenylthiohydantoins of S-carboxymethylcysteine and S-carboxyamidomethylcysteine
30. Structure of astacin with a transition-state analogue inhibitor
31. An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides
32. Structural basis for the action of thermolysin and reared zinc peptidases
33. Carboxypeptidase A
34. The role of histidine 231 in thermolysin-like enzymes. A site-directed mutagenesis study
35. Binding to thermolysin of phenolate-containing inhibitors necessitates a revised mechanism of catalysis
36. Kinetic characterization of the serralysins: A divergent catalytic mechanism pertaining to astacin-type metalloproteases
37. Site-directed mutagenesis of the active site glutamate in human matrilysin: Investigation of its role in catalysis
38. Families of metalloendopeptidases and their relationships
39. The metzincin-superfamily of zinc-peptidases
40. The roles of Glu93 and Tyr149 in astacin-like zinc peptidases
41. Cleavage analysis of insulin-like growth factor (IGF)-dependent IGF-binding protein-4 proteolysis and expression of protease-resistant IGF-binding protein-4 mutants
42. Studies on human pregnancy-induced insulin-like growth factor (IGF)-binding protein-4 proteases in serum: Determination of IGF-II dependency and localization of cleavage site
43. Autolytic activation of recombinant human 72 kilodalton type IV collagenase
44. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo