Airway remodeling and repair

American Journal of Respiratory and Critical Care Medicine

Volumn 160, Issue 3, 1999, Pages 1035-1042

  Busse, William ^b   Elias, Jack ^b   Sheppard, Dean ^b   Banks Schlegel, Susan ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

METALLOPROTEINASE; MUCIN;

ASTHMA; CELLULAR IMMUNITY; CONFERENCE PAPER; DISEASE ACTIVITY; EOSINOPHIL; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMAN; LUNG FUNCTION; MAST CELL; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; TISSUE REPAIR;

EID: 0032844964     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.160.3.9902064     Document Type: Conference Paper

References (51)

1. Holgate, S. T. 1997. Asthma: a dynamic disease of inflammation and repair. In D. Chadwick and G. Cardow, editors. The Rising Trends in Asthma. Ciba Foundation Symposium 206, John Wiley and Sons, Chichester, UK. 5-34.
2. Beasley, R., W. R. Roche, J. A. Roberts, and S. T. Holgate. 1989. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am. Rev. Respir. Dis. 139:806-817.
3. Jeffrey, P. K., A. J. Wardlaw, F. C. Nelson, J. V. Collins, and A. B. Kay. 1989. Bronchial biopsies in asthma: an ultrastructural, quantitative study and correlation with hyperreactivity. Am. Rev. Respir. Dis. 140: 1743-1753.
4. Jeffrey, P. K., R. W. Godfrey, H. Ädelroth, F. Nelson, A. Rogers, and S.-A. Johansson. 1992. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopy study. Am. Rev. Respir. Dis. 145:890-899.
5. Peat, J. K., A. J. Woolcock, and K. Cullen. 1987. Rate of decline of lung function in subjects with asthma. Eur. J. Respir. Dis. 20:171-179.
6. Brown, P. J., H. W. Greville, and K. E. Finucane. 1984. Asthma and irreversible airflow obstruction. Thorax 39:131-136.
7. Wilson, J. W. 1998. What causes airway remodeling in asthma? Clin. Exp. Allergy 28:534-536.
8. Li, X., and J. W. Wilson. 1997. Increased vascularity of the bronchial mucosa in mild asthma. Am. J. Respir. Crit. Care Med. 156:229-233.
9. Roche, W. R. 1991. Fibroblasts and asthma. Clin. Exp. Allergy 21:545-548.
10. Brewster, L. E. P., P. H. Howarth, R. Djukanovic, J. Wilson, S. T. Holgate, and W. R. Roche. 1990. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am. J. Respir. Cell Mol. Biol. 3:507-511.
11. Cho, S. Y., J. Y. Seo, D. C. Choi, H. J. Yoon, Y. J. Cho, K. U. Min, G. K. Lee, J. W. Seo, and Y. Y. Kim. 1996. Pathological changes according to the severity of asthma. Clin. Exp. Allergy 26:1210-1219.
12. Chetta, A., A. Foresi, M. Del Donno, G. Bertorelli, A. Pesci, and D. Olivieri. 1997. Airway remodeling is a distinctive feature of asthma and is related to severity of asthma. Chest 111:852-857.
13. Chu, H. W., J. L. Halliday, R. J. Martin, D. Y. Leung, S. J. Szefler, and S. C. Wenzel. 1998. Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease. Am. J. Respir. Crit. Care Med. 111:852-857.
14. Laitinen A., A. Altraja, M. Kampe, M. Linden, I. Virtanen, and L. A. Laitinen. 1997. Tenascin is increased in airways basement membrane of asthmatics and decreased by an inhaled steroid. Am. J. Respir. Crit. Care Med. 156:951-958.
15. Bousquet, J., J. Y. Lacoste, P. Chanez, P. Vic, P. Godard, and F. B. Michel. 1996. Bronchial elastic fibers in normal subjects and asthmatic patients. Am. J. Respir. Crit. Care Med. 153:1648-1654.
