Review on immunosenescence

Reviews in Clinical Gerontology

Volumn 17, Issue 3, 2007, Pages 161-169

  Ginaldi, Lia ^a   Mengoli, Lucia Paola ^a   De Martinis, Massimo ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNITY; AGING; EVOLUTION; HUMAN; IMMUNE DEFICIENCY; IMMUNITY; INFLAMMATION; INNATE IMMUNITY; REVIEW; SENESCENCE; T LYMPHOCYTE;

EID: 47549117730     PISSN: 09592598     EISSN: 14699036     Source Type: Journal    
DOI: 10.1017/S0959259808002487     Document Type: Review

References (83)

1. Burkle A, Caselli G, Franceschi C et al. Pathophysiology of ageing, longevity and age-related diseases. Immun Ageing 2007; 4:1-8.
2. The Italian Multicentric Study on Centenarians. Epidemiological and socioeconomic aspects of Italian centenarians. Arch Gerontol Geriat 1997; 25:149-57.
3. De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. Febs Lett 2005; 579:2035-39.
4. Vasto S, Candore G, Balistreri CR et al. Inflammatory networks in ageing, age-related diseases and longevity. Mech Ageing Dev 2007; 128:83-91.
5. Cappola AR, Xue Q-L, Ferrucci L, Guralnik JM, Volpato S, Fried LP. Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women. J Clin Endocrinol Metab 2003; 88:2019-25.
6. Troen BR. The biology of aging. Mt Sinai J Med 2003; 70:3-22.
7. Hughes KA, Alipaz JA, Drnevich JM, Reynolds RM. A test of evolutionary theories of aging. Proc Natl Acad Sci 2002; 99:14286-91.
8. Rea IM. Ageing in the 21st century. Where to and how will we get there? Report on the 10th congress of the International Association of Biomedical Gerontology, the geriatrician's view. Exp Gerontol 2004; 39:283-84.
9. Ginaldi L, Sternberg H. The immune system. In: Timiras PS ed. Physiological basis of aging and geriatrics, fourth edition. Place? LLC Press, State ? USA, 2007; Chapter 14:231-48.
10. De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflammation markers predicting frailty and mortality in the elderly. Exp Mol Pathol 2006; 80:219-27.
11. Franceschi C, Capri M, Monti D et al. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128:92-105.
12. Franceschi C, Valensin S, Fagnoni F, Barbi C, Bonafè M. Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load. Exp Gerontol 1999; 34:911-21.
13. Appay V, Almeida JR, Sauce D, Autran B, Papagno L. Accelerated immune senescence and HIV-1 infection. Exp Gerontol 2007; 42:432-37.
14. Goronzy JJ, Fujii H, Weyand CM. Telomeres immune aging and autoimmunity. Exp Gerontol 2006; 41:246-51.
15. Witkowski JM, Soroczynska-Cybula M, Bryl E, Smolenska Z, Jozwik A. Klotho-a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes. J Immunol 2007; 178:771-77.
16. Pawelec G, Koch S, Guessmann H et al. Immunosenescence, suppression and tumour progression. Cancer Immunol Immunother 2006; 55:981-86.
17. Pawelec G., Larbi A. Immunity and ageing in man: Annual Review 2006/2007. Exp Gerontol 2008; 43:34-38.
18. Effros RB, Dagarag M, Valenzuela HF. In vitro senescence of immune cells. Exp Gerontol 2003; 38:1243-49.
19. Thewissen M, Somers V, Venken K et al. Analyses of immunosenescent markers in patients with autoimmune disease. Clin Immunol 2007; 123:209-18.
20. Effros RB. Telomerase induction in T cells: a cure for aging and disease? Exp Gerontol 2007; 42:416-20.
21. Koch S, Solona R, De la Rosa O, Pawelec G. Human cytomegalovirus infection and T-cell immunosenescence: a mini review. Mech Ageing Dev 2006; 127:538-43.
22. Vukmanovic-Stejic M, Zhang Y, CooK JE et al. Human CD4 +CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 2006; 116:2423-33.
23. Wolf D, Rumpold H, Koppelstatter C et al. Telomere length of in vivo expended CD4+ CD25+ regulatory T-cells is preserved in cancer patients. Cancer Immunol Immunother 2006; 55:1198-2008.
24. Ouyang Q, Wagner WM, Wikby A et al. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 2003; 23:247-57.
25. Franceschi C, Bonafè M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 2000; 18:1717-20.
26. Ouyang Q, Wagner WM, Voehringer D et al. Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer-cell lectin-like receptor G1 (KLRG1). Exp Gerontol 2003; 38:911-20.
