Genetic manipulation of polyamine catabolism in rodents

Journal of Biochemistry

Volumn 139, Issue 2, 2006, Pages 155-160

  Jänne, Juhani ^a   Alhonen, Leena ^a   Pietilä, Marko ^a   Keinänen, Tuomo A ^a   Uimari, Anne ^a   Hyvönen, Mervi T ^a   Pirinen, Eija ^a   Järvinen, Aki ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Acetyl CoA; Hairlessness; Keratinocyte; Ornithine decarboxylase; Spermidine spermine N1 acetyltransferase; Transgenic mouse and rat

Indexed keywords

ACYLTRANSFERASE; N1 ACETYLSPERMIDINE; POLYAMINE; PUTRESCINE; SPERMIDINE; SPERMIDINE SPERMINE N1 ACETYLTRANSFERASE; SPERMINE; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; BIOSYNTHESIS; CARCINOGENESIS; CATABOLISM; FEMALE INFERTILITY; GENE OVEREXPRESSION; GENETIC MANIPULATION; HAIR LOSS; HOMEOSTASIS; INTESTINE CARCINOGENESIS; KERATINOCYTE; LIPOATROPHY; LIVER REGENERATION; MOUSE; NONHUMAN; PHENOTYPE; PROSTATE CARCINOGENESIS; RAT; REDUCTION; SHORT SURVEY; SKIN CARCINOGENESIS; TRANSGENIC ANIMAL;

ACETYLTRANSFERASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; MICE; NEOPLASMS; POLYAMINES; RATS;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 33645295764     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj035     Document Type: Short Survey

References (42)

