Asthma: The importance of epithelial mesenchymal communication in pathogenesis: Inflammation and the airway epithelium in asthma

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 12, 2002, Pages 1520-1526

  Davies, D E ^a   Holgate, S T ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Asthma; Eosinophilia; Mesenchyme

Indexed keywords

CORTICOSTEROID;

AIRWAY OBSTRUCTION; ALLERGIC ASTHMA; ANTIINFLAMMATORY ACTIVITY; ASTHMA; ATOPY; BRONCHUS HYPERREACTIVITY; CHRONIC DISEASE; CORTICOSTEROID THERAPY; DISEASE COURSE; ENVIRONMENTAL FACTOR; EOSINOPHILIA; HEREDITY; HUMAN; MESENCHYME; PATHOGENESIS; PATHOPHYSIOLOGY; RESPIRATORY EPITHELIUM; RESPIRATORY TRACT INFLAMMATION; REVIEW; TH2 CELL; TREATMENT FAILURE; BIOLOGICAL MODEL; CELL COMMUNICATION; EPITHELIUM; INFLAMMATION; MESODERM; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ASTHMA; CELL COMMUNICATION; EPITHELIUM; HUMANS; INFLAMMATION; MESODERM; MODELS, BIOLOGICAL;

EID: 0036887572     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(02)00048-1     Document Type: Short Survey

References (17)

1. Lau S., Illi S., Sommerfeld C., Niggemann B., Bergmann R., von Mutius E., Wahn U. Lancet. 356:2000;1392-1397.
2. Leckie M.J., Brinke A.T., Khan J., Diamant Z., O'Connor B., Walls C.M., Mathur A.K., Cowley H.C., Chung K.F., Djukanovic R., Hansel T.T., Holgate S.T., Sterk P.J., Barnes P.J. Lancet. 356:2000;2144-2148.
3. Bryan S.A., Kanabar V., Matti S., Leckie M.J., Khan J., Rolfe L., Renzetti L., Rames A., Bock J.A., Boyce M.J., Hansel T.T., Holgate S.T., O'Connor B.J., Barnes P.J. Lancet. 356:2000;2149-2153.
4. Cokugras H., Akcakaya N., Seckin I., Camcioglu Y., Sarimurat N., Aksoy F. Ultrastructural examination of bronchial biopsy specimens from children with moderate asthma. Thorax. 56:2001;25-29.
5. Pohunek P., Roche W.R., Tarzikova J., Kurdman J., Warner J.O. Eur. Respir. J. 10(Suppl 25):1997;160s.
6. The Childhood Asthma Management Program Research Group, New Engl. J. Med. 343 (2000) 1054-1063.
7. Chung K.F., Barnes P.J. Cytokines in asthma. Thorax. 54:1999;825-857.
8. Puddicombe S.M., Polosa R., Richter A., Krishna M.T., Howarth P.H., Holgate S.T., Davies D.E. The involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J. 14:2000;1362-1374.
9. Lackie P.M., Baker J.E., Günthert U., Holgate S.T. Expression of CD44 isoforms is increased in the airway epithelium of asthmatic subjects. Am. J. Respir. Cell. Mol. Biol. 16:1997;14-22.
10. Holgate S.T., Davies D.E. Epithelial desquamation in asthma. Am. J. Respir. Crit. Care Med. 164:2001;1997.
11. Bucchieri F., Lordan J.L., Richter A., Buchanan D., Djukanovic R., Holgate S.T., Davies D.E. Increased sensitivity of asthmatic bronchial epithelial cells to oxidant-induced injury. Am. J. Respir. Crit. Care Med. 161:2000;A153.
12. Bayram H., Devalia J.L., Khair O.A., Abdelaziz M.M., Sapsford R.J., Sagai M., Davies R.J. Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro. J. Allergy Clin. Immunol. 102:1998;771-782.
13. waf is increased in bronchial epithelium of severe asthmatic subjects. Am. J. Respir. Crit. Care Med. 161:2000;A260.
14. Brewster C.E.P., Howarth P.H., Djukanovic R., Wilson J., Holgate S.T., Roche W.R. Myofibroblasts and sub-epithelial fibrosis in bronchial asthma. Am. Rev. Respir. Cell. Mol. Biol. 3:1990;507-511.
15. Takeyama K., Fahy J.V., Nadel J.A. Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. Am. J. Respir. Crit. Care Med. 163:2001;511-516.
16. Richter A., Puddicombe S.M., Lordan J.L., Bucchieri F., Wilson S.J., Djukanovic R., Dent G., Holgate S.T., Davies D.E. The contribution of interleukin-4 and interleukin-13 to the epithelial-mesenchymal trophic unit in asthma. Am. J. Respir. Cell. Mol. Biol. 25:2001;385-391.
17. N.I. Chaudhary, A. Richter, W.R. Roche, R.M. Powell, L.M. Hamilton, D.E. Davies, S.T. Holgate, The role of autocrine growth factors in proliferation of asthmatic (myo)fibroblasts, Am. J. Respir. Crit. Care Med. (2002), in press.