27. Wenberger B, Lazuardi L, Weiskirchner I et al. Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. Hum Immunol 2007; 68:86-90.
28. Pourgheysori B, Khan N, Best D, Bruton R, Nayak L, Moss PA. The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire. J Virol 2007; 81:7759-65.
29. Van Leeuwen EM, Koning JJ, Remmerswaal EB, van Boarle D, van Lier RA, ten Berge IJ. Differential usage of cellular niches by cytomegalovirus versus EBV-and influenza virus-specific CD8+ T cells. J Immunol 2006; 177:4998-5005.
30. Zhang X, Fujii H, Kishimoto H, LeRoy E, Surh CD, Sprent J. Aging leads to disturbed homeostasis of memory phenotype CD8+ cells. J Exp Med 2002; 195:283-93.
31. Schmaltz HN, Fried LP, Xue QL et al. Chronic cytomegalovirus infection and inflammation are associated with prevalent frailty in community-dwelling older women. J Am Geriatr Soc 2005; 53:747-54.
32. Wikby A, Nilsson BO, Forsey R et al. The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late-life functioning. Mech Ageing Dev 2006; 127:695-04.
33. Hadrup SR, Kollgard T, Saremet T et al. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly. J Immunol 2006; 176:2645-53.
34. Hollegaard MV, Bidwell JL. Cytokine gene polymer phism in human disease: on-line databases. Genes Immun 2006; S37:269-76.
35. Licastro F, Candore G, Lio D et al. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immun Ageing 2005; 2:8-13.
36. Bonafè M, Olivieri F, Cavallone L et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 2001; 31:2357-61.
37. Olivieri F, Bonafè M, Giovagnetti S et al. In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging. Mech Ageing Dev 2003; 124:549-53.
38. Bruunsgaard H, Andersen-Ramberg K, Jeune B et al. A high plasma concentration of TNF-α is associated with dementia in centenarians. J Gerontol 1999; 54:357-64.
39. Franceschi C, Olivieri F, Marchegiani F et al. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech Ageing Dev 2005; 126:351-61.
40. Mannucci PM, Mari D, Merati G et al. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins. A study in centenarians. Arterioscler Thromb Vasc Biol 1997; 17:755-59.
41. Coppola R, Mari D, Lattuada A, Franceschi C. Von Willebrand factor in Italian centenarians. Hematologica 2003; 88:39-43.
42. Lio D, Scola L, Crivello A et al. Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-a-308 promoter SNP. J Med Genet 2002; 39:1-3.
43. Mariani E, Pulsatelli L, Neri S et al. RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects. Exp Gerontol 2002; 37:219-26.
44. Conboy IM, Randi TA. Aging, stem cells and tissue regeneration: lesson from muscle. Cell Cycle 2005; 4:407-10.
45. Conboy IM, Conboy MJ, Wagers AJ et al. Rejuvention of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433:760-64.
46. Bagnara GP, Bonsi L, Strippoli P et al. Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34 +cells to hemopoietic growth factors and remodeling of cytokine network. J Gerontol 2000; 55:61-66.
47. Moresi R, Tesei S, Costarelli L et al. Age- and gender-related alterations of the number and clonogenic capacity of circulating CD34 +progenitor cells. Biogerontology 2005; 6:185-92.
48. Candore G, Colonna-Romano G, Balistreri CR et al. Biology of longevity: role of the innate immune system. Rejuvenation Res 2006; 9:143-48.
49. Bonafe M, Salvioli B, Barbi C et al. The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ 2004; 11:962-73.
50. Salvioli S, Bonafe M, Barbi C et al. P53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21 WAF1. Cell Cycle 2005; 4:1264-71.
51. Bonafe M, Olivieri F, Cavallone L et al. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur J Immunol 2001; 31:2357-61.
52. Bonfigli AR, Scrollo C, Cenerelli S et al. Plasminogen activator inhibitor-1 plasma level increases with age in subjects with the 4G allele at position-675 in the promoter region. Thromb Haemost 2004; 92:1164-65.
