Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester

Biochemistry

Volumn 47, Issue 29, 2008, Pages 7734-7743

  Brandt, Gabriel S ^a   Nemeria, Natalia ^b   Chakraborty, Sumit ^b   McLeish, Michael J ^c   Yep, Alejandra ^c   Kenyon, George L ^c   Petsko, Gregory A ^a   Jordan, Frank ^b   Ringe, Dagmar ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTERS; ORGANIC COMPOUNDS;

ACTIVE CENTERS; BENZALDEHYDE (BA); METHYL ESTERS; THIAMIN DIPHOSPHATE (THDP);

ALDEHYDES;

AROMATIC AMINO ACID; BENZALDEHYDE; BENZOIN; BENZOYLPHOSPHONIC ACID METHYL ESTER; COCARBOXYLASE; HISTIDINE; LYASE; MAGNESIUM; PHENYLGLYOXYLIC ACID; PHOSPHONIC ACID DERIVATIVE; PYROPHOSPHATE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYST; COMPLEX FORMATION; COVALENT BOND; DECARBOXYLATION; ELECTRICITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; OPTICAL RESOLUTION; PRIORITY JOURNAL; PROTEIN DATA BANK; PROTON TRANSPORT; REACTION ANALYSIS; SPECTROSCOPY; X RAY ANALYSIS;

ALDEHYDE-LYASES; BENZALDEHYDES; BENZOIN; BINDING SITES; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, MOLECULAR; SUBSTRATE SPECIFICITY; THIAMINE PYROPHOSPHATE;

EID: 47649132844     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi8004413     Document Type: Article

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