16. Mautino, G., N. Oliver, P. Chanez, J. Bousquet, and F. Capony. 1997. Increase release of matrix metalloproteinase-9 in bronchoalveolar lavage fluid and by alveolar macrophages of asthmatics. Am. J. Respir. Cell Mol. Biol. 17:583-591.
17. Kraft, M., R. Djukanovic, S. Wilson, S. T. Holgate, and R. J. Martin. 1996. Alveolar tissue inflammation in asthma. Am. J. Respir. Crit. Care Med. 154:1505-1510.
18. Hynes, R. O. 1987. Integrins: a family of cell surface receptors. Cell 48: 549-554.
19. Sakai, T., Q. Zhang, R. Fassler, and D. F. Mosher. 1998. Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domain. J. Cell Biol. 141:527-538.
20. Phan, S. H. 1996. Role of the myofibroblast in pulmonary fibrosis. Kidney Int. 54:S46-S48.
21. Zhang, H. Y., M. Gharaee-Kermani, K. Zhang, S. Karmiol, and S. H. Phan. 1996. Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomyein-induced pulmonary fibrosis. Am. J. Pathol. 148:527-537.
22. Hynes, R. O. 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11-25.
23. Sheppard, D. 1996. Epithelial integrins. Bioassays 18:655-660.
24. Sheppard, D. 1998. Airway epithelial integrins: why so many? Am. J. Respir. Cell Mol. Biol. 19:349-351.
25. Huang, X. Z., J. F. Wu, D. Cass, D. J. Erle, D. Corry, S. G. Young, R. V. Farese, Jr., and D. Sheppard. 1996. Inactivation of the integrinβ6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J. Cell Biol. 133:921-928.
26. Munger, J., X. Z. Huang, H. Kawakatsu, M. J. D. Griffiths, S. D. Dalton, J. F. Wu, J. F. Pittet, N. Kaminiski, C. Garat, M. A. Matthay, D. B. Rifkin, and D. Sheppard. 1999. The integrin αvβ6 hinds and activates latent TGFβ1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96:319-328.
27. Madlener, M., W. C. Parks, and S. Werner. 1998. Matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) are differentially expressed during excisional skin wound repair. Exp. Cell Res. 242:201-210.
28. Taguchi, M., D. Sampath, T. Koga, M. Castro, D. C. Look, S. Nakajima, and M. J. Holtzman. 1995. Patterns for RANTES secretion and intercellular adhesion molecule 1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo. J. Exp. Med. 187:1927-1940.
29. Look, D. C., M. R. Pelletier, R. M. Tidwell, W. T. Roswit, and M. J. Holtzman. 1995. Statl depends on transcriptional synergy with Sp1. J. Biol. Chem. 270:30264-30267.
30. Li, J. D., W. Feng, M. Gallup, J. H. Kim, J. Gum, Y. Kim, and C. Basbaum. 1998. Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 95:5718-5723.
31. Bradding, P., A. E. Redington, and S. T. Holgate. 1997. Airway wall remodeling in the pathogenesis of asthma: cytokine expression in the airways. In A. G. Stewart, editor. Airway Wall Remodelling in Asthma-CRC Press, Inc., Boca Raton, FL. 29-63.
32. Dennler, S., S. Itoh, D. Vivien, P. ten Dijke, S. Huet, and J. M. Gauthier. 1998. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17:3091-3100.
33. Heldin, C. H., K. Miyazono, and P. ten Dijke. 1997. TGF-beta signalling from cell membrane to nucleus through SMAD proteins [Review]. Nature 390:465-471.
34. Cony, D. B., H. G. Folkesson, M. L. Warnock, D. J. Erle, M. A. Matthay, J. P. Wiener-Kronish, and R. M. Locksley. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109-117.
35. Foster, P. S., S. P. Hogan, A. J. Ramsay, K. I. Matthaei, and I. G. Young. 1996. Interleukin 5 deficiency abolishes cosinophilia, airways hyperre-activity, and lung damage in a mouse asthma model. J. Exp. Med. 183: 195-201.
36. Temann, U. A., B. Prasad, M. W. Gallup, C. Basbaum, S. B. Ho, R. A. Flavell, and J. A. Rankin. 1997. A novel role for murine IL-4 in vivo: induction of MU5AC gene expression and mucin hypersecretion. Am. J. Respir. Cell Mol. Biol. 16:471-478.
37. Lee, J. J., M. P. McGarry, S. C. Farmer, K. L. Denzler, K. A. Larson, P. E. Carrigan, I. E. Brenneise, M. A. Horton, A. Haczku, E. W. Gelfand, G. D. Leikauf, and N. A. Lee. 1997. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. J. Exp. Med. 185:2143-2156.
38. Temen, U.-A., G. P. Geba, J. A. Rankin, and R. A. Flavell, 1998. Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia and bronchial hyperresponsiveness. J. Exp. Med. 188:1307-1320.
39. Tang, W., G. P. Geba, T. Zheng, P. Ray, R. Homer, C. I. Kuhn, R. A. Favell, and J. A. Elias, 1996. Targeted expression of IL-11 in the murine airway causes airways obstruction, bronchial remodeling and lymphocytic inflammation. J. Clin. Invest. 98:2845-2853.
40. Betz, U. A. K., W. Bloch, M. van den Brock, K. Yoshida, T. Taga, T. Kishimoto, K. Addicks, K. Rajewsky, and W. Muller. 1998. Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J. Exp. Med. 188:1955-1965.
41. Ray, P., W. Tang, P. Wang, R. Homer, C. I. Kuhn, R. A. Flavell, and J. A. Elias. 1997. Regulated overexpression of interleukin-11 in the lung: use to dissociate development-dependent and -independent phenotypes. J. Clin. Invest. 100:2501-2511.
42. Anwar, A. R. F., R. Moqbel, G. M. Walsh, A. B. Kay, and A. J. Wardlaw. 1993. Adhesion to fibronectin prolongs eosinophil survival. J. Exp. Med. 177:839-843.
43. Inoue, Y., T. E. J. King, S. S. Tinkle, K. Dockstader, and L. S. Newman. 1996. Human mast cell basic fibroblast growth factor in pulmonary fibrotic disorders. Am. J. Pathol. 149:2037-2054.
44. Cairns, J. A., and A. F. Walls. 1997. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J. Clin. Invest. 99: 1313-1321.
45. Thurston, G., T. J. Murphy, P. Baluk, J. R. Lindsey, and D. M. McDonald. 1998. Angiogenesis in mice with chronic airway inflammation. Am. J. Pathol. 153:1099-1112.
46. Pare, P. D., C. R. Roberts, T. R. Bai, and B. J. Wiggs. 1997. The functional consequences of airway remodeling in asthma. Monaldi Arch. Chest Dis. 52:589-598.
47. Ebina, M., T. Takahashi, T. Chiba, and M. Motomjya. 1993. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am. Rev. Respir. Dis. 48: 720-726.
48. Pare, P. D., and T. R. Bai. 1996. Airway wall remodelling in chronic obstructive pulmonary disease. Eur. Respir. J. 6:259-263.
49. Panettieri, R. A. 1998. Cellular and molecular mechanisms regulating airway smooth muscle cell proliferation and cell adhesion molecule expression. Am. J. Respir. Crit. Care Med. 158:S133-S140.
50. Krymskaya, V. P., R. Hoffman, A. Eszterhas, V. Ciocca, and R. A. Panettieri. 1997. TGF-β1 modulates EGF-stimulated phosphtidylinositol 3-kinase activity in human airway smooth muscle cells. Am. J. Physiol. 273:L1220-L1227.
51. Panettieri, R. A., I. P. Hall, C. S. Maki, and R. K. Murray. 1995.α-Thrombin increases cytosolic calcium and induces human airway muscle cell proliferation. Am. J. Respir. Cell Mol. Biol. 13:205-216.