Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 15, 2007, Pages 4191-4195

  Nie, Zhe ^a   Perretta, Carin ^a   Erickson, Philip ^a   Margosiak, Stephen ^a   Almassy, Robert ^a   Lu, Jia ^a   Averill, April ^a   Yager, Kraig M ^a   Chu, Shaosong ^a  

^a Polaris Pharmaceuticals Inc   (United States)

Author keywords

Anticancer; CK2

Indexed keywords

ANTINEOPLASTIC AGENT; CASEIN KINASE II; PROTEIN KINASE INHIBITOR; PYRAZOLO[1,5 A][1,3,5]TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; PROSTATE CANCER; STRUCTURE ANALYSIS;

BINDING SITES; CASEIN KINASE II; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS;

EID: 34347388601     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.041     Document Type: Article

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