IL-13 induces a bronchial epithelial phenotype that is profibrotic

Respiratory Research

Volumn 9, Issue , 2008, Pages

  Malavia, Nikita K ^a   Mih, Justin D ^a   Raub, Christopher B ^a   Dinh, Bao T ^a   George, Steven C ^a  

^a University of California at Irvine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; INTERLEUKIN 13; MUCIN; MUCIN 5AC; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; TUBULIN;

ARTICLE; BRONCHUS; CELL CULTURE; DOWN REGULATION; DRUG ADMINISTRATION; DRUG EFFECT; EPITHELIUM CELL; HUMAN; LUNG FIBROSIS; METABOLISM; PHENOTYPE; SECRETION; TIME;

BRONCHI; CELLS, CULTURED; COLLAGEN; DOWN-REGULATION; DRUG ADMINISTRATION SCHEDULE; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-13; MUCINS; PHENOTYPE; PULMONARY FIBROSIS; RECOMBINANT PROTEINS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA2; TUBULIN;

EID: 47149104279     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-9-27     Document Type: Article

References (55)

1. Cohn L, Elias JA, Chupp GL. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 2004, 22:789-815. 10.1146/annurev.immunol.22.012703.104716, 15032597.
2. Busse W, Elias J, Sheppard D, Banks-Schlegel S. Airway remodeling and repair. Am J Respir Crit Care Med 1999, 160(3):1035-1042.
3. Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: new insights. J Allergy Clin Immunol 2003, 111(2):215-25; quiz 226. 10.1067/mai.2003.128, 12589337.
4. Elias JA, Zhu Z, Chupp G, Homer RJ. Airway remodeling in asthma. J Clin Invest 1999, 104(8):1001-1006. 408860, 10525034, 10.1172/JCI8124.
5. Fixman ED, Stewart A, Martin JG. Basic mechanisms of development of airway structural changes in asthma. Eur Respir J 2007, 29(2):379-389. 10.1183/09031936.00053506, 17264325.
6. Homer RJ, Elias JA. Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology (Bethesda) 2005, 20:28-35.
7. James A. Airway remodeling in asthma. Curr Opin Pulm Med 2005, 11(1):1-6. 10.1097/01.mcp.0000146779.26339.d8, 15591881.
8. James AL, Maxwell PS, Pearce-Pinto G, Elliot JG, Carroll NG. The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. Am J Respir Crit Care Med 2002, 166(12 Pt 1):1590-1595. 10.1164/rccm.2108069, 12471074.
9. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med 2001, 164(10 Pt 2):S28-38.
10. Vignola AM, Gagliardo R, Siena A, Chiappara G, Bonsignore MR, Bousquet J, Bonsignore G. Airway remodeling in the pathogenesis of asthma. Curr Allergy Asthma Rep 2001, 1(2):108-115. 10.1007/s11882-001-0077-4, 11899292.
11. Davies DE, Holgate ST. Asthma: the importance of epithelial mesenchymal communication in pathogenesis. Inflammation and the airway epithelium in asthma. Int J Biochem Cell Biol 2002, 34(12):1520-1526. 10.1016/S1357-2725(02)00048-1, 12379273.
12. Knight DA, Holgate ST. The airway epithelium: structural and functional properties in health and disease. Respirology 2003, 8(4):432-446. 10.1046/j.1440-1843.2003.00493.x, 14708552.
13. Mullin JM. Epithelial barriers, compartmentation, and cancer. Sci STKE 2004, 2004(216):pe2.
14. Warburton D, Schwarz M, Tefft D, Flores-Delgado G, Anderson KD, Cardoso WV. The molecular basis of lung morphogenesis. Mech Dev 2000, 92(1):55-81. 10.1016/S0925-4773(99)00325-1, 10704888.
15. Hackett TL, Knight DA. The role of epithelial injury and repair in the origins of asthma. Curr Opin Allergy Clin Immunol 2007, 7(1):63-68.
16. Holgate ST. The inflammation-repair cycle in asthma: the pivotal role of the airway epithelium. Clin Exp Allergy 1998, 28 Suppl 5:97-103. 10.1046/j.1365-2222.1998.028s5097.x, 9988454.
17. Knight D. Epithelium-fibroblast interactions in response to airway inflammation. Immunol Cell Biol 2001, 79(2):160-164. 10.1046/j.1440-1711.2001.00988.x, 11264711.
18. Holgate ST, Davies DE, Puddicombe S, Richter A, Lackie P, Lordan J, Howarth P. Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma. Eur Respir J Suppl 2003, 44:24s-29s. 10.1183/09031936.03.00000803, 14582897.
19. Holgate ST, Holloway J, Wilson S, Bucchieri F, Puddicombe S, Davies DE. Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proc Am Thorac Soc 2004, 1(2):93-98. 10.1513/pats.2306034, 16113419.
20. Lazaar AL, Panettieri RA. Airway smooth muscle: a modulator of airway remodeling in asthma. J Allergy Clin Immunol 2005, 116(3):488-95; quiz 496. 10.1016/j.jaci.2005.06.030, 16159613.
21. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002, 8(8):885-889.
22. Laoukili J, Perret E, Willems T, Minty A, Parthoens E, Houcine O, Coste A, Jorissen M, Marano F, Caput D, Tournier F. IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells. J Clin Invest 2001, 108(12):1817-1824. 209466, 11748265.
23. Ordonez CL, Khashayar R, Wong HH, Ferrando R, Wu R, Hyde DM, Hotchkiss JA, Zhang Y, Novikov A, Dolganov G, Fahy JV. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001, 163(2):517-523.
24. Hancock A, Armstrong L, Gama R, Millar A. Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am J Respir Cell Mol Biol 1998, 18(1):60-65.
25. Noble PW, Homer RJ. Idiopathic pulmonary fibrosis: new insights into pathogenesis. Clin Chest Med 2004, 25(4):749-58, vii. 10.1016/j.ccm.2004.04.003, 15564020.
26. Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001, 134(2):136-151.
27. Gray TE, Guzman K, Davis CW, Abdullah LH, Nettesheim P. Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol 1996, 14(1):104-112.
28. Thompson HG, Mih JD, Krasieva TB, Tromberg BJ, George SC. Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasis. Am J Physiol Lung Cell Mol Physiol 2006, 291(6):L1277-85. 10.1152/ajplung.00057.2006, 16891397.
29. Tschumperlin DJ, Shively JD, Kikuchi T, Drazen JM. Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. Am J Respir Cell Mol Biol 2003, 28(2):142-149. 10.1165/rcmb.2002-0121OC, 12540481.
30. Atherton HC, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol Lung Cell Mol Physiol 2003, 285(3):L730-9.
31. Booth BW, Adler KB, Bonner JC, Tournier F, Martin LD. Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha. Am J Respir Cell Mol Biol 2001, 25(6):739-743.
32. Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, Davies DE. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 2001, 25(3):385-391.
33. Wen FQ, Liu XD, Terasaki Y, Fang QH, Kobayashi T, Abe S, Rennard SI. Interferon-gamma reduces interleukin-4- and interleukin-13-augmented transforming growth factor-beta2 production in human bronchial epithelial cells by targeting Smads. Chest 2003, 123(3 Suppl):372S-3S.
34. Agarwal A, Coleno ML, Wallace VP, Wu WY, Sun CH, Tromberg BJ, George SC. Two-photon laser scanning microscopy of epithelial cell-modulated collagen density in engineered human lung tissue. Tissue Eng 2001, 7(2):191-202. 10.1089/107632701300062813, 11304454.
35. Wong BJ, Wallace V, Coleno M, Benton HP, Tromberg BJ. Two-photon excitation laser scanning microscopy of human, porcine, and rabbit nasal septal cartilage. Tissue Eng 2001, 7(5):599-606. 10.1089/107632701753213219, 11694193.
36. Raub CB, Suresh V, Krasieva T, Lyubovitsky J, Mih JD, Putnam AJ, Tromberg BJ, George SC. Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophys J 2007, 92(6):2212-2222. 1861799, 17172303, 10.1529/biophysj.106.097998.
