N5-CAIR mutase: Role of a CO2 binding site and substrate movement in catalysis

Biochemistry

Volumn 46, Issue 10, 2007, Pages 2842-2855

  Hoskins, Aaron A ^b   Morar, Mariya ^a   Kappock, T Joseph ^b   Mathews, Irimpan I ^a   Zaugg, Judith B ^b   Barder, Timothy E ^b   Peng, Paul ^b   Okamoto, Akimitsu ^b   Ealick, Steven E ^a   Stubbe, JoAnne ^b  

^a Department of Obstetrics Gynecology   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOIMIDAZOLE RIBONUCLEOTIDE (AIR); CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (CAIR); TAUTOMERS;

CARBON DIOXIDE; CATALYSIS; ESCHERICHIA COLI; PH EFFECTS; RATE CONSTANTS; SUBSTRATES;

ENZYME KINETICS;

4 NITROAMINOIMIDAZOLE RIBONUCLEOTIDE; AMIDE; AMINOIMIDAZOLE RIBONUCLEOTIDE; AROMATIC COMPOUND; CARBON DIOXIDE; CARBOXYIMINOIMIDAZOLE RIBONUCLEOTIDE; CARBOXYLIC ACID; HISTIDINE; IMIDAZOLE DERIVATIVE; METHYL GROUP; MUTANT PROTEIN; MUTASE; N5 CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE; RIBONUCLEOTIDE; RIBOSE 5 PHOSPHATE; UNCLASSIFIED DRUG; N(5) CARBOXYAMINOIMIDAZOLE RIBONUCLETIDE MUTASE; N(5)-CARBOXYAMINOIMIDAZOLE RIBONUCLETIDE MUTASE; RECOMBINANT PROTEIN;

ARTICLE; BIOTRANSFORMATION; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; HYDROPHOBICITY; ISOMER; NONHUMAN; PH; PRIORITY JOURNAL; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; WILD TYPE; X RAY CRYSTALLOGRAPHY; BINDING SITE; CATALYSIS; CHEMISTRY; DECARBOXYLATION; GENETICS; METABOLISM; PROTEIN CONFORMATION;

ESCHERICHIA COLI;

BINDING SITES; CARBON DIOXIDE; CATALYSIS; DECARBOXYLATION; ESCHERICHIA COLI; HISTIDINE; HYDROGEN-ION CONCENTRATION; INTRAMOLECULAR TRANSFERASES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 33947230529     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi602436g     Document Type: Article

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