Airway remodeling in asthma

Current Opinion in Pulmonary Medicine

Volumn 11, Issue 1, 2005, Pages 1-6

  James, Alan ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

Author keywords

Asthma; Extracellular matrix; Fibroblast; Mitogenic stimuli; Smooth muscle

Indexed keywords

AIRWAY DYNAMICS; ARTERY WALL; ASTHMA; BREATHING MUSCLE; EOSINOPHIL; EXTRACELLULAR MATRIX; FIBROBLAST; HUMAN; INFLAMMATION; LUNG INJURY; LUNG MECHANICS; MAST CELL; MECHANICAL STRESS; MITOGENESIS; MORPHOLOGICAL ADAPTATION; NONHUMAN; RESPIRATORY EPITHELIUM; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 13244259205     PISSN: 10705287     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mcp.0000146779.26339.d8     Document Type: Review

References (60)

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51. Jongepier H, Boezen HM, Dijkstra A, et al.: Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma. Clin Exp Allergy 2004, 34:757-760. This Dutch study examined lung function data collected in 200 asthma patients over a 20-year period and showed that the rate of decline of lung function is related, in a small group of patients, to a polymorphism of the ADAM 33 gene, which may affect airway remodeling in asthma.
52. Mahut B, Delclaux C, Tillie-Leblond I, et al.: Both inflammation and remodeling influence nitric oxide output in children with refractory asthma. J Allergy Clin Immunol 2004, 113:252-256.
53. Cataldo DD, Gueders M, Munaut C, et al.: Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases mRNA transcripts in the bronchial secretions of asthmatics. Lab Invest 2004, 84:418-424. These investigators examined MMPs and TIMPs in the induced sputum of patients with asthma and compared them with those in sputum samples from nonasthmatic control cases. The expression of mRNA for MMP-1 and TIMP-1 was increased in asthma, demonstrating the potential usefulness of this method of sampling actors related to airway remodeling in asthma.
54. James AL, Maxwell PS, Pearce-Pinto G, et al.: The relationship of reticular basement membrane thickness to airway wall remodeling in asthma. Am J Respir Crit Care Med 2002, 166:1590-1595.
55. Shaw TJ, Wakely SL, Peebles CR, et al.: Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo. Eur Respir J 2004, 23:813-817. This technical study, conducted in sheep, has shown that endobronchial ultrasound is a feasible method of examining the thickness of the bronchial wall in asthma.
56. Armstrong JJ, Leigh MS, Wlaton ID, et al.: In vitro size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography. Opt Express 2003, 11:1817-1826. This proof-of-concept study has shown that measuring optical coherence with a laser beam directed from a rotating prism in a guided catheter can give good surface dimensions of the upper airway in real time. Adaptation for measurement of wall thickness will be possible.
57. Niimi A, Matsumoto H, Amitani R, et al.: Effect of short-term treatment with inhaled corticosteroid on airway wall thickening in asthma. Am J Med 2004, 116:725-731. This study showed for the first time that helical CT could be used to detect partial reductions in the thickness of central airways in patients with asthma after treatment with beclomethasone (800 μg/d) for 12 weeks.
58. James AL, King G: The computed tomographic scan: a new tool to monitor asthma treatment. Am J Med 2004, 116:775-777.
59. Tanaka H, Yamada G, Saikai T, et al.: Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med 2003, 168:1495-1499.
60. Oshita Y, Koga T, Kamimura T, et al.: Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma. Thorax 2003, 58:757-760. This study was able to demonstrate an increase in MMP-9 in the peripheral blood during exacerbations of asthma in 21 patients compared with 21 control subjects with stable asthma. It shows the potential of monitoring markers of airway remodeling in relation to changes in clinical status in asthma.