37. Zoumi A, Yeh A, Tromberg BJ. Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence. Proc Natl Acad Sci U S A 2002, 99(17):11014-11019. 123202, 12177437, 10.1073/pnas.172368799.
38. Redington AE. Fibrosis and airway remodelling. Clin Exp Allergy 2000, 30 Suppl 1:42-45. 10.1046/j.1365-2222.2000.00096.x, 10849474.
39. Roberts CR. Is asthma a fibrotic disease?. Chest 1995, 107(3 Suppl):111S-117S. 10.1378/chest.107.3_Supplement.111S, 7874987.
40. Keating DT, Sadlier DM, Patricelli A, Smith SM, Walls D, Egan JJ, Doran PP. Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells. Respir Res 2006, 7:114. 1569837, 16948840, 10.1186/1465-9921-7-114.
41. Batra V, Musani AI, Hastie AT, Khurana S, Carpenter KA, Zangrilli JG, Peters SP. Bronchoalveolar lavage fluid concentrations of transforming growth factor (TGF)-beta1, TGF-beta2, interleukin (IL)-4 and IL-13 after segmental allergen challenge and their effects on alpha-smooth muscle actin and collagen III synthesis by primary human lung fibroblasts. Clin Exp Allergy 2004, 34(3):437-444. 10.1111/j.1365-2222.2004.01885.x, 15005738.
42. Chu HW, Balzar S, Seedorf GJ, Westcott JY, Trudeau JB, Silkoff P, Wenzel SE. Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma. Am J Pathol 2004, 165(4):1097-1106. 1618635, 15466377.
43. Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA. IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2005, 174(4):2305-2313.
44. Walter DM, McIntire JJ, Berry G, McKenzie AN, Donaldson DD, DeKruyff RH, Umetsu DT. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J Immunol 2001, 167(8):4668-4675.
45. Allahverdian S, Harada N, Singhera GK, Knight DA, Dorscheid DR. Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF. Am J Respir Cell Mol Biol 2008, 38(2):153-160. 10.1165/rcmb.2007-0173OC, 17717322.
46. Suresh V, Mih JD, George SC. Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells. Am J Respir Cell Mol Biol 2007, 37(1):97-104. 10.1165/rcmb.2006-0419OC, 17347445.
47. Swartz MA, Tschumperlin DJ, Kamm RD, Drazen JM. Mechanical stress is communicated between different cell types to elicit matrix remodeling. Proc Natl Acad Sci U S A 2001, 98(11):6180-6185. 33442, 11353845, 10.1073/pnas.111133298.
48. Olman MA. Epithelial cell modulation of airway fibrosis in asthma. Am J Respir Cell Mol Biol 2003, 28(2):125-128. 10.1165/rcmb.F257, 12540477.
49. Williams RM, Zipfel WR, Webb WW. Interpreting second-harmonic generation images of collagen I fibrils. Biophys J 2005, 88(2):1377-1386. 1305140, 15533922, 10.1529/biophysj.104.047308.
50. Sheppard D. Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 2006, 3(5):413-417. 10.1513/pats.200601-008AW, 16799084.
51. Fine A, Goldstein RH. The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts. J Biol Chem 1987, 262(8):3897-3902.
52. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, Senior RM, Elias JA. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001, 194(6):809-821. 10.1084/jem.194.6.809, 11560996.
53. Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999, 103(6):779-788. 408149, 10079098, 10.1172/JCI5909.
54. Bayram H, Devalia JL, Khair OA, Abdelaziz MM, Sapsford RJ, Sagai M, Davies RJ. Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro. J Allergy Clin Immunol 1998, 102(5):771-782. 10.1016/S0091-6749(98)70017-X, 9819294.
55. Devalia JL, Bayram H, Abdelaziz MM, Sapsford RJ, Davies RJ. Differences between cytokine release from bronchial epithelial cells of asthmatic patients and non-asthmatic subjects: effect of exposure to diesel exhaust particles. Int Arch Allergy Immunol 1999, 118(2-4):437-439. 10.1159/000024157, 10224468.