53. Cipriano C, Caruso C, Lio D et al. The 308 G/A polymorphism of TNF-α influences immunological parameters in old subjects affected by infectious diseases. Int J Immunigenet 2005; 32:13-18.
54. Franceschi C, Valensin S, Lescai F et al. Neuroinflammation and the genetics of Alzheimer's disease: the search for a proinflammatory phenotype. Aging Clin Exp Res 2001; 13:163-70.
55. Szmitko PE, Wang C-H, Weisel RD, de Almeida JR, Anderson TJ, Verma S. New markers of inflammation and endothelial cell activation. Circulation 2003; 108:1917-23.
56. Passeri G, Pini G, Troiano L et al. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab 2003; 88:5109-15.
57. Roubenoff R. Catabolism of aging: is it an inflammatory process? Curr Opin Clin Nutr Metab Care 2003; 6:295-99.
58. Barbieri M, Ferrucci L, Ragno E et al. Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab 2003; 284:481-87.
59. Licastro F, Grimaldi LME, Bonafè M et al. Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain. Neurobiol Aging 2003; 5831:1-6.
60. Abbatecola AM, Ferrucci L, Grella R et al. Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc 2004; 52:399-404.
61. Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121:187-201.
62. Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 2002; 37:445-53.
63. Caruso C, Lio D, Cavallone L, Franceshi C. Aging, longevity, inflammation and cancer. Ann NY Acad Sci 2004; 1028:1-13.
64. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001; 357:539-45.
65. Ginaldi L, Di Benedetto MC, De Martinis M. Osteoporosis inflammation and ageing. Immun Ageing 2005; 4:2-14.
66. Ginaldi L, De Martinis M, Monti D, Franceschi C. Chronic antigenic load and apoptosis in immunosenescence. Trends Immunol 2005; 26:79-84.
67. Capri M, Monti D, Salvioli S et al. Complexity of anti-immunosenescence strategies in humans. Artif Organs 2006; 30:730-42.
68. Ginaldi L, De Martinis M, Modesti M et al. Immunophenotypical changes of T lymphocytes in the elderly. Gerontology 2000; 46:242-48.
69. Andrew D, Aspinall R. IL-7 and not stem-cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J Immunol 2001; 166:1524-30.
70. Zhu X, Gui J, Dohkan J, Cheng L, Barnes PF, Su DM. Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involution. Aging Cell 2007; 6:663-72.
71. Fagnoni FF, Vescovini R, Passeri G et al. Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging. Blood 2000; 95:2860-8.
72. Ginaldi L, De Martinis M, D'Ostilio A et al. Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometryc analysis. Am J Hematol 2001; 67:63-72.
73. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol 2003; 38:5-11.
74. De Martinis M, Franceschi C, Monti D, Ginaldi L. Apoptosis remodeling in immunosenescence: implications for strategies to delay ageing. Curr Med Chem 2007; 14:1389-97.
75. Hayflick L. Living forever and dying in the attempt. Exp Gerontol 2003; 38:1231-41.
76. Effros RB. Replicative senescence of CD8 T cells: effect on human ageing. Exp Gerontol 2004; 39:517-24.
77. Ginaldi L, De Martinis M, Monti D, Franceschi C. The immune system in the elderly. Activation-induced and damage-induced apoptosis. Immunol Res 2004; 30:81-94.
78. Monti D, Salvioli S, Capri M et al. Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians. Mech Ageing Dev 2000; 121:239-50.
79. Gupta S. Tumor necrosis factor-A-induced apoptosis in T cells from aged humans: a role of TNFR-I and downstream signaling molecules. Exp Gerontol 2002; 37:293-99.
80. De Martinis M, Modesti M, Ginaldi L. Phenotypic and functional changes of circulating monocytes and polymorphonuclear leucocytes from elderly persons. Immunol Cell Biol 2004; 82:415-20.
81. Larbi A, Dupuis G, Khalil A, Douziech N, Fortin C, Fulip T. Differential role of lipid rafts in the function of CD4 +and CD8+ human T lymphocytes with aging. Cell Signal 2006; 18:1017-30.
82. Franceschi C, Bonafe M. Centenaries as a model for healthy aging. Biochem Soc Trans 2003; 31:457-61.
83. Cooper RS. Gene-environment interactions and the etiology of common complex disease. Ann Int Med 2003; 139:445-49.