1. 14C-spermine in the rat. Acta Physiol. Scand. Suppl. 298, 1-66
2. Hölttä, E. (1977) Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase. Biochemistry 16, 91-100
3. 1-acetyltransferase from livers of rats treated with carbon tetrachloride and its role in the conversion of spermidine into putrescine. J. Biol. Chem. 256, 2454-2458
4. 1-acetyltransferase - the turning point in polyamine metabolism. FASEB J. 7, 653-661
5. 1-acetyltransferase gene in mouse embryonic stem cells. Effects on polyamine homeostasis and sensitivity to polyamine analogues. J. Biol. Chem. 277, 25323-25328
6. Wang, Y., Devereux, W., Woster, P.M., Stewart, T.M., Hacker, A., and Casero, R.A., Jr. (2001) Cloning and characerization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Res. 61, 5370-5373
7. Vujcic, S., Diegelman, P., Bacchi, C.J., Kramer, D.L., and Porter, C.W. (2002) Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem. J. 367, 665-675
8. Sessa, A. and Perin, A. (1994) Diamine oxidase in relation to diamine and polyamine metabolism. Agents Actions 43, 69-77
9. 1-acetyltransferase. J. Biol. Chem. 272, 18746-18751
10. 1-acetyltransferase. Cancer Res. 65, 5390-5398
11. 1-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice. Biochem J. 358, 343-348
12. Alhonen, L., Heikkinen, S., Sinervirta, R., Halmekytö, M., Alakuijala, P., and Jänne, J. (1996) Transgenic mice expressing the human ornithine decarboxylase gene under the control of mouse metallothionein I promoter. Biochem. J. 314, 405-408
13. Alhonen, L., Parkkinen, J.J., Keinänen, T., Sinervirta, R., Herzig, K.H., and Jänne, J. (2000) Activation of polyamine catabolism in transgenic rats induces acute pancreatitis. Proc. Natl. Acad. Sci. USA 97, 8290-8295
14. 1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis. Carcinogenesis 23, 359-364
15. 1- acetyltransferase overexpression. J. Invest. Dermatol. 124, 596-601
16. 1-acetyltransferase. J. Invest. Dermatol. 116, 801-805
17. Soler, A.P., Gilliard, G., Megosh, L.C., and O'Brien, T.G. (1996) Modulation of murine hair follicle function by alterations in ornithine decarboxylase activity. J. Invest. Dermatol. 106, 1108-1113
18. Lu, Y.P., Lou, Y.R., Lin, Y., Shih, W.J., Huang, M.T., Yang, C.S., and Conney, A.H. (2001) Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat. Cancer Res. 61, 5002-5009
19. Kee, K., Foster, B.A., Merali, S., Kramer, D.L., Hensen, M.L., Diegelman, P., Kisiel, N., Vujcic, S., Mazurchuk, R.V., and Porter, C.W. (2004) Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice. J. Biol. Chem. 279, 40076-40083
20. Moitra, J., Mason, M.M., Olive, M., Krylov, D., Gavrilova, O., Marcus-Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., Reitman, M.L., and Vinson, C. (1998) Life without white fat: a transgenic mouse. Genes Dev. 12, 3168-3181
21. 1-acetyltransferase. Diabetologia 45, A83
22. 1-acetyltransferase (SSAT). J. Biol. Chem. 277, 3647-3657
23. Rosenthal, S.M. and Tabor, C.W. (1956) The pharmacology of spermine and spermidine. Distribution and excretion. J. Pharmacol. Exp. Ther. 116, 131-138
24. Räsänen, T.L., Alhonen, L., Sinervirta, R., Keinänen, T., Herzig, K.H., Suppola, S., Khomutov, A.R., Vepsäläinen, J., and Jänne, J. (2002) A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism. J. Biol. Chem. 277, 39867-39872
25. Hyvönen, M.T., Herzig, K-H., Sinervirta, R., Albrech, E., Nordback, I., Sand, J., Keinänen, T.A., Vepsäläinen, J., Grigorenko, N., Khomutov, A.R., Krüger, B., Jänne, J., and Alhonen, L. (2006) Activated polyamine catabolism in pancreatitis: a-Methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality. Am. J. Pathol. 168, 115-122
26. 1-acetyltransferase. Scand. J. Gastroenterol. 40, 120-121
27. Jänne, J. and Raina, A. (1968) Stimulation of spermidine synthesis in the regenerating rat liver: relation to increased ornithine decarboxylase activity. Acta Chem. Scand. 22, 1349-1351
28. Russell, D. and Snyder, S.H. (1968) Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors. Proc. Natl. Acad. Sci. USA 60, 1420-1427
29. Alhonen, L., Räsänen, T.L., Sinervirta, R., Parkkinen, J.J., Korhonen, V.P., Pietilä, M., and Jänne, J. (2002) Polyamines are required for the initiation of rat liver regeneration. Biochem. J. 362, 149-153
30. Park, M.H., Cooper, H.L., and Folk, J.E. (1981) Identification of hypusine, an unusual amino acid, in protein from human lymphocytes and of spermidine as its biosynthetic precursor. Proc. Natl. Acad. Sci. USA 78, 2869-2873
31. Park, M.H., Wolff, E.G., and Folk, J.E. (1993) Is hypusine essential for eukaryotic cell proliferation? Trends Biochem. Sci. 18, 475-479
32. Byers, T.L., Lakanen, J.R., Coward, J.K., and Pegg, A.E. (1994) The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. Biochem. J. 303, 363-368
33. Järvinen, A., Grigorenko, N., Khomutov, A.R., Hyvönen, M.T., Uimari, A., Vepsäläinen, J., Sinervirta, R., Keinänen, T.A., Vujcic, S., Alhonen, L., Porter, C.W., and Jänne, J. (2005) Metabolic stability of alpha-methylated polyamine derivatives and their use as substitutes for the natural polyamines. J. Biol. Chem. 280, 6595-6601
34. Greenberg, N.M., DeMayo, F., Finegold, M.J., Medina, D., Tilley, W.D., Aspinall, J.O., Cunha, G.R., Donjacour, A.A., Matusik, R.J., and Rosen, J.M. (1995) Prostate cancer in a transgenic mouse. Proc. Natl. Acad. Sci. USA 92, 3439-3443
35. Su, L.K., Kinzler, K.W., Vogelstein, B., Preisinger, A.C., Moser, A.R., Luongo, C., Gould, K.A., and Dove, W.F. (1992) Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 256, 668-670
36. Paschen, W. (1992) Polyamine metabolism 7n different pathological states of the brain. Mol. Chem. Neuropathol. 16, 241-271
37. Kauppinen, R.A. and Alhonen, L.I. (1995) Transgenic animals as models in the study of the neurobiological role of polyamines. Progr. Neurobiol. 47, 545-563
38. Najm, I., El-Skaf, G., Tocco, G., Vanderklish, P., Lynch, G., and Baudry, M. (1992) Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain. Dev. Brain Res. 69, 11-21
39. 1-acetyltransferase in transgenic mice protects the animals from kainate-induced toxicity. Eur. J. Neurosci. 12, 540-548
40. 1-acetyltransferase elevates the threshold to pentylenetetrazol- induced seizure activity in transgenic mice. Exp. Neurol. 183, 645-652
41. 1-acetyltransferase overexpression in mice induces hypoactivity and spatial learning impairment. Pharmacol. Biochem. Behav. 78, 35-45
42. Jänne, J., Alhonen, L., Pietilä, M., and Keinänen, T.A. (2004) Genetic approaches to the cellular functions of polyamines in mammals. Eur. J. Biochem. 271